What is the chemical structure of N- [2-hydroxy-1- (hydroxymethyl) ethyl] -3- [[2-hydroxy-1- (hydroxymethyl) ethyl] amino] methyl] -5- [[ (2s) -2-hydroxypropanoyl] amino] -2,4,6-triiodo-benzamide?
This is an organic compound, and its chemical structure can be obtained by disassembly according to its name. "N- [2-hydroxy-1- (hydroxymethyl) ethyl] -3- [[2-hydroxy-1- (hydroxymethyl) ethyl] amino] methyl] -5- [ (2s) -2-hydroxypropionyl] amino] -2,4,6-triiodobenzamide".
The main structure of probenzamide, above the benzene ring, has iodine atomic substitution at the 2,4,6 positions. The 3rd position has a nitrogen-containing branch, which starts as a methylene group, and is connected to an amino structure derived from "2-hydroxy-1- (hydroxymethyl) ethyl", that is, the hydroxyl group on this ethyl group is connected to the methylene group, and the other hydroxyl group and hydroxymethyl group are respectively in No. 1 carbon. The 5th position has an amide structure, and the acyl group is (2s) -2-hydroxypropionyl group, that is, the 2-position carbon of the propionyl group is chiral carbon, the configuration is s, and it is connected with a hydroxyl group. The nitrogen atom is connected with the "2-hydroxy-1- (hydroxymethyl) ethyl" structure.
Its structure is complex and contains multi-functional groups. Iodine atoms endow it with special properties. Hydroxy, amino, amide and other functional groups enable the compound to participate in a variety of chemical reactions, which may be of great significance in organic synthesis, medicinal chemistry and other fields.
What are the main uses of N- [2-hydroxy-1- (hydroxymethyl) ethyl] -3- [[2-hydroxy-1- (hydroxymethyl) ethyl] amino] methyl] -5- [[ (2s) -2-hydroxypropanoyl] amino] -2,4,6-triiodo-benzamide?
N - [2-hydroxy-1- (hydroxymethyl) ethyl] -3- [[2-hydroxy-1- (hydroxymethyl) ethyl] amino] methyl] -5- [[ (2s) - 2-hydroxy propionyl] amino] -2,4,6-triiodobenzamide, this is the name of a chemical substance. Looking at its use, in today's medical field, it is mostly used as a contrast agent.
Contrast agents are crucial in medical imaging. In examinations such as X-rays and CT, it can help doctors clearly identify the structure and lesions in the body. The properties of this chemical substance can make specific tissues or organs develop more clearly during imaging, and help doctors accurately diagnose diseases.
Ancient doctors, although they did not have such delicate chemicals, did their best to treat diseases. Today's contrast agents are just like ancient doctors' sharp tools for exploring the source of disease. Over the years, they have become more and more refined. N- [2-hydroxy-1- (hydroxymethyl) ethyl] -3- [[2-hydroxy-1- (hydroxymethyl) ethyl] amino] methyl] -5- [[ (2s) - 2-hydroxy propionyl] amino] -2,4,6-triiodobenzamide as a contrast agent, for doctors to understand the mysteries of the human body, search for the root cause of the disease, providing a key help, in the diagnosis process of modern medicine, plays an indispensable role.
N- [2-hydroxy-1- (hydroxymethyl) ethyl] -3- [[2-hydroxy-1- (hydroxymethyl) ethyl] amino] methyl] -5- [[ (2s) -2-hydroxypropanoyl] amino] -2,4,6-triiodo-benzamide What are the production methods?
To prepare N - [2 - hydroxy - 1 - (hydroxymethyl) ethyl] - 3 - [[2 - hydroxy - 1 - (hydroxymethyl) ethyl] amino] methyl] - 5 - [[ (2s) - 2 - hydroxy propionyl] amino] - 2,4,6 - triiodobenzamide, there are many methods, which are described in detail below.
First, it can be obtained by the gradual introduction of specific groups into the corresponding benzamide derivatives. First take benzamide containing suitable substituents, react with 2-hydroxy-1- (hydroxymethyl) ethylamine with a specific reagent, and connect [2-hydroxy-1- (hydroxymethyl) ethyl] group at the N of benzamide. This step requires mild reaction conditions, fine temperature control and the ratio of reactants to prevent side reactions.
Then, with suitable halogenated reagents, halogen atoms are introduced at specific positions in the benzene ring, and then iodized, and iodine atoms are ingeniously replaced to achieve the structure of 2,4,6-triiodine. This iodization process requires careful selection of iodizing agents and catalysts to optimize the reaction environment and improve the iodization efficiency and selectivity.
As for the introduction of [[[2-hydroxy-1- (hydroxymethyl) ethyl] amino] methyl] and [[ (2s) -2-hydroxypropionyl] amino], the reaction path and conditions need to be adapted according to the reaction characteristics of each step. The former can be skillfully integrated by nucleophilic substitution and other reactions with reagents containing corresponding active groups; the latter needs to be introduced by (2s) -2-hydroxypropionic acid as the starting material, after appropriate activation, and the target intermediate.
In addition, there are other methods. The main body of the benzene ring can be constructed first, and then the side chain groups can be spliced on it in sequence. The iodine-containing benzene ring skeleton is first prepared, and then different substituted side chains are introduced one by one. Each step of the reaction needs to fine-tune the reaction parameters according to the characteristics of the group to ensure that the reaction proceeds in the expected direction to obtain a high-purity N - [2-hydroxy-1- (hydroxymethyl) ethyl] -3- [[2-hydroxy-1- (hydroxymethyl) ethyl] amino] methyl] -5- [ (2s) - 2-hydroxypropionyl] amino] -2,4,6-triiodobenzamide product.
How safe is N- [2-hydroxy-1- (hydroxymethyl) ethyl] -3- [[2-hydroxy-1- (hydroxymethyl) ethyl] amino] methyl] -5- [[ (2s) -2-hydroxypropanoyl] amino] -2,4,6-triiodo-benzamide?
N - [2-hydroxy-1 - (hydroxymethyl) ethyl] - 3 - [[2-hydroxy-1 - (hydroxymethyl) ethyl] amino] methyl] - 5 - [[ (2s) - 2 -hydroxy propionyl] amino] - 2,4,6 -triiodobenzamide, this is a chemical substance. Its safety is related to many aspects, and it will be discussed in detail now.
Looking at this chemical substance, its structure is complex and contains many types of functional groups. However, in the study of safety, the first focus should be on its toxicological properties. If this substance enters the body, or through oral administration, inhalation, or skin contact. When taken orally, the gastrointestinal tract may be the first place of contact, if it is irritating, or causes gastrointestinal discomfort, such as abdominal pain, vomiting, etc. In the case of inhalation, the respiratory tract bears the brunt, or causes coughing, asthma, and even lung damage. Skin contact If this substance is corrosive, it can cause skin redness, swelling, and ulceration.
On its chemical activity, it contains hydroxyl groups, amino groups, etc., or chemically reacts with biomolecules in the body. For example, amino groups can react with acids in living organisms, or interfere with normal biochemical metabolic pathways. Although hydroxyl groups are commonly found in many bioactive molecules, their chemical environment or unique reactions in this substance affect the normal function of cells.
In terms of environmental safety, if this substance is released into the environment, it may affect water ecology, soil ecology, etc. It may affect the survival and reproduction of aquatic organisms in water bodies, or change the chemical properties of water bodies. In soil, or affect soil microbial communities, and then affect soil fertility and plant growth.
In summary, the safety of N- [2-hydroxy-1- (hydroxymethyl) ethyl] -3- [[2-hydroxy-1- (hydroxymethyl) ethyl] amino] methyl] -5- [[ (2s) -2-hydroxypropionyl] amino] -2,4,6-triiodobenzamide requires rigorous scientific research, considering its toxicology, chemical activity and environmental effects and other factors, in order to obtain an accurate determination.
N- [2-hydroxy-1- (hydroxymethyl) ethyl] -3- [[2-hydroxy-1- (hydroxymethyl) ethyl] amino] methyl] -5- [[ (2s) -2-hydroxypropanoyl] amino] -2,4,6-triiodo-benzamide What is the market outlook?
N - [2-hydroxy-1- (hydroxymethyl) ethyl] - 3 - [[2-hydroxy-1- (hydroxymethyl) ethyl] amino] methyl] - 5 - [ (2S) - 2-hydroxy propionyl] amino] - 2,4,6-triiodobenzamide, a rather complex organic compound. Looking at its market prospects, it is like a slowly spreading picture, which is quite impressive.
In the field of medical imaging, this compound can be called a shining star. Because it is rich in iodine, it can shine brightly in X-ray, CT and other imaging examinations. The characteristics of iodine make it have excellent X-ray absorption capacity, so it can significantly improve the clarity and contrast of imaging. For example, when CT scans of internal organs of the human body, such as liver and kidneys, the introduction of this compound as a contrast agent is like opening a pair of fluoroscopic eyes for the doctor, which can clearly see the shape, structure and presence of diseases of the organs. Abnormal conditions such as tumors and stones are not hidden.
Furthermore, from the perspective of market demand, with the intensification of the global population aging process, the incidence of various diseases is also on the rise. At the same time, medical diagnostic technology is constantly improving, and the demand for high-quality contrast agents is growing like thirsty soil, eager for rain. This compound, with its excellent performance, undoubtedly occupies an important position in the contrast agent market. In order to improve the accuracy of diagnosis, many medical institutions continue to increase their demand for it, promoting the steady expansion of the market scale.
However, it is also necessary to be soberly aware that the road to the market is not smooth. The technical threshold for developing this compound is quite high, and the requirements for the production process are almost strict. It is necessary to precisely control all links in order to ensure the stability of product quality. And the market competition is also quite fierce, and many pharmaceutical companies have entered the field of contrast agent research and development, hoping to get a share. In order to gain a foothold in this market, it is not only necessary to continuously optimize the production process, reduce costs, but also to continuously innovate and improve product performance in order to ride the wave of the market and stand firm.