What is the chemical structure of N- [ (2r) -2,3-dihydroxypropoxy] -3,4-difluoro-2- [ (2-fluoro-4-iodophenyl) amino] benzamide?

This is an organic compound, and its name is N- [ (2r) -2,3-dihydroxypropoxy] -3,4-difluoro-2-[ (2-fluoro-4-iodophenyl) amino] benzamide. To know its chemical structure, it can be analyzed step by step according to the naming rules.

"N - [ (2r) -2,3-dihydroxypropoxy]", this part reveals that there is a propoxy group, a hydroxyl group at the 2 and 3 positions, and the configuration is 2r. " 3,4-Difluoro-2- [ (2-fluoro-4-iodophenyl) amino] benzamide "indicates that on the benzene ring of benzamide, there are fluorine atoms at the 3rd and 4th positions, and (2-fluoro-4-iodophenyl) amino groups at the 2nd position.

With benzamide as the core structure, the 2 positions on one side of the benzene ring are connected by the amino group to another benzene ring. The 2 positions of the benzene ring have fluorine atoms and the 4 positions have iodine atoms; the 3 and 4 positions on the other side of the benzene ring have fluorine atoms. The [ (2r) -2,3-dihydroxypropoxy] attached to the N atom is a propoxy group with one hydroxyl group at the 2nd and 3rd positions, showing a 2r configuration. This structural feature makes it have unique chemical properties and reactivity, which may be of important value in the fields of organic synthesis and medicinal chemistry.

What are the main physical properties of N- [ (2r) -2,3-dihydroxypropoxy] -3,4-difluoro-2- [ (2-fluoro-4-iodophenyl) amino] benzamide?

N- [ (2r) -2,3-dihydroxypropoxy] -3,4-difluoro-2-[ (2-fluoro-4-iodophenyl) amino] benzamide, which is an organic compound. Its physical properties are quite important, and it is related to many properties and applications of this compound.

First of all, its appearance is often in the state of white to quasi-white crystalline powder, which is delicate and uniform, like the first snow in winter, and has a pure morphology. This appearance feature is quite valuable for the identification and preliminary judgment of the state of the compound.

Second, the melting point is about 150-155 ° C. Just like ice and snow meet the warm sun, the temperature reaches this point, and the material state gradually changes, from solid to liquid. Melting point is an inherent property of the compound, which is indispensable in purity detection and quality control. It is like a weight and measure to accurately define its quality level.

Furthermore, the solubility shows good solubility in common organic solvents such as dichloromethane, N, N-dimethylformamide, just like fish get water and blend seamlessly; however, the solubility in water is poor, like oil droplets entering water, which is difficult to miscible. This difference in solubility guides the experimenter to choose the appropriate solvent and process path in the process of compound extraction, separation and preparation.

The complex theory density is about 1.7-1.8 g/cm ³, which indicates that its unit volume mass is heavier. If it is placed next to other lightweight substances of the same volume, it can intuitively feel its heavy texture. This physical property may have certain reference significance in material selection and product design considerations.

Finally, looking at its stability, under conventional environmental conditions, the compound is relatively stable, just like a stable old man, calm; but in the case of strong oxidizing agents, strong acids and alkalis and other extreme chemical environments, the structure may change, like a fragile boat encountering violent winds and waves, making it difficult to maintain its original form. Knowing this stability characteristic, when storing, transporting, and using the compound, it is possible to use it as a compass, properly selecting conditions to ensure that its properties are intact.

What are the common uses of N- [ (2r) -2,3-dihydroxypropoxy] -3,4-difluoro-2- [ (2-fluoro-4-iodophenyl) amino] benzamide?

N- [ (2r) -2,3-dihydroxypropoxy] -3,4-difluoro-2-[ (2-fluoro-4-iodophenyl) amino] benzamide is a complex organic compound. Its common uses are mostly found in the field of medicinal chemistry.

It is often used as a key intermediate in the process of drug development. Taking the creation of new antibacterial and antiviral drugs as an example, this compound can precisely fit with specific biological targets due to its unique chemical structure. With its dihydroxypropoxy, difluoro and iodophenylamino groups, it can effectively intervene in the physiological process of pathogens. If it interacts with pathogen proteins or nucleic acids, it hinders its normal metabolism and reproduction, and achieves antibacterial and antiviral effects.

In pharmaceutical chemistry research, it is also the cornerstone of optimizing the molecular structure of drugs. Researchers fine-tune the physical and chemical properties and biological activities of compounds by modifying their substituents. Or change the position of fluorine atoms and adjust the substituents on the benzene ring to improve the affinity of drugs to targets and improve pharmacokinetic properties, such as enhancing drug solubility and stability, optimizing absorption, distribution, metabolism and excretion characteristics, so that drugs have better efficacy and fewer side effects.

And because of its complex structure and diverse activities, it is also a research hotspot in the field of organic synthetic chemistry. Chemists focus on developing efficient and green synthesis methods to improve their efficiency and yield, reduce production costs and environmental impact. Explore novel reaction pathways and catalytic systems, and optimize reaction conditions to achieve large-scale preparation and meet drug development and production needs.

What are the preparation methods of N- [ (2r) -2,3-dihydroxypropoxy] -3,4-difluoro-2- [ (2-fluoro-4-iodophenyl) amino] benzamide?

The preparation method of N - [ (2R) -2,3-dihydroxypropoxy] -3,4-difluoro-2- [ (2-fluoro-4-iodophenyl) amino] benzamide, although the ancient book "Tiangong Kaiwu" does not contain this material, it can be deduced according to the ancient synthesis idea.

To prepare this product, you can first take 3,4-difluorobenzoic acid as the base, and condensate it with 2-fluoro-4-iodoaniline with an appropriate reagent to obtain 3,4-difluoro-2-[ (2-fluoro-4-iodophenyl) amino] benzoic acid. This step requires mild reaction conditions to prevent the removal of fluorine and iodine atoms.

Then, the obtained acid is converted into an active ester or acyl chloride, and then reacted with (2R) -2,3-dihydroxypropanol. This process requires attention to the configuration maintenance of the alcohol, which can be carried out in a suitable organic solvent under weak base catalysis, such as dichloromethane, tetrahydrofuran, etc., so that the reaction can occur smoothly, and finally N - [ (2R) -2,3-dihydroxypropoxy] -3,4-difluoro-2 - [ (2-fluoro-4-iodophenyl) amino] benzamide.

Or another way is to first protect the amino group with 2-fluoro-4-iodoaniline with an appropriate protective group, and then react with 3,4-difluorobenzoic acid derivatives. After forming an amide bond, the protective group is removed, and then connected with (2R) -2,3-dihydroxypropanol. This route can reduce side reactions and improve product purity. When

is prepared, the temperature, time and proportion of reactants in each step need to be finely adjusted, and the product needs to be purified by recrystallization, column chromatography, etc., to obtain pure N - [ (2R) -2,3 -dihydroxypropoxy] -3,4 -difluoro-2 - [ (2 -fluoro-4 -iodophenyl) amino] benzamide.

What are the precautions for N- [ (2r) -2,3-dihydroxypropoxy] -3,4-difluoro-2- [ (2-fluoro-4-iodophenyl) amino] benzamide during use?

N - [ (2r) -2,3-dihydroxypropoxy] -3,4-difluoro-2-[ (2-fluoro-4-iodophenyl) amino] benzamide There are many things to pay attention to when using this product.

Bearing the brunt is the most important thing for safety. This chemical may be potentially dangerous, such as the risk of irritation to the skin, eyes or respiratory tract. Therefore, when using it, be sure to have protective equipment, such as gloves, goggles and masks, to avoid direct contact and inhalation, so as not to harm the body.

Furthermore, accurate weighing and operation are essential. Due to its unique chemical properties, the dosage is slightly poor, or the reaction result is a thousand miles away. When weighing, when using a precise weighing instrument, the operation should also follow strict procedures, and there should be no omissions, in order to ensure the accuracy and stability of the experiment or production.

Repeat, storage should not be underestimated. It needs to be placed in a dry, cool and well-ventilated place, away from fire sources and oxidants. Due to its chemical structure, improper storage environment or qualitative change will damage its quality and utility.

In addition, during use, the reaction conditions need to be strictly controlled. Factors such as temperature and pH can affect its chemical behavior. Only by maintaining suitable reaction conditions can the desired reaction effect be achieved.

And pay attention to the disposal of waste. After use, the residue should not be discarded at will. It should be properly disposed of in accordance with relevant environmental regulations to avoid polluting the environment.

In short, the use of this N - [ (2r) -2,3-dihydroxypropoxy] -3,4-difluoro-2 - [ (2-fluoro-4-iodophenyl) amino] benzamide requires careful attention to safety, operation, storage, reaction conditions and waste disposal.