What is the chemical structure of N- {[ (2r) -2,3 - dihydroxypropyl] oxy} -3,4 - difluoro - 2 - [ (2 - fluoro - 4 - iodophenyl) amino] benzamide

This is the name of an organic compound. To know its chemical structure, it is necessary to disassemble and analyze it according to the rules of organic chemistry. "N - {[ (2r) -2,3-dihydroxypropyl] oxy} -3,4-difluoro-2 - [ (2-fluoro-4-iodophenyl) amino] benzamide", where "N -" indicates that the substituent is attached to the nitrogen atom. "[ (2r) -2,3-dihydroxypropyl] oxy", which can be regarded as a complex substituent, with propyl as the group, dihydroxy is added at the 2 and 3 positions, and the configuration is (2r), and then connected to the oxygen group. " 3,4-Difluoro-2- [ (2-fluoro-4-iodophenyl) amino] benzamide ", then benzamide is used as the parent nucleus, and fluorine atoms are introduced into the 3 and 4 positions of the benzene ring, and there is a substituent composed of 2-fluoro-4-iodophenyl and amino groups at the 2 positions. In this way, the parts are connected in sequence, which can outline the chemical structure of the compound. The approximate structure is the parent body of benzamide, with fluorine atoms and fluoroiodophenyl amino substitutions at specific positions in the benzene ring, and nitrogen atoms are connected with two-hydroxy propyloxy substituents of a specific configuration.

N- {[ (2r) -2,3 - dihydroxypropyl] oxy} -3,4 - difluoro - 2 - [ (2 - fluoro - 4 - iodophenyl) amino] What is the main use of benzamide

N- {[ (2r) -2,3 -dihydroxypropyl] oxy} -3,4 -difluoro-2- [ (2 -fluoro-4 -iodophenyl) amino] benzamide This substance is mostly studied and used in the field of medicinal chemistry in this world. Its main use is in the process of pharmaceutical research and development.

Because of the way of medicine, it is related to the health of living beings, and it is necessary to find effective agents to treat various diseases. The structure of this compound is unique, and its characteristics may have unique manifestations in pharmacological action. Or it can be used as a lead compound, and medical researchers can use its structure to modify and modify it chemically, hoping to obtain new drugs with better curative effect and less side effects.

Or in the exploration of the therapeutic mechanism of diseases, this compound can provide researchers with clues. Looking at its action path in vivo and observing its interaction with biological macromolecules, research assistants understand the deep mechanism of disease occurrence and development, thus paving the way for the creation of new therapies and the production of new drugs.

Furthermore, in the process of drug screening, it may be an important tool. By leveraging modern high-throughput screening technology and using it as a sample, active substances that are compatible with it can be quickly screened out, accelerating the process of new drug research and development, providing patients with early recovery and hope.

What is the safety of N- {[ (2r) -2,3 - dihydroxypropyl] oxy} -3,4 - difluoro - 2 - [ (2 - fluoro - 4 - iodophenyl) amino] benzamide

N- {[ (2r) -2, 3 - dihydroxypropyl] oxy} -3, 4 - difluoro - 2 - [ (2 - fluoro - 4 - iodophenyl) amino] benzamide is a chemical compound. The safety of this chemical compound needs to be investigated in many ways.

In terms of toxicological properties, this chemical compound is integrated into biological matter, or interacts with multi-biological macromolecules such as proteins and nucleic acids. The distribution of fluorine atoms and iodine atoms in it or the sub-cloud of molecular matter in it changes its chemical activity and biological activity. However, it may lead to cytotoxicity, and the normal generation, proliferation and differentiation of the cell cause adverse effects, or even apoptosis. In the environment, if a high amount of this substance is given, or the substance shows toxicities such as weight decline, organ pathological modification, etc.

It is safe for the environment. If this substance is released into the environment, it may be rapidly degraded by microorganisms in the natural environment due to its phase, or it may be retained in the environment such as water and soil, or it may be enriched by organisms. It does not affect the survival and reproduction of aquatic organisms and soil organisms, but also affects the health of food, high-quality organisms and even human health.

In terms of safety in use, if the operator does not take proper preventive measures during industrial or commercial operations, it may cause irritation due to skin contact or inhalation of powder, steam, or skin, respiratory tract, etc. And in the process of storage, it is necessary to consider its transformation and characterization to avoid the interaction of incompatible materials, so as to prevent the degradation of life-threatening products. The safety of N- {[ (2r) -2,3 -dihydroxypropyl] oxy} -3,4 -difluoro-2- [ (2 -fluoro-4 -iodophenyl) amino] benzamide requires comprehensive and in-depth research, and its toxicological, environmental and use characteristics can be fully clarified before it can be used reasonably and safely.

N- {[ (2r) -2,3 - dihydroxypropyl] oxy} -3,4 - difluoro - 2 - [ (2 - fluoro - 4 - iodophenyl) amino] benzamide What are the synthesis methods

N- {[ (2r) -2,3-dihydroxypropyl] oxy} -3,4-difluoro-2-[ (2-fluoro-4-iodophenyl) amino] benzamide is a rather complex organic compound. The synthesis method is as follows:

The selection of starting materials is extremely critical. Aromatic halides containing fluorine and iodine, such as 2-fluoro-4-iodoaniline, can be selected first, which is the basis for the construction of key aryl structures in the molecule. In addition, raw materials that can provide dihydroxypropoxy moiety, such as properly protected 2,3-dihydroxypropanol derivatives, need to be selected.

The first step may be nucleophilic substitution reaction. React 2-fluoro-4-iodoaniline with a benzoic acid derivative containing an appropriate leaving group to form an amide bond. This reaction needs to be carried out in the presence of a suitable base and solvent, which can promote the formation of nucleophiles, and the solvent should be able to dissolve the reactants and stabilize the reaction intermediates. For example, potassium carbonate can be selected as a base, and N, N-dimethylformamide (DMF) can be selected as a solvent. Under moderate heating conditions, the reaction can be smoothly advanced to form 2 - [ (2-fluoro-4-iodophenyl) amino] benzoic acid derivatives.

Then, the 2,3-dihydroxypropyl alcohol derivative is properly treated to transform one of its hydroxyl groups into a good leaving group, such as methanesulfonate or p-toluenesulfonate. Subsequently, this derivative is reacted with the benzoic acid derivative obtained in the previous step under the action of a base to achieve nucleophilic substitution, and the [ (2r) -2,3-dihydroxypropyl] oxy part is introduced. This step also requires fine regulation of the reaction conditions. The strength of the base, the reaction temperature and time all have a significant impact on the reaction yield and selectivity.

During the entire synthesis process, the reaction products in each step need to be separated and purified. Common methods include column chromatography and recrystallization to ensure the purity and quality of the final product. And a variety of analytical methods, such as nuclear magnetic resonance (NMR), mass spectrometry (MS), etc. are needed to accurately identify the structure and purity of the product. In this way, N- {[ (2r) -2,3 -dihydroxypropyl] oxy} -3,4 -difluoro-2 - [ (2 -fluoro-4 -iodophenyl) amino] benzamide can be successfully synthesized.

N- {[ (2r) -2,3 - dihydroxypropyl] oxy} -3,4 - difluoro - 2 - [ (2 - fluoro - 4 - iodophenyl) amino] benzamide market prospects

Nowadays, there is N- {[ (2r) -2,3-dihydroxypropyl] oxy} -3,4-difluoro-2-[ (2-fluoro-4-iodophenyl) amino] benzamide. What is the prospect of this product in the market?

Looking at this compound, its structure is complex and unique, or it has a specific biological activity. In the field of medicine, the fine difference in structure is often related to the huge difference in pharmacological efficacy. Such benzamide derivatives containing fluorine, iodine and other halogen atoms may have high affinity for specific biological targets and can be used to develop new drugs. For example, in the development of anti-tumor drugs, fluorinated compounds often improve the metabolic stability and fat solubility of the drug due to the special properties of fluorine atoms, and enhance their penetration and inhibitory effect on tumor cells.

However, looking at its market prospects, it also faces many challenges. Synthesizing such compounds with complex structures is difficult and costly, which is a constraint to mass production. And the road to new drug development is long, and it needs to go through multiple rounds of rigorous trials. From cell experiments, animal experiments to human clinical trials, there is a risk of failure. If the research and development is successful, it still needs to face market competition. Although its unique structure may bring novel therapeutic effects, similar drugs may already occupy part of the market share.

If it can solve the synthesis problem, reduce costs and increase efficiency, and demonstrate excellent efficacy and safety in clinical studies, N- {[ (2r) -2,3-dihydroxypropyl] oxy} -3,4-difluoro-2- [ (2-fluoro-4-iodophenyl) amino] benzamide may emerge in the pharmaceutical market and gain a share.