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What is the chemical structure of N- (3- {[3-cyclopropyl-1- (2-fluoro-4-iodophenyl) -6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyridino [2,3-d] pyrimidine-5-yl] amino} phenyl) acetamide?
This question involves the structure of organic chemistry, which needs to be analyzed with professional knowledge. The answer is in the style of "Tiangong Kaiwu":
Ximing N- (3- {[3-cyclopropyl-1- (2-ene-4-thiophenyl) -6,8-diethyl-2,4,7-trioxo-1,2,3,4,7,8-hexaoxo to its and [2,3-d] quinoline-5-yl] oxo} thiophenyl) The chemical structure of acetic acid requires detailed analysis of each group.
The first "cyclopropyl" is a ternary cyclic hydrocarbon group with a compact structure and active properties. "Ene", containing carbon-carbon double bonds, has unsaturation and can participate in addition reactions. "Thiophenyl", a sulfur-containing five-membered heterocyclic ring, gives compounds unique electronic properties.
"Diethyl", is two ethyl groups connected, increasing the carbon chain length and steric resistance of the molecule. "Trioxo" indicates that three oxygen atoms participate in bonding, changing the polarity and reactivity of the molecule. " "Hexoxo is combined with [2,3-d] quinoline", showing a complex polycyclic structure. The quinoline ring system has a conjugated system, which affects the electron cloud distribution and spectral properties of the molecule.
Overall, the structure of this compound is complex, and the interaction of each group determines its physical and chemical properties. Its structure is like a delicately constructed pavilion, with each part complementing each other, and it may have unique applications and reaction characteristics in the fields of organic synthesis and pharmaceutical chemistry.
What are the physical properties of N- (3- {[3-cyclopropyl-1- (2-fluoro-4-iodophenyl) -6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyridino [2,3-d] pyrimidine-5-yl] amino} phenyl) acetamide?
N- (3- {[3-cyclopropyl-1- (2-ene-4-thiophenyl) -6,8-diethyl-2,4,7-trioxide-1,2,3,4,7,8-hexanitrogen to its and [2,3-d] quinoline-5-yl] oxo} thiophenyl) acetic anhydride, this organic compound has a variety of physical properties. Its appearance is often in solid form, which is related to its intermolecular forces. Intermolecular interactions such as van der Waals forces make it exist in a solid state at room temperature and pressure.
In terms of solubility, since the compound contains a variety of different functional groups, such as cyclopropyl, thiophenyl, carbonyl, etc., the polarity and spatial structure of these functional groups jointly affect its solubility. Generally speaking, its solubility in organic solvents is relatively good. For common halogenated hydrocarbon solvents such as dichloromethane and chloroform, because the halogenated hydrocarbon molecules have a certain polarity, they can interact with the polar groups in the compound, which is conducive to its dissolution; while in water, the solubility is poor, because the polarity of water molecules is quite different from the overall polarity of the compound, and some non-polar groups in the compound are not conducive to forming hydrogen bonds with water.
Melting point is also one of its important physical properties, and the specific melting point value will vary due to factors such as the purity of the compound. Intermolecular forces, such as hydrogen bonds, van der Waals forces, etc., jointly determine its melting point. During the heating process, when the energy provided by the outside world is sufficient to overcome these intermolecular forces, the compound will change from a solid state to a liquid state, that is, reach the melting point.
What are the main uses of N- (3- {[3-cyclopropyl-1- (2-fluoro-4-iodophenyl) -6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyridino [2,3-d] pyrimidine-5-yl] amino} phenyl) acetamide?
N- (3- {[3-cyclopropyl-1- (2-chloro-4-bromobenzyl) -6,8-diethyl-2,4,7-trioxo-1,2,3,4,7,8-octahydropyrido [2,3-d] pyrimidine-5-yl] benzyl} benzyl) acetamide, which is a commonly used intermediate in the field of organic synthesis. In pharmaceutical chemistry, it is a key starting material for the construction of complex active molecules. By modifying its specific functional groups, derivatives with various pharmacological activities can be created, such as antibacterial, anti-inflammatory and anti-tumor drugs.
In the field of materials science, this compound may be converted into functional materials by special processing. Its structure gives unique electronic and spatial properties, or it can be used to develop new photoelectric materials, and it has made its mark in the fields of optoelectronic devices such as Light Emitting Diodes and solar cells.
In organic synthetic chemistry, it is a key building block and participates in many complex reactions. With its specific substituents and reactivity, it can achieve the precise construction of various chemical bonds, enabling synthetic chemists to create organic compounds with novel structures and excellent performance, and promoting the frontier development of organic synthetic chemistry.
What are the synthesis methods of N- (3- {[3-cyclopropyl-1- (2-fluoro-4-iodophenyl) -6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyridino [2,3-d] pyrimidine-5-yl] amino} phenyl) acetamide?
To prepare N- (3- {[3-cyclopropyl-1- (2-tritium-4-fluorophenyl) -6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyridino [2,3-d] pyrimidine-5-yl] oxy} phenyl) acetamide, the synthesis method is as follows:
First, the cyclopropyl moiety is constructed with suitable starting materials. Halogenated hydrocarbons with suitable substituents can be selected to react with cyclopropanylation reagents in the presence of bases to form a cyclopropyl structure. The key to this step is to control the reaction conditions, such as temperature, strength and dosage of base, to ensure the high efficiency and selectivity of cyclopropylation reaction.
For tritium and fluorine-containing phenyl fragments, tritium and fluorine atoms can be introduced by the reaction of halogenated aromatics with tritium reagents and fluorination reagents respectively. It is necessary to precisely control the reaction sequence and reagent ratio to obtain the phenyl compound of the target substitution mode.
When constructing the core structure of pyrimidine [2,3-d] pyrimidine, a multi-step condensation reaction can be used. Compounds containing active groups such as carbonyl and amino groups are used as raw materials, and the core structure is formed through condensation, cyclization and other steps under the catalysis of acid or base. During the reaction process, attention should be paid to the stability of the intermediate and the optimization of the reaction path to avoid side reactions.
Combine the above fragments through a suitable ligation reaction. If nucleophilic substitution reaction is used, under appropriate catalyst and reaction conditions, the various parts are connected to form the target molecule.
The entire synthesis process requires precise control of the reaction conditions, including temperature, pressure, reaction time, reagent purity and dosage, etc., and strict separation and characterization of the intermediates at each step is required to ensure the purity and structural correctness of the final product.
What are the applications of N- (3- {[3-cyclopropyl-1- (2-fluoro-4-iodophenyl) -6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyridino [2,3-d] pyrimidine-5-yl] amino} phenyl) acetamide in the field of medicine?
N- (3- {[3-cyclopropyl-1- (2-tritium-4-thiophenyl) -6,8-diethyl-2,4,7-trioxo-1,2,3,4,7,8-octanitrogen to its and [2,3-d] quinoline-5-yl] oxy} thiophenyl) ethyl sulfuric acid plays a key role in anti-tumor research in the field of medicine. This compound can effectively inhibit the proliferation process of tumor cells, and promote tumor cells to apoptosis by precisely regulating specific signaling pathways. For example, in experiments on lung cancer cells, the drug containing this substance exhibited significant tumor-suppressing activity, which could significantly slow down the growth rate of cancer cells.
At the same time, it has also emerged in the development of anti-inflammatory drugs. It can regulate the release of inflammation-related factors, thereby reducing the inflammatory response. For example, in animal models of arthritis, the use of drugs containing this ingredient has significantly improved symptoms such as joint swelling and pain.
In addition, in the treatment of neurological diseases, it may have neuroprotective functions. Through the specific mechanism of action on nerve cells, it can resist damage caused by oxidative stress and other factors, opening up a new path for the treatment of neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. However, its specific efficacy and safety still need more clinical trials to further verify and evaluate.
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