What is the chemical structure of N- {3- [3-cyclopropyl-1- (2-fluoro-4-iodophenyl) -6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyridino [2,3-d] pyrimidine-5-ylamino] phenyl} acetamide

This is a question related to the naming of organic compounds. The full name of this compound is N - {3 - [3 - cyclopropyl - 1 - (2 - chloro - 4 - bromophenyl) -6,8 - diethyl - 2,4,7 - trioxo - 1,2,3,4,7,8 - hexahydroquinolino [2,3 - d] pyrimidine - 5 - yloxy] phenyl} acetamide.

According to the naming rules of organic chemistry, this compound is based on acetamide as the parent, and the nitrogen atom is connected to a complex substituent. The core of this substituent is a quinoline-pyrimidine structure with cyclopropyl, chlorobromophenyl, diethyl and other substituents on it, and there are multiple oxygen groups. The 3-position is connected to the oxygen-containing phenyl group. In this way, the chemical structure of this compound is constructed. In its structure, the nitrogen atom of acetamide is connected to a specific substituted phenyl group to form a whole structure. The positions of the quinoline-pyrimidine ring system are modified by different groups, giving the compound unique chemical properties. The analysis of this chemical structure requires familiarity with the characteristics and nomenclature of various groups in organic chemistry to accurately grasp.

What is the main use of N- {3- [3-cyclopropyl-1- (2-fluoro-4-iodophenyl) -6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyridino [2,3-d] pyrimidine-5-ylamino] phenyl} acetamide

N- {3- [3-cyclopropyl-1- (2-deuterium-4-chlorobenzyl) -6,8-diethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydroquinoxolino [2,3-d] pyrimidine-5-ylamino] benzyl} acetamide, which is a class of organic compounds with important uses in the field of pharmaceutical chemistry. In the field of drug development, its role is crucial. Due to its specific chemical structure, it can precisely bind to specific targets in organisms, just like a delicate key to match specific locks, thus exhibiting unique physiological activities.

or can adjust specific biological signaling pathways, just like regulating the traffic rules of complex transportation networks, so that cell activities can return to normal track. In the process of anti-tumor drug research and development, it may inhibit the proliferation of tumor cells, just like stepping on the brakes for the crazy growth of cells, blocking their out-of-control division, and then providing a possible way to overcome the cancer problem; in the exploration of drugs for neurological diseases, it may regulate the transmission of neurotransmitters, just like accurately adjusting the communication line signal, improving the abnormal function of the nervous system, and bringing hope for recovery to patients.

This compound has great potential in many fields of drug research and development, so it attracts many researchers to devote themselves to research, hoping to explore in depth, tap its more potential, and create new brilliance for human health.

What are the synthesis methods of N- {3- [3-cyclopropyl-1- (2-fluoro-4-iodophenyl) -6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyridino [2,3-d] pyrimidine-5-ylamino] phenyl} acetamide

To prepare N - {3 - [3 - cyclopropyl - 1 - (2 - tritium - 4 - chlorobenzyl) - 6,8 - diethyl - 2,4,7 - trioxo - 1,2,3,4,7,8 - hexaazabicyclo [2,3 - d] octane - 5 - oxybenzyl] benzyl} acetamide, the method is as follows:

Take an appropriate amount of 3 - cyclopropyl - 1 - (2 - tritium - 4 - chlorobenzyl) - 6,8 - diethyl- 2,4,7-trioxo-1,2,3,4,7,8-hexaazabicyclo [2,3-d] octane-5-ol, in a clean reactor, dissolved in a suitable organic solvent, such as dichloromethane, etc., stir well. In addition, prepare benzyl halides containing appropriate substituents, such as benzyl bromide or benzyl chloride, slowly drop them into the reactor, and add an appropriate amount of acid binding agent, such as potassium carbonate or triethylamine, to maintain the alkaline environment of the reaction system. At room temperature or moderate heating conditions, stir the reaction number. Monitor the reaction progress by thin layer chromatography, and stop the reaction after the reaction of the raw materials is complete. The reaction solution was poured into an appropriate amount of water, extracted several times with an organic solvent, and the organic phases were combined. After drying with anhydrous sodium sulfate, the solvent was removed by distillation under reduced pressure to obtain a solvent containing 3- [3-cyclopropyl-1- (2-tritium-4-chlorobenzyl) -6,8-diethyl-2,4,7-trioxo-1,2,3,4,7,8-hexaazabicyclo [2,3-d] octane-5-oxybenzyl] benzyl intermediate.

Then take this intermediate, dissolve it in a suitable solvent, such as tetrahydrofuran, add an acetaminating agent, such as acetyl chloride or acetic anhydride, or react with acetic acid in the presence of a condensing agent such as dicyclohexylcarbodiimide (DCC) and a catalyst 4-dimethylaminopyridine (DMAP), and stir the reaction at an appropriate temperature for a certain period of time. The reaction was also monitored by thin-layer chromatography. After the reaction was completed, the post-treatment was as before, and the crude product was obtained through extraction, drying, and distillation. The crude product is purified by column chromatography or recrystallization to obtain pure N - {3 - [3 - cyclopropyl - 1 - (2 - tritium - 4 - chlorobenzyl) -6,8 - diethyl - 2,4,7 - trioxo - 1,2,3,4,7,8 - hexaazabicyclo [2,3 - d] octane - 5 - oxybenzyl] benzyl} acetamide.

What is the safety of N- {3- [3-cyclopropyl-1- (2-fluoro-4-iodophenyl) -6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyridino [2,3-d] pyrimidine-5-ylamino] phenyl} acetamide?

This is related to the safety of chemical compounds. N - {3 - [3 - propyl - 1 - (2 - cyanogen - 4 - chlorobenzyl) -6,8 - diethyl - 2,4,7 - trioxo - 1,2,3,4,7,8 - hexapyrimidine [2,3 - d] pyrimidine - 5 - ylamino] benzyl} acetamide, the safety of this compound needs to be analyzed in many ways.

First, it contains propyl, cyano, chlorobenzyl and other groups. Propyl has special anti-reactive activity, or some chemical reactions, or modifying chemical properties because of its properties. Cyanyl is a absorber group, which is highly toxic, or skin absorption, respiratory inhalation, etc., dry organisms have normal biochemical reactions, such as inhibiting the activity of certain enzymes in cellular respiration. The presence of chlorine atoms in chlorobenzyl, or the lipid and qualitative properties of the affected substances, etc., and the benzyl group can also be substituted.

In addition, its use is recommended. If used in the field, it can be dispersed in the air, causing biological contact in the surrounding environment, or exhaustion in soil and water, harming non-target organisms. If used in the synthesis of benzyl, it will remain in the finished product, or cause adverse reactions to patients.

It also tests its physical properties, such as solubility. If it is easily soluble in water, it is easy to disperse in the water environment and increase pollution. If it has high solubility, it is easy to put it in the large area and breathe into the organism.

Therefore, N - {3 - [3 - propyl - 1 - (2 - cyanogen - 4 - chlorobenzyl) -6,8 - diethyl - 2,4,7 - trioxo - 1,2,3,4,7,8 - hexapyrimidine [2,3 - d] pyrimidine - 5 - ylamino] benzyl} The safety of acetamide needs to be studied and cannot be ignored.

How competitive is N- {3- [3-cyclopropyl-1- (2-fluoro-4-iodophenyl) -6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyridino [2,3-d] pyrimidine-5-ylamino] phenyl} acetamide in the market?

Alas! This is about N - {3 - [3 - propyl - 1 - (2 - cyanogen - 4 - chlorophenyl) - 6,8 - diethyl - 2,4,7 - trioxo - 1,2,3,4,7,8 - hexapyridine [2,3 - d] pyrimidine - 5 - ylamino] phenyl} acetamide is also available in the market.

This compound, which is formed by the combination of poly-groups. Propyl, cyano, chlorophenyl, diethyl, trioxo, and hexapyridine pyrimidine are all groups, each of which has its own characteristics. Propyl can affect the molecular space, such as molecular molecules. Cyanyl has properties, and it can multiply, react, and interact with molecules. Chlorophenyl can reduce the density of fat-soluble compounds.

In terms of market effectiveness, the characteristics of this compound may determine its use. If it has high biological activity, such as good biological activity, it is effective in specific diseases, and has small toxic and side effects, it must have a significant impact on the market. However, if its synthesis is high, the cost is high, or the qualitative quality is poor, it must limit its promotion.

And the same product, if there is already a compound of similar quality and performance on the market, then N - {3 - [3 - propyl - 1 - (2 - cyano- 4 - chlorophenyl) -6,8 - diethyl - 2,4,7 - trioxo - 1,2,3,4,7,8 - hexapyridine [2,3 - d] pyrimidine - 5 - ylamino] phenyl} acetamide has a special property, so it can be produced in the system.