What is the chemical structure of N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodo-4-quinazolinamine
This is the name of an organic compound, and its chemical structure is complex, which can be gradually analyzed according to the naming rules. "N - {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodine-4-quinazolinamide", with quinazolinamide as the parent structure, its 4-position is connected with a phenyl group containing a specific substituent, 3-chloro, 4- [ (3-fluorobenzyl) oxy] modified this phenyl group; 6-position is connected with an iodine atom. Quinazolinamide has a bilicyclic structure, contains nitrogen atoms, and is basic, which is of great significance in organic synthesis and drug development. 3-Chlorine is a hydrogen atom at the 3-position of the benzene ring substituted by a chlorine atom; (3-fluorobenzyl) oxygen, which is a benzyl oxygen connected to the 4-position of the benzene ring, and the 3-position of the benzyl ring is substituted by a fluorine atom. In this way, the structure of this compound is clear, and the positions and types of each substituent are determined. In the fields of chemical research and medicine, the structure can be studied according to its properties, activities and reactions, which lays the foundation for the creation of new drugs and the exploration of new synthesis
What is the main use of N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodo-4-quinazolinamine
N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodine-4-quinazolinamine, this is an organic compound. Looking at its structure and characteristics, it can be seen that its use is mainly in the field of pharmaceutical research and development.
In the exploration path of modern medicine, many organic compounds are the cornerstones of the creation of new drugs. This compound has a unique structure, in which halogen atoms such as chlorine, fluorine, and iodine, as well as specific structural fragments such as quinazolinamide, give it potential biological activity. Or it can interact with specific targets in organisms, such as binding with certain proteins and enzymes, and then show the efficacy of treating diseases.
For example, in the long road of anti-tumor drug development, many compounds containing quinazoline structures have emerged. Quinazoline compounds can specifically act on targets such as tyrosine kinase overexpressed in tumor cells, blocking the proliferation and metastasis signaling pathways of tumor cells, so as to inhibit tumor growth. The iodine atoms in this compound can adjust the electron cloud distribution of the molecule and enhance its binding force with the target; the introduction of fluorine atoms can often improve the metabolic stability and fat solubility of the compound, which is conducive to its passage through the biofilm and better drug efficacy.
Or in the exploration of antibacterial drugs, the structural properties of the compound may make it inhibitory to some bacteria. Bacterial cell wall synthesis, protein synthesis and other key physiological processes may be blocked due to the action of this compound, eventually resulting in bacterial growth inhibition and even death.
Although the exact results of its experimental research are not known, in terms of the potential contained in its structural characteristics, it is very likely to become a key "puzzle" in the search for new therapeutic drugs in the field of medicine, providing new ideas and opportunities for solving various diseases.
What are the synthesis methods of N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodo-4-quinazolinamine
The method of synthesizing N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodine-4-quinazolinamide often follows the following methods.
First, 4-chloro-6-iodoquinazoline is used as the starting material. First, 4-chloro-6-iodoquinazoline and 3-chloro-4-hydroxybenzaldehyde are mixed in a suitable organic solvent, catalyzed by a base, such as potassium carbonate, etc., through nucleophilic substitution reaction to obtain the corresponding etheride. The etheride is then reacted with a suitable amine source, such as an amine containing 3-fluorobenzyl group, under suitable conditions. The amine group attacks the chlorine atom on the quinazoline ring and undergoes nucleophilic substitution, and then synthesizes the target product.
Second, 3-chloro-4- [ (3-fluorobenzyl) oxy] aniline is used as the starting material. First, it is reacted with a suitable acylating agent to obtain an amide intermediate. This intermediate is then cyclized, or a suitable cyclizing agent, such as polyphosphoric acid, is used to promote the cyclization of the molecule to form a quinazoline ring structure. After that, at a specific position on the ring, iodine atoms are introduced through an iodine substitution reaction, and the target product can be obtained by using an iodine source and appropriate catalysts, such as potassium iodide and hydrogen peroxide systems.
Third, 6-iodine-4-quinazolinone is used as the starting material. It is first halogenated to introduce chlorine atoms, and halogenated reagents such as phosphorus oxychloride are commonly used. The obtained haloquinazolinone is then reacted with 3-chloro-4- [ (3-fluorobenzyl) oxy] aniline, and through the nucleophilic substitution process, the target N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6 -iodine-4 -quinazolinamide is generated.
All synthesis methods have their own advantages and disadvantages. According to the actual situation, consider the availability of raw materials, the difficulty of reaction conditions, and the high or low yield. Choose the appropriate one and use it.
What are the physical properties of N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodo-4-quinazolinamine
N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodine-4-quinazolinamine, this is an organic compound. Looking at its structure, it is composed of quinazolinamine core structure, connected with specific substituted phenyl groups. Halogen atoms such as chlorine, fluorine, iodine and benzyloxy groups are distributed in it, and this structure gives it unique physical properties.
First, its physical state is described, under normal temperature and pressure, or it is a solid powder. Due to the interaction of van der Waals force and hydrogen bonds between the molecules, the molecules are arranged in an orderly manner and take on the shape of a solid state. In terms of melting and boiling point, the melting point and boiling point may be relatively high due to the large number of atoms in the molecule, the complex structure, and the strong intermolecular forces. To make the molecule overcome the intermolecular forces and realize the phase state transition requires more energy.
In terms of solubility, due to its halogen atom, aromatic ring and other hydrophobic groups, the solubility in water is poor. Water is a polar solvent, and the polarity of this compound is relatively weak. According to the principle of "similar compatibility", it is difficult to dissolve in water. However, in organic solvents such as dichloromethane, chloroform, N, N-dimethylformamide (DMF), it may have some solubility. Organic solvents such as dichloromethane and chloroform have moderate polarity and good solubility, and can form intermolecular forces with compound molecules to promote dissolution; DMF is a strong polar organic solvent, which can interact with groups containing nitrogen and oxygen atoms in compounds to form hydrogen bonds, etc., to enhance solubility.
Its density may be greater than that of water. Due to the large relative atomic weight of iodine atoms in the molecule, the overall molecular weight increases, and the molecular structure is compact, resulting in a large unit volume mass.
In addition, the compound contains a conjugated aromatic ring structure, or has certain optical properties. Under the irradiation of specific wavelengths of light, it may be absorbed and emitted. It can be used in the research of optical materials and other fields. Due to its complex structure and a variety of active groups, it may exhibit unique chemical activities in chemical reactions, providing a research foundation for organic synthesis, drug development, and other fields.
N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodo-4-quinazolinamine
Today there is a product called N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodine-4-quinazolinamide. The prospect of this product in the market is related to many aspects.
In the field of Guanfu Medicine, such compounds often have unique pharmacological activities. Because of their delicate structure, they may be combined with specific biological targets to play a therapeutic effect. For example, in the development of anti-tumor drugs, many quinazoline-containing structures have emerged, which may inhibit the proliferation of tumor cells and induce their apoptosis. This N - {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodine-4-quinazolinamide, if it can show outstanding performance in pharmacological research, will be favored by the pharmaceutical industry, and the market prospect is quite promising.
As for the field of pesticides, there are also opportunities. Today's demand for high-efficiency, low-toxicity and environmentally friendly pesticides is increasing. The structural characteristics of the compound, or its insecticidal and bactericidal effects, if properly developed, it is expected to become an alternative for new pesticides and open up a new market.
However, its market prospect is not smooth. The difficulty of synthesis is the primary consideration. If the synthesis steps are complicated and expensive, large-scale production and marketing activities will be hindered. Furthermore, safety assessment is also crucial. Whether it is used in medicine or pesticides, it is necessary to ensure that it does not pose significant harm to the human body and the environment. Only through rigorous safety tests can one be eligible for market entry.
In conclusion, N - {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodine-4-quinazolinamide has both opportunities and challenges in the market prospect. If we can overcome the problems of synthesis and safety, we will be able to shine in the fields of medicine, pesticides, and gain a place in the market.