N-{3-Chloro-4-[(3-Fluorobenzyl)Oxy]Phenyl}-6-Iodoquinazolin-4-Amine

The chemical structure of this compound is actually a delicate and complex structure in the field of organic chemistry. Its name is N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-ioquinazoline-4-amine.
The core structure of quinazoline, which is a nitrogen-containing heterocycle, is formed by the merger of quinoline rings with a nitrogen atom. The iodine atom is introduced at the 6th position to change its chemical activity and electron cloud distribution. The 4-position connecting amine group, the amine group is nucleophilic and plays a key role in many reactions, affecting the reactivity and biological activity of the compound.
Looking at the phenyl group connected to quinazoline, there is a chlorine atom at the 3rd position, and an oxygen atom at the 4th position is bridged with 3-fluorobenzyl. The chlorine atom has electron absorption, which affects the electron cloud density of the phenyl group, and the fluorine atom in the 3-fluorobenzyl group also plays a role in the overall properties of the molecule. The presence of benzyl groups makes the molecule have a certain lipid solubility, which affects its absorption and distribution in living organisms.
In this way, each atom and the group interact and cooperate to build this complex and unique chemical structure, which may have potential application value in the fields of medicinal chemistry and other fields.

N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodoquinazoline-4-amine is a kind of organic compound. Its physical properties are related to the morphology, melting point, boiling point, solubility and density of this substance, and are quite important in chemical research and application.
Looking at its morphology, it is mostly solid under normal circumstances. Due to the force between molecules, the molecules attract each other tightly, causing it to condense into a solid state. Its melting point also has a specific value. The melting point is also the temperature at which the substance changes from solid to liquid. The determination of the melting point of the compound requires precise experimental means and can be obtained by thermal analysis and other methods. This melting point information is of great significance in the identification, separation and purification of the compound. If the purity is high, the melting point is sensitive and close to the theoretical value; if it contains impurities, the melting point is reduced and the melting range is widened.
The boiling point is also one of the key physical properties. The boiling point is the temperature at which a substance changes from liquid to gaseous state under a specific pressure. However, due to the relatively complex structure of the compound, it contains a variety of functional groups, or its boiling point is quite high. The exact boiling point value needs to be determined experimentally, which has a profound impact on the distillation separation, gas chromatography analysis and other operations of the compound.
Solubility is related to the solubility of the compound in various solvents. Its molecular structure contains halogen atoms such as chlorine, fluorine, and iodine, as well as hydrophobic groups such as benzene rings and quinazoline rings, and amino groups that can form hydrogen bonds, so its solubility varies in different solvents. In polar organic solvents such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), or because hydrogen bonds and other intermolecular forces can be formed between molecules and solvents, the solubility is good; in non-polar solvents such as n-hexane, the solubility is poor. This solubility characteristic has a great impact on the choice of solvents for drug development and organic synthesis reactions.
The density of the compound is also the mass of the substance per unit volume. The density of the compound also depends on experimental determination, and its value is related to the molecular structure and the way of molecular packing. Density data has important uses in the storage, transportation and chemical reaction measurement of substances.
In summary, the physical properties of N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6 -ioquinazoline-4 -amine are very useful in many fields of chemistry. Accurate determination and in-depth understanding of its properties are the foundation for rational application of this substance.

N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodoquinazoline-4-amine, this is an organic compound. Looking at its use, in the field of medicinal chemistry, it is often a key intermediate for the development of new drugs.
Taking the creation of anti-tumor drugs as an example, many quinazoline compounds have shown significant inhibitory effects on the proliferation of tumor cells. The quinazoline parent nucleus in the structure of this compound, together with iodine atoms, chlorine atoms and fluorobenzyl-containing substituents, may endow it with unique biological activities. By modifying and modifying these groups, it may be possible to optimize their affinity and selectivity to specific tumor cell targets, thus achieving better therapeutic effects.
Furthermore, in the process of medicinal chemistry research, it can also be used as a lead compound, and researchers can find new drug candidates with stronger activity and lower toxicity through structural modification and activity evaluation. In the long journey of drug development, such compounds are like cornerstones, paving the way for the creation of new drugs in the future, and helping the medical field make great strides towards conquering difficult diseases.

To prepare N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodoquinazoline-4-amine, the following method can be followed.
First, 3-chloro-4-hydroxyaniline needs to be prepared. With a suitable halogenated aniline as the starting material, the hydroxyl group is introduced into the appropriate position through a substitution reaction under specific conditions. Then, 3-fluorobenzyl halide is reacted with 3-chloro-4-hydroxyaniline, which is a nucleophilic substitution reaction, and 3-chloro-4- [ (3-fluorobenzyl) oxy] aniline can be obtained.
Another 6-iodoquinazoline-4-halide is prepared. Using quinazoline as the starting material, iodine atoms are introduced at the 6th position through halogenation reaction, and substitutable halogen atoms are left at the 4th position.
Finally, 3-chloro-4- [ (3-fluorobenzyl) oxy] aniline is reacted with 6-iodoquinazoline-4-halide, and both are in the presence of suitable bases and solvents. In the presence of nucleophilic substitution, the amine group replaces the 4-position halogen atom, and the final target product is N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodoquinazoline-4-amine. During the reaction process, the progress of the reaction should be monitored by thin-layer chromatography, and the product should be purified by column chromatography or recrystallization to obtain a pure product.

N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodoquinazoline-4-amine, according to its name, this substance is known as the product of organic synthesis, and may have potential in the field of pharmaceutical research and development. Geiinquinazoline compounds are often found in a variety of drug molecular structures, and can interact with many targets in organisms due to their unique chemical properties.
When it comes to market prospects, with the rapid advancement of medical technology, there is a hunger for new and efficient drugs. The special substituents of this compound may endow it with excellent biological activity and selectivity, and there is broad room for development in the creation of anti-cancer, anti-inflammatory and other disease therapeutic drugs.
Looking back at the past, quinazoline derivatives have made remarkable achievements in the research and development of anti-cancer drugs, and some have been approved for marketing, bringing good news to patients. Today, the birth of N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodoquinazoline-4-amine, if its biological activity is deeply explored and verified, will attract the attention of pharmaceutical companies and scientific research institutions.
However, its market expansion is not smooth. The road to new drug research and development is long and full of thorns. It requires rigorous pharmacological and toxicological experiments, and clinical trials also require a lot of time, manpower and financial resources. And the competition among the same kind is fierce. Many scientific research teams and pharmaceutical companies are engaged in the development of new drugs. To stand out, they need to show unique advantages.
In summary, N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-ioquinazoline-4-amine has a bright future, but it also faces many challenges. Only through the unremitting research and exploration of scientific researchers can it be expected to shine in the pharmaceutical market and contribute to the cause of human health.