N 4 Chloro 5 Iodo 7h Pyrrolo 2 3 D Pyrimidin 2 Yl 2 2 Dimethylpropionamide
Iodobenzene

N 4 Chloro 5 Iodo 7h Pyrrolo 2 3 D Pyrimidin 2 Yl 2 2 Dimethylpropionamide

Fengxi Chemical

Specifications

HS Code

973593

Chemical Formula C12H14ClIN4O
Molecular Weight 392.62
Appearance Solid (predicted)
Melting Point Unknown
Boiling Point Unknown
Solubility In Water Low (predicted)
Logp 3.2 (predicted)
Pka Unknown
Density Unknown
Vapor Pressure Low (predicted)
Chemical Formula C12H14ClIN4O
Molar Mass 392.62 g/mol
Chemical Formula C12H14ClIN4O
Molecular Weight 392.62
Chemical Name N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropionamide
Molecular Formula C11H12ClIN4O
Molecular Weight 380.599 g/mol
Packing & Storage
Packing 100 - gram vial of N-(4 - chloro - 5 - iodo - 7H - pyrrolo[2,3 - d]pyrimidin - 2 - yl)-2,2 - dimethylpropionamide.
Storage Store N-(4 - chloro - 5 - iodo - 7H - pyrrolo[2,3 - d]pyrimidin - 2 - yl)-2,2 - dimethylpropionamide in a cool, dry place away from direct sunlight. Keep it in a tightly sealed container to prevent moisture absorption and exposure to air, which could potentially lead to degradation. Store away from incompatible substances to avoid chemical reactions.
Shipping The chemical "N-(4 - chloro - 5 - iodo - 7h - pyrrolo[2,3 - d]pyrimidin - 2 - yl)-2,2 - dimethylpropionamide" is shipped in well - sealed containers, compliant with chemical transport regulations, ensuring safety during transit.
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N-(4-chloro-5-iodo-7h-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropionamide N-(4-chloro-5-iodo-7h-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropionamide N-(4-chloro-5-iodo-7h-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropionamide
General Information
Frequently Asked Questions
What is the chemical structure of N- (4-chloro-5-iodo-7h-pyrrolo [2,3-d] pyrimidin-2-yl) -2,2-dimethylpropionamide
This is the name of the organic compound, which is composed of many parts. "N- (4-chloro-5-iodine-7H-pyrrolido [2,3-d] pyrimidine-2-yl) -2,2-dimethylpropionamide", according to this name, its chemical structure can be depicted.
First look at "2,2-dimethylpropionamide", this is the basic structure of propionamide, propionamide is propionyl group (CH < unk > CH < unk > CO -) connected to amino group (-NH < unk >), 2,2-dimethyl indicates that there are two methyl groups (-CH < unk >) substituted on the 2-position carbon of propionyl group, and this part of the structure is (CH < unk >) < unk > C - CONH -.
Then look at "4-chloro-5-iodine-7H-pyrrolido [2,3-d] pyrimidine-2-yl", pyrrolido [2,3-d] pyrimidine is a fused heterocyclic structure, which is formed by fusing pyrrole ring with pyrimidine ring. 4-Chloro, 5-iodine indicate that there is a chlorine atom (-Cl) at the 4th position and an iodine atom (-I) at the 5th position at a specific position in the fused ring. 2-group means that the 2-position of the fused ring is connected to other parts, and this part of the structure is pyrrolido [2,3-d] pyrimidine-2-group containing a specific substituent.
Finally, "N -" means that the above two parts are connected in such a way that pyrrolido [2,3-d] pyrimidine-2-group is connected to the propionamide nitrogen atom (N). In summary, the chemical structure of this compound is: (CH < unk >) < unk > C - CONH - linked to pyrrolido [2,3 - d] pyrimidine-2 - group containing 4 - chloro - 5 - iodine substitution.
What are the main uses of N- (4-chloro-5-iodo-7h-pyrrolo [2,3-d] pyrimidin-2-yl) -2,2-dimethylpropionamide
N- (4-chloro-5-iodine-7H-pyrrolido [2,3-d] pyrimidine-2-yl) -2,2-dimethylpropionamide, this compound has a wide range of uses in the field of medicinal chemistry. It plays a key role in the development of anti-cancer drugs and can hinder the proliferation and metastasis of tumor cells by inhibiting specific kinases. In the creation of molecular targeting drugs, it is like a precise "key" that can specifically bind to targets on tumor cells to achieve high-efficiency and low-toxicity therapeutic effects.
Furthermore, it has also emerged in the exploration of immunomodulatory drugs. It may be able to modulate the body's immune response, enhance the immune system's ability to recognize and eliminate pathogens and tumor cells, and open up a new path for the treatment of immune-related diseases.
In the field of antiviral drug research, this compound is also involved. It may be able to inhibit the replication process of viruses, providing a new alternative for antiviral therapy. By acting on specific enzymes or proteins required for virus replication, it interferes with the reproduction of viruses in the host, providing a powerful weapon against viral infection.
In addition, in the construction of new drug delivery systems, it can act as a carrier or modifier of active ingredients. With the ingenious design and modification of its structure, the stability, solubility and targeting of the drug can be improved, so that the drug can reach the site of action more accurately, enhance the curative effect and reduce the side effects. In this way, it can bring more possibilities and innovations to drug development.
What is the synthesis method of N- (4-chloro-5-iodo-7h-pyrrolo [2,3-d] pyrimidin-2-yl) -2,2-dimethylpropionamide
To prepare N- (4-chloro-5-iodine-7H-pyrrolido [2,3-d] pyrimidine-2-yl) -2,2-dimethylpropionamide, the following ancient method can be used.
First, the raw materials need to be prepared, 4-chloro-5-iodine-7H-pyrrolido [2,3-d] pyrimidine-2-amine and 2,2-dimethylpropionyl chloride, which are the key materials.
In a clean reaction bottle, inject an appropriate amount of organic solvents, such as dichloromethane or tetrahydrofuran, to create a suitable reaction environment. Subsequently, 4-chloro-5-iodine-7H-pyrrolido [2,3-d] pyrimidine-2-amine is slowly added to it, and it is stirred to disperse uniformly.
Then, at a low temperature and under continuous stirring, add 2,2-dimethylpropionyl chloride dropwise. This process needs to be done with caution. Due to the active reaction, it can be added too quickly or cause the reaction to get out of control. After the dropwise addition is completed, the reaction temperature is gradually raised to room temperature and stirred continuously for several times to allow the reaction to proceed fully.
After the reaction is completed, the completion of the reaction can be confirmed by thin-layer chromatography or other suitable monitoring means. When the reaction is complete, pour the reaction mixture into an appropriate amount of water to stop the reaction. Subsequently, the organic phase is extracted with an organic solvent such as ethyl acetate to collect the organic phase.
The organic phase is dried with a desiccant such as anhydrous sodium sulfate to remove moisture. After drying is completed, the desiccant is filtered off, and then the organic solvent is steamed by reduced pressure distillation to obtain the crude product.
Finally, the crude product is refined by column chromatography or recrystallization, and a suitable eluent or solvent is selected to obtain pure N- (4-chloro-5-iodine-7H-pyrrolido [2,3-d] pyrimidine-2-yl) -2,2-dimethylpropionamide. In this way, the synthesis of this compound is completed according to the ancient method.
What are the physical properties of N- (4-chloro-5-iodo-7h-pyrrolo [2,3-d] pyrimidin-2-yl) -2,2-dimethylpropionamide
N- (4-chloro-5-iodine-7H-pyrrolido [2,3-d] pyrimidine-2-yl) -2,2-dimethylpropionamide, which is an organic compound. Looking at its structure, it is formed by connecting the pyrrolido-pyrimidine ring containing chlorine and iodine to the dimethylpropionamide group.
In terms of its physical properties, it is in a solid state at room temperature. Because of its intermolecular force, it has a certain melting point, but the exact value needs to be determined accurately by experiment. The solubility of this substance may not be good in water, due to the large proportion of hydrocarbons in the molecule and the limited polar groups, which makes the interaction between it and water molecules weak. And in organic solvents, such as dichloromethane, N, N-dimethylformamide, it may have good solubility, because these organic solvents and the compound molecules can form interactions such as van der Waals forces to help it disperse and dissolve.
Furthermore, the color state of this substance may be white to light yellow powder or crystal. Due to the absence of too much conjugate system in the structure, it absorbs visible light and develops color. However, halogen atoms and amide groups may have a slight impact on its color. Its density also needs to be determined experimentally, but it is roughly equivalent to that of common organic compounds. Due to its relative molecular weight and molecular accumulation, it will have a corresponding effect on the density.
What is the safety of N- (4-chloro-5-iodo-7h-pyrrolo [2,3-d] pyrimidin-2-yl) -2, 2-dimethylpropionamide
N- (4-chloro-5-iodine-7H-pyrrolido [2,3-d] pyrimidine-2-yl) -2,2-dimethylpropionamide, which is an organic compound. However, there are not many detailed ancient records on its safety, so I will analyze it in the style of ancient Chinese.
The safety of this compound first involves its chemical structure. The substitution of 4-chloro and 5-iodine on the pyrrolido-pyrimidine ring may cause it to have certain chemical activity. The presence of chlorine and iodine atoms may affect the stability and reactivity of the compound. From the perspective of toxicity, the introduction of halogen atoms may increase their potential toxicity to organisms. When chlorine and iodine are metabolized in the body, or interact with biological macromolecules such as proteins and nucleic acids, they interfere with normal physiological functions.
If its safety to the environment is considered, its degradability should be considered. Organic halides are usually difficult to degrade and persist in the environment. After they enter environmental media such as water and soil, or are transmitted and enriched through the food chain, they endanger the balance of the ecosystem.
Furthermore, the route of exposure is also related to safety. If exposed through skin, the compound may penetrate the skin barrier and enter the blood circulation, damaging the internal organs. Inhaled through the respiratory tract, it may be deposited in the lungs, causing lung inflammation, respiratory dysfunction and other diseases. Accidentally ingested, ingested, in the digestive system, or react with digestive juices, damage gastrointestinal mucosa, affect digestion and absorption function.
Although this substance is not detailed in ancient books, according to the current knowledge of chemistry and toxicology, N- (4-chloro-5-iodine-7H-pyrrolido [2,3-d] pyrimidine-2-yl) -2,2-dimethylpropionamide is latent risk in biological and environmental levels. When using and disposing, it should be treated with caution to prevent the growth of hazards.