What is the chemical structure of N- [5- (3-iodoimidazo [1,2-a] pyridin-6-yl) -2-methoxy-3-pyridinyl] cyclopropanesulfonamide

This is an organic compound with a rather complex chemical structure. Looking at its name "N- [5- (3-iodoimidazolo [1,2-a] pyridine-6-yl) -2-methoxy-3-pyridyl] cyclopropanesulfonamide", its structure can be analyzed according to the following ideas.

"Cyclopropanesulfonamide" is the core skeleton of the compound. Cyclopropane is a cyclic structure composed of three carbon atoms, with a sulfonamide group attached to it. Sulfonamide is formed by linking a sulfonyl group (-SO 2O -) with an amino group (-NH 2O).

Looking at the "N- [5- (3-iodoimidazolo [1,2-a] pyridine-6-yl) -2-methoxy-3-pyridyl]" part again, this is the substituent attached to the nitrogen atom of cyclopropane sulfonamide. Among them, pyridine is a nitrogen-containing hexamembered heterocycle, and "2-methoxy-3-pyridyl" indicates that there is a methoxy (-OCH) substitution at position 2 of the pyridine ring, and position 3 is connected to the nitrogen atom of the cyclopropane sulfonamide.

And "5- (3-iodoimidazolo [1,2-a] pyridine-6-yl) " is the substituent of the pyridine ring at position 5. Imidazolo [1,2-a] pyridine is a fused heterocycle formed by fusing the imidazole ring with the pyridine ring, with iodine atom substitution at position 3, and position 6 is connected to the pyridine ring at position 5. In this way, the chemical structure of this compound is composed of a cyclopropane sulfonamide core, which is connected with complex pyridine and heterocyclic substituents, and each part is connected by chemical bonds to form a unique spatial structure and chemical properties.

What are the physical properties of N- [5- (3-iodoimidazo [1,2-a] pyridin-6-yl) -2-methoxy-3-pyridinyl] cyclopropanesulfonamide

N - [5- (3-iodoimidazolo [1,2-a] pyridine-6-yl) -2-methoxy-3-pyridyl] cyclopropanesulfonamide, which is an organic compound. According to its physical properties, it may be solid at room temperature. As for its color, it may be in a white to pale yellow powder form, which is characteristic of many compounds of this type of structure. Its melting point may vary depending on the intermolecular forces and the stability of the structure, but it may undergo phase transition within a specific temperature range.

In terms of solubility, the performance of this compound in organic solvents is quite critical. Due to the fact that its molecular structure contains polar sulfonamide and methoxy groups, as well as non-polar pyridine and imidazolo-pyridine parts, it may exhibit good solubility in polar organic solvents, such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), due to the formation of hydrogen bonds or dipole-dipole interactions between polar groups and polar solvents. However, in non-polar organic solvents, such as n-hexane and toluene, the solubility may be poor, because the non-polar parts are difficult to effectively miscible with non-polar solvents.

Furthermore, the density of the compound is also related to its molecular accumulation and atomic weight. Although the exact value needs to be determined experimentally and accurately, the density range can be inferred from the structure and similar compounds. And because its molecular structure contains iodine atoms, iodine atoms have a large atomic weight, or the density of the compound is relatively high.

As for volatility, due to the existence of various forces between molecules, and the relatively large molecular weight, volatility or low, it is not easy to disperse into the air at room temperature and pressure.

What is the synthesis method of N- [5- (3-iodoimidazo [1,2-a] pyridin-6-yl) -2-methoxy-3-pyridinyl] cyclopropanesulfonamide

The synthesis of N- [5- (3-iodoimidazolo [1,2-a] pyridine-6-yl) -2-methoxy-3-pyridyl] cyclopropane sulfonamide is a key research in the field of organic synthetic chemistry. The synthesis usually follows the following steps:

The first step requires the preparation of key intermediates. Generally speaking, a suitable pyridine derivative is used as the starting material, and a halogen atom is introduced at a specific position in the pyridine ring by halogenation reaction. The subsequent reaction activity of this halogen atom is extremely high, which can be used as an important check point for subsequent reactions. For example, under suitable reaction conditions, a specific pyridine derivative is reacted with a halogenated reagent, and the reaction temperature, time, and ratio of the reactants are carefully controlled, so that the halogen atom precisely replaces the hydrogen atom at the target position to form a halogenated pyridine derivative.

Next step, the structure of imidazolo [1,2-a] pyridine is constructed. The halogenated pyridine derivative is reacted with a nitrogen-containing heterocyclic compound in the presence of a base and a catalyst in a suitable organic solvent. The base can adjust the pH of the reaction system, and the catalyst can speed up the reaction rate and improve the reaction efficiency. Through this kind of reaction, the two-molecule compound is cleverly connected, and the structure of imidazolo [1,2-a] pyridine is gradually constructed to form an intermediate containing imidazolo [1,2-a] pyridine. This process requires close attention to the control of reaction conditions to ensure that the reaction proceeds in the desired direction and improves the yield of the target product.

The third step is to introduce a cyclopropane sulfonamide group. The intermediate obtained in the second step is reacted with cyclopropane sulfonyl chloride or other suitable cyclopropane sulfonamide reagents in the presence of a base. The base action is to neutralize the acid generated by the reaction and promote the reaction forward. After this reaction, the cyclopropane sulfonamide group was successfully introduced into the molecule, and the final target product was N - [5 - (3-iodoimidazolo [1,2-a] pyridine-6-yl) -2 -methoxy - 3 -pyridyl] cyclopropane sulfonamide.

However, in the synthesis process, the fine regulation of each step of the reaction conditions is extremely important. Factors such as temperature, pH, ratio of reactants and reaction time all have a significant impact on the reaction yield and product purity. After each step of the reaction, it is often necessary to use separation and purification methods such as column chromatography and recrystallization to obtain high-purity intermediates and target products to ensure the success of the synthesis path and the quality of the products.

What are the applications of N- [5- (3-iodoimidazo [1,2-a] pyridin-6-yl) -2-methoxy-3-pyridinyl] cyclopropanesulfonamide in medicine?

N- [5- (3-iodoimidazolo [1,2-a] pyridine-6-yl) -2-methoxy-3-pyridyl] cyclopropanesulfonamide, this compound has unique uses in the field of medicine.

Looking at its structure, it is connected by cyclopropanesulfonamide with specific pyridine derivatives, and the structure is exquisite, giving it unique pharmacological activity. It can be used as a targeted drug in the treatment of diseases. Take cancer as an example. The etiology of cancer is complex, and abnormal cell proliferation is difficult to control. With its unique structure, this compound may be able to precisely bind to specific targets of cancer cells, blocking the proliferation signaling pathway of cancer cells, such as cutting off the "supply line" of cancer cell growth, curbing its crazy growth, and opening up new paths for cancer treatment.

In the field of neurological diseases, such as Alzheimer's disease, the signal transmission disorder between brain nerve cells. The compound may regulate the release of neurotransmitters and stabilize the signaling between nerve cells, just like repairing the chaotic "communication network", alleviating the disease and helping patients return to normal life.

In inflammation-related diseases, when inflammation occurs, the body overflows with inflammatory mediators. This compound may inhibit the synthesis and release of inflammatory mediators, such as lowering "sedatives" for out-of-control "inflammatory storms", reducing inflammation and relieving pain for many inflammatory patients.

It can be seen that N - [5- (3-iodoimidazolo [1,2-a] pyridine-6-yl) -2 -methoxy-3-pyridine] cyclopropanesulfonamide has great potential in the field of medicine, and is expected to bring new hope for the treatment of various diseases and become the gospel of patient recovery.

N- [5- (3-iodoimidazo [1,2-a] pyridin-6-yl) -2-methoxy-3-pyridinyl] cyclopropanesulfonamide

N- [5- (3-iodoimidazolo [1,2-a] pyridine-6-yl) -2-methoxy-3-pyridyl] cyclopropanesulfonamide, this compound may have promising prospects in the field of drug research and development. Looking at today's pharmaceutical market, there is a hunger for new kinds of specific drugs. This compound may emerge due to its unique structure and potential biological activity.

In its structure, iodine atoms are cleverly connected to imidazolo-pyridine, pyridine and other parts, and cyclopropanesulfonamide is also unique. This unique structure, or endowing it with good pharmacological properties, may be able to act precisely on the therapeutic targets of many diseases.

In terms of the development of anti-cancer drugs, the occurrence and development of many cancers are related to the abnormality of specific targets. The structure of this compound may make it fit some key targets, blocking the proliferation and metastasis pathways of cancer cells, and bringing opportunities for the innovation of anti-cancer drugs. And in the research of drugs for neurological diseases, it may be helpful for the treatment of difficult diseases such as Alzheimer's disease and Parkinson's disease because it can regulate the transmission of neurotransmitters.

There are also challenges to really gallop the market. The optimization of the synthetic process is the top priority, and it is necessary to find efficient and green methods to improve the yield and reduce the cost. The evaluation of safety and efficacy should not be underestimated, and rigorous clinical trials must be conducted to ensure that it is harmless to the human body and the curative effect is accurate. However, with time and overcoming all kinds of difficulties, it may be able to shine like a pearl in the pharmaceutical market and bring good news to patients.