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What is the chemical structure of N-acetyl-3,5-diiodotyrosine?
N-acetyl-3,5-diiodotyrosine is a fascinating chemical compound. This is one of the iodine-containing tyrosine derivatives.
Its core is the backbone of tyrosine. Tyrosine is a phenylalanine-derived β-group. On this base, the 3-position 5-position atom is replaced by an iodine atom. The introduction of this iodine atom greatly improves its chemical properties and physiological activities. The iodine atom has a large atom semi-atomic properties, a molecular properties, and a space-type, and it interacts with other molecules.
Furthermore, the N-position is connected to an ethyl group. Acetyl - COCH, formed from carbonyl methyl. The addition of this group also deeply affects the integrity of the molecule. The carbonyl group has the properties and can form isomolecular functions; the methyl group is non-molecular and has physical properties such as fat solubility of the molecule.
, N-acetyl-3,5-diiodotyrosine, because the iodine atom replaces the acetyl group, making it both multi-specific. It plays an important role in the synthesis of thyroid hormones.
What are the main uses of N-acetyl-3,5-diiodotyrosine?
N-acetyl-3,5-diiodotyrosine is an organic compound. It has important uses in many fields such as medicine.
In the process of medicine, first, it is related to the synthesis of thyroid hormones. In the process of thyroxine production, N-acetyl-3,5-diiodotyrosine can be a key intermediate. The thyroid needs iodine to synthesize thyroid hormones, and the iodine atoms contained in this compound can participate in the fine structure of thyroid hormones. When iodine deficiency occurs, thyroid hormone synthesis is blocked, and the body may have goiter and other diseases. The existence of this compound is of great significance in maintaining the normal synthesis of thyroid hormones.
Second, in the field of drug development, this compound can also be used. Because its structure contains special iodine atoms and acetyl groups and other functional groups, its structure can be modified by chemical modification to develop new drugs with specific pharmacological activities. It can enhance the affinity between drugs and targets, or optimize pharmacokinetic properties, such as improving the absorption, distribution, metabolism and excretion characteristics of drugs, so as to develop drugs with better curative effect and lower side effects.
Third, in the field of physiological research, it is helpful to gain in-depth insight into the physiological mechanism of the thyroid. By studying the metabolic pathway and regulatory mechanism of N-acetyl-3,5-diiodotyrosine in vivo, researchers can better understand the relationship between thyroid hormones and the body's growth, development, and metabolic regulation, providing a key theoretical basis for the pathogenesis of related diseases and the formulation of prevention and control strategies.
What is the production method of N-acetyl-3,5-diiodotyrosine?
N-acetyl-3,5-diiodotyrosine is also an organic compound. The common methods for its preparation have several ends.
First, tyrosine is used as the starting material. The reaction of tyrosine with acetic anhydride can acetylate the amino group to obtain N-acetyltyrosine. Afterwards, the product is placed in an appropriate reaction system and iodized with an iodine source (such as iodine elemental substance, mixed system of potassium iodide and hydrogen peroxide, etc.). Under suitable conditions such as temperature, pH and reaction time, iodine atoms can selectively replace hydrogen atoms at positions 3 and 5 on the benzene ring to obtain N-acetyl-3,5-diiodotyrosine. In this process, the regulation of temperature is very critical. If the temperature is too high, it may cause an increase in side reactions and reduce the purity of the product; if the temperature is too low, the reaction rate will be slow and take a long time.
Second, the protective group strategy can also be started. First, the carboxyl and amino groups of tyrosine are protected, and suitable protective groups are selected to stabilize them in subsequent reactions. Subsequently, the iodization operation is carried out for the benzene ring. After the iodization reaction is completed, the protective groups are removed in sequence, and N-acetyl-3,5-diiodotyrosine can also be obtained. Although this approach is a little complicated, it can effectively improve the selectivity of the reaction and the purity of the product.
Or other compounds of similar structures are used as starting materials and converted through multi-step reactions. However, no matter what method, precise control of the reaction conditions, such as the proportion of reactants, the choice of reaction solvents, and the use of catalysts, etc., can be used to prepare N-acetyl-3,5-diiodotyrosine efficiently and with high purity.
How safe is N-acetyl-3,5-diiodotyrosine?
N-acetyl-3,5-diiodotyrosine is also an organic compound. Its safety is related to many aspects, as follows.
From the perspective of chemical structure, the compound contains groups such as acetyl and iodine atoms. Acetyl groups are usually relatively stable, but iodine atoms are active, or their chemical properties are special. This special structure makes it possible to undergo chemical reactions under specific conditions, such as forming new bonds with other substances, which affects its stability and safety.
From the perspective of toxicity, although there is no extensive and detailed study, some iodine-containing organic compounds may be toxic. Excessive intake of iodine has adverse effects on human thyroid function. If N-acetyl-3,5-diiodotyrosine enters the biological body, it will cause health problems such as thyroid diseases due to its iodine structure or interference with physiological processes such as thyroid hormone synthesis.
In terms of environmental impact, if the substance enters the environment, its degradation process and products need attention. Due to its complex structure, it is difficult to be rapidly decomposed by microorganisms in the natural environment, long-term residue, or passed through the food chain, causing potential harm to the ecosystem. For example, it affects the survival and metabolism of aquatic organisms and soil microorganisms.
In industrial production and use, improper operation also poses risks. The synthesis process involves the control of chemical reagents and reaction conditions. If the raw materials leak and the reaction goes out of control, it will not only affect the product quality, but also the chemical reagents themselves may be corrosive and irritating, threatening the safety of operators and the surrounding environment.
In short, the safety of N-acetyl-3,5-diiodotyrosine requires comprehensive consideration of chemical structure, toxicity, environmental impact and production and use. Although current research may not be complete, it should be treated with caution and investigated in depth to ensure the safety of its application in various fields.
What is the price range of N-acetyl-3,5-diiodotyrosine in the market?
N-acetyl-3,5-diiodotyrosine is one of the organic compounds. It is difficult to say for sure in the market price range. The price of this compound often varies due to many factors.
First, the purity has a huge impact. If the purity is extremely high, it is almost flawless, and the price is high; if it contains impurities and the purity is not high, the price is slightly lower. Second, the scale of production is also the key. In large-scale production, due to economies of scale, the unit cost may be reduced, and the price will also slow down; if it is prepared on a small scale, the cost is high, and the price is high. Third, the market supply and demand situation determines the price. If there are many people who need it, but the supply is scarce, the price will rise; if the market is saturated and the supply is abundant, the price may be downward.
In addition, different suppliers have different pricing strategies. Well-known and reputable suppliers may have higher prices for their products due to quality assurance and comprehensive after-sales services; while new entrants to the market or smaller suppliers may compete for share or have price advantages.
Therefore, in order to know the exact price range of N-acetyl-3,5-diiodotyrosine, it is necessary to carefully investigate the factors of purity, production scale, supply and demand, and suppliers, and conduct detailed market research to obtain a more accurate price range.