N-Boc-3-Amino-4-Iodopyridine

N-boc-3-amino-4-iodopyridine is an important compound in organic synthesis and has a wide range of uses.
In the field of medicinal chemistry, this compound is often a key intermediate for the preparation of drug molecules with specific biological activities. Due to the reactivity of both amino and iodine atoms in its structure, the core skeleton of drug molecules can be constructed through various chemical reactions, such as nucleophilic substitution reactions, iodine atoms can be replaced by other functional groups, thereby introducing groups that have important effects on drug activity, selectivity and metabolic properties; amino groups can participate in the formation of amide bonds, etc., which help to construct complex drug structures and help to develop new antibacterial, anti-tumor and other drugs.
In the field of materials science, N-boc-3-amino-4-iodopyridine can participate in the synthesis of functional materials. Through appropriate reactions, it is introduced into the polymer chain to endow the material with special properties, such as changing the optical and electrical properties of the material. Due to the unique properties of iodine atoms and amino groups, it may be able to regulate the interaction between the molecules of the material, thereby improving the physical properties such as solubility and crystallinity of the material, providing the possibility for the preparation of new optoelectronic materials, sensor materials, etc.
In addition, in the study of organic synthesis methodology, it is used as a model substrate to explore new reaction pathways and catalytic systems. Scientists can use its reaction characteristics to explore novel reaction conditions, optimize reaction steps, improve reaction efficiency and selectivity, and provide ideas and methods for the development of organic synthetic chemistry. In short, N-boc-3-amino-4-iodopyridine plays an important role in many fields, promoting the development of related disciplines and technological progress.

The synthesis method of N-Boc-3-amino-4-iodopyridine is a key point of concern in the field of organic synthesis. One method is to use 3-amino-4-iodopyridine as the starting material and react with Boc anhydride under suitable reaction conditions. This reaction often needs to be carried out in an alkaline environment, and alkali substances such as triethylamine can create this environment. The action of the base promotes the deprotonation of the amino group of 3-amino-4-iodopyridine, thereby enhancing its nucleophilicity, so that it is easier to undergo nucleophilic substitution reaction with the carbonyl group of Boc anhydride. The reaction solvent can be selected from common organic solvents such as dichloromethane, which have good solubility to both the reactants and the products, and can make the reaction proceed smoothly. The reaction temperature and time are also key factors. The reaction is usually in the range of low temperature to room temperature for several hours. After monitoring the reaction process, the reaction can be stopped when the raw materials are exhausted. Subsequent purification methods such as extraction, washing, drying, and column chromatography can obtain pure N-Boc-3-amino-4-iodine pyridine products.
There is another synthetic way. The pyridine ring can be modified first to construct a pyridine derivative with a specific substituent, and then the Boc protecting group and iodine atom can be introduced. For example, pyridine can be used as the starting material, and a suitable substituent can be introduced through a specific electrophilic substitution reaction. Then, through a series of reactions, amino and iodine atoms can be gradually introduced, and finally the amino group can be protected by Boc anhydride. Although this method is a little complicated, under certain circumstances, the reaction check point and product structure may be more accurately controlled.
Furthermore, it can also be synthesized by means of transition metal-catalyzed reactions. For example, by using palladium-catalyzed cross-coupling reaction, a pyridine derivative containing amino and Boc protecting groups is used as a substrate to react with iodine substitutes in the presence of palladium catalysts and ligands, so that iodine atoms are introduced at specific positions of the pyridine ring to achieve the synthesis of N-Boc-3-amino-4-iodine. This method requires fine regulation of catalysts, ligands, reaction conditions, etc. to ensure the high efficiency and selectivity of the reaction.

I look at your question, but I am inquiring about the market price of N-boc-3-amino-4-iodopyridine. However, the price of this chemical varies with the supply and demand of the market, the amount of production, and the quality. It is difficult to determine.
In the past, although this thing was not included in Tiangong Kaiwu, the price of the thing also showed that it varies from time to place. Like all kinds of materials, when the production is at its peak, the price will tend to decline; when it is needed, the price will tend to rise.
Today N-boc-3-amino-4-iodopyridine, if in the ordinary chemical market, its price may vary according to quantity. Buy in small quantities, ranging from tens to hundreds of yuan per gram; if block trade, due to cost reduction, the price should be reduced. And produced by different manufacturers, due to quality differences, prices are also different. High quality, the price is higher; those with less quality, the price is slightly lower. And regional differences, such as bustling commercial ports and remote places, the price is also different. Therefore, if you want to know the exact price, you must consult the chemical supplier and compare their quotations to get a near-real price.

N-boc-3-amino-4-iodopyridine is an important compound in the field of organic synthesis. Its physical and chemical properties play a crucial role in the process of organic synthesis.
Looking at its physical properties, under normal conditions, N-boc-3-amino-4-iodopyridine is mostly in a solid state, but its exact physical form may vary depending on the specific preparation process and purity. Its melting point is one of the key indicators to measure its physical properties. The level of melting point depends on its phase transition at a specific temperature, which in turn affects its operating conditions in the synthesis reaction. Sadly, without accurate melting point data, it can be inferred that its melting point should be adapted to the common organic reaction temperature range, which is convenient for heating or cooling to achieve the best state of its participation in the reaction.
As for its solubility, this compound exhibits specific solubility in common organic solvents. Generally speaking, in polar organic solvents, such as dichloromethane, N, N-dimethylformamide (DMF), etc., its solubility is quite good. Dichloromethane has good solubility and a moderate boiling point, which is easy to be separated by distillation and other means after the reaction. N-boc-3-amino-4-iodopyridine can form a suitable interaction with dichloromethane molecules to dissolve it. DMF, because of its strong polarity, can form hydrogen bonds or other polar interactions with the compound, so that it can be uniformly dispersed in solvents in a molecular state, which facilitates its participation in various homogeneous reactions.
On its chemical properties, the first one is the amino group and iodine atoms it contains. Amino, with nucleophilic properties, can participate in many nucleophilic substitution reactions. Under suitable reaction conditions, amino groups can attack the electron-deficient center of electrophilic reagents, realize the connection between nitrogen atoms and other atoms or groups, and then build more complex organic molecular structures. Iodine atoms are also active functional groups, and can participate in many typical reactions of halogenated hydrocarbons, such as coupling reactions. In palladium-catalyzed coupling reaction systems, iodine atoms can react with other compounds containing unsaturated bonds under the action of catalysts to realize the construction of carbon-carbon bonds or carbon-heteroatom bonds. This is an important strategy for expanding the molecular skeleton in organic synthesis.
Furthermore, N-boc groups also have a significant impact on the chemical properties of the compound. The Boc group, tert-butoxycarbonyl, has the function of protecting the amino group. In complex organic synthesis routes, when the amino group needs to be selectively reacted, the Boc group can prevent the amino group from participating in the unexpected reaction prematurely. After the specific reaction step is completed, it can be removed under mild conditions to restore the activity of the amino group and participate in the subsequent reaction. This protection and deprotection strategy greatly enhances the selectivity and controllability of organic synthesis.
The physicochemical properties of N-boc-3-amino-4-iodopyridine lay the foundation for its wide application in the field of organic synthetic chemistry. Through in-depth understanding and clever use of its properties, organic chemists have been able to design and implement many exquisite synthesis routes, creating a wide variety of organic compounds.

N-boc-3-amino-4-iodopyridine is a compound commonly used in organic synthesis. During storage and transportation, the following things should be paid attention to.
First storage conditions. Due to its nature or sensitivity to environmental factors, it should be stored in a dry, cool and well-ventilated place. High humidity can easily cause it to get damp, or cause reactions such as hydrolysis, which can damage its purity and quality. Excessive temperature may also promote chemical reactions, causing it to decompose or deteriorate. Therefore, precise control of the temperature and humidity of the storage environment is extremely critical.
Second, packaging. It needs to be packaged with suitable materials, such as glass bottles, plastic bottles or aluminum foil bags. The packaging must be well sealed to prevent contact with air, moisture, etc. For easily oxidized ingredients, consider filling with inert gases, such as nitrogen, to create an oxygen-free environment and increase its stability.
When transporting, avoid violent vibration and collision. Because it may be in the form of crystals or powders, violent vibration or damage to the package, causing it to leak. And vibration, collision or cause internal structural changes, affecting chemical properties.
Furthermore, follow relevant regulations and standards. Transporting such chemical substances must be carried out in strict accordance with chemical transportation regulations to ensure safety and compliance during transportation. Transport personnel also need to be professionally trained and familiar with emergency handling methods to prevent accidents from happening.
The storage and transportation of N-boc-3-amino-4-iodopyridine requires comprehensive consideration of the environment, packaging, transportation operations, and regulatory compliance to ensure its stability and transportation safety.