What is the chemical structure of N, n '-bis (2,3-dihydroxypropyl) -2,4,6-triiodo-5- (n-methylglycolamido) isophthalamide?

This is an organic compound, or the Chinese name is N, N '-bis (2,3-dihydroxypropyl) -2,4,6-triiodine-5- (N-methylglyceramide) isophthalamide. To clarify its chemical structure, it is necessary to analyze it from the naming.

"N, N' -bis (2,3-dihydroxypropyl) ", which means that there are two 2,3-dihydroxypropyl groups in the molecule connected to the nitrogen atom. This propyl group contains two hydroxyl groups, which adds hydrophilicity to the molecule.

"2,4,6-triiodine" indicates the introduction of iodine atoms at the 2,4,6 positions of the benzene ring. The atomic weight of iodine atoms is large, which will affect the physical and chemical properties of molecules, such as increasing the density and changing the distribution of electron clouds.

"5- (N-methylglyceramide group) " means that there is an N-methylglyceramide group attached to the 5 position of the benzene ring. N-methylglyceramide group contains amide bonds and has certain stability, and the introduction of methyl groups changes the electronic effect and steric resistance of the group.

"Isophthalamide" reveals that the main skeleton of the molecule is isophthalamide, that is, the two carboxyl groups at the interposition of the benzene ring form an amide bond with the amino group.

In summary, the chemical structure of this compound is based on isophthalamide as the skeleton. There are iodine atoms at positions 2, 4, and 6 on the benzene ring, N-methylglycinamide group at position 5, and N atom with two 2,3-dihydroxypropyl groups. This structure endows the compound with unique physical, chemical and biological activities, and may have potential uses in the fields of medicine, materials, etc.

What are the main uses of N, n '-bis (2,3-dihydroxypropyl) -2,4,6-triiodo-5- (n-methylglycolamido) isophthalamide?

N, N '-bis (2,3-dihydroxypropyl) -2,4,6-triiodine-5- (N-methylglycinamide) isophthalamide, this substance is a very important chemical substance, which has its uses in many fields.

In the field of medical imaging, it is a key component of contrast agents. Because the molecule is rich in iodine atoms, iodine has a high atomic number and has a strong X-ray absorption capacity. Therefore, the contrast agent made on the basis of this substance can clearly outline the outline and shape of specific organs or tissues after being injected into the human body, which can help doctors accurately diagnose diseases, such as vascular diseases and organ structural abnormalities, and greatly improve the accuracy of disease diagnosis.

In drug research and development, due to its unique chemical structure, it may be used as a lead compound. By modifying and modifying its structure, researchers explore the synthesis of drug molecules with novel pharmacological activities, providing a possible path for the creation of new therapeutic drugs to meet the challenges of various diseases.

In the field of materials science, this substance may be used to prepare special functional materials. The hydroxyl groups, amide groups and other functional groups contained in its structure endow the material with specific chemical activities and physical properties, which can be used to prepare adsorption materials, separation membrane materials, etc., showing potential application value in the fields of substance separation, enrichment and catalysis.

From this perspective, N, N '-bis (2,3-dihydroxypropyl) -2,4,6-triiodine-5- (N-methylglycylamino) isophthalamide plays an important role in many fields such as medicine, drug development and materials science, and is of great significance to promote the development of various fields.

How safe is N, n '-bis (2,3-dihydroxypropyl) -2,4,6-triiodo-5- (n-methylglycolamido) isophthalamide?

N, N '-bis (2,3-dihydroxypropyl) -2,4,6-triiodine-5- (N-methylglycinamide) isophthalamide, this is a chemical substance. Its safety is related to many aspects, let me tell you one by one.

In terms of toxicity, after many studies, its acute toxicity is relatively low. In animal experiments, high doses of this substance were given, and no immediate serious toxicity reactions were found, such as severe behavioral abnormalities, significant pathological changes in important organs, etc. However, toxicity testing still needs to be meticulous, taking into account differences in different animal species and the potential for accumulated toxicity.

Re-discuss the impact on the environment. The degradation characteristics of this chemical in the environment still need to be further explored. If it is difficult to degrade, it may accumulate in the environment and affect the balance of the ecosystem. And its impact on aquatic organisms, soil microorganisms, etc. in environmental media such as water and soil is not fully clear. It may be necessary to simulate natural environmental conditions and carry out various ecotoxicological experiments to gain insight into its potential harm to environmental organisms.

And consider its safety in specific application scenarios. If used in medical imaging and other fields, it is necessary to pay attention to its interaction with human tissues and cells. Although it is used as a contrast agent, it is expected to develop efficiently and cause little harm to the human body. However, there are large differences in human individuals, and some individuals may have adverse reactions such as allergies to them. Therefore, before clinical application, strict safety assessment is indispensable, including tolerance testing for different populations, latent risk assessment for long-term use, etc.

Overall, although some current studies have shown that it has a certain safety basis, further detailed studies are needed in terms of toxicity, environmental impact, human application, etc., to fully know its safety and ensure that there is no significant harm to life, health and the environment during application.

How is N, n '-bis (2,3-dihydroxypropyl) -2,4,6-triiodo-5- (n-methylglycolamido) isophthalamide produced?

N, N '-bis (2,3-dihydroxypropyl) -2,4,6-triiodine-5- (N-methylglycinamide) isophthalamide, which is the chemical name of the contrast agent iodoxanol. Its production process is complicated and delicate, let me explain in detail.

At the beginning, isophthalic acid is used as the basic raw material. Iodine atoms are ingeniously introduced into the structure of isophthalic acid through a specific chemical reaction, resulting in 2,4,6-triiodoisophthalic acid. This process requires precise control of reaction conditions, such as temperature, pH and reaction time. If there is a slight difference, the purity and yield of the product will be affected.

Then, 2,4,6-triiodoisophthalic acid and N-methylglyceramide under the catalysis of suitable catalysts, an amidation reaction occurs to generate 5- (N-methylglyceramide) - 2,4,6-triiodoisophthalic acid. The key to this step is to select an efficient and selective catalyst to promote the smooth progress of the reaction in the desired direction.

Furthermore, the reaction of 5- (N-methylglyceramide) - 2,4,6-triiodoisophthalic acid with epichlorohydrin in an alkaline environment has undergone a series of changes such as ring opening and ring closing, and finally N, N '-bis (2,3-dihydroxypropyl) - 2,4,6-triiodoiso-5 - (N-methylglyceramide) isophthalamide. The alkaline conditions at this stage need to be carefully controlled, and either too strong or too weak is unfavorable to the reaction.

After each step of reaction, it needs to be separated and purified. Commonly used methods include crystallization, extraction, column chromatography, etc., to remove impurities and improve the purity of the product. Many steps are closely connected, and omissions in any link may cause the final product to fail to meet the standard. The production of this substance requires exquisite skills and rigorous attitude to produce high-quality N, N '-bis (2,3-dihydroxypropyl) -2,4,6-triiodine-5 - (N-methylglycylamido) isophthalamide.

What are the advantages of N, n '-bis (2,3-dihydroxypropyl) -2,4,6-triiodo-5- (n-methylglycolamido) isophthalamide over other similar products?

N, N '-bis (2,3-dihydroxypropyl) -2,4,6-triiodine-5- (N-methylglycinamide) isophthalamide, this drug has significant advantages over other similar products.

First, its developing performance is excellent. This drug contains a triiodine structure, high iodine atomic weight, strong X-ray absorption capacity, and can clearly outline the contours of tissues and organs in the body. The imaging is clear, and the fine structure is complete, which can help doctors make accurate diagnoses. For example, when angiography, it can clearly show blood vessels and lesions, unlike other drugs, which are blurred in imaging and easy to cause misdiagnosis and missed diagnosis.

Second, the safety is quite good. Hydrophilic groups such as dihydroxypropyl are introduced into the molecule to reduce fat solubility, reduce binding with lipids, and reduce toxicity to the nervous system and cardiovascular system. After a large number of clinical verifications, the incidence of adverse reactions is low, even in sensitive patients, it is well tolerated, without serious discomfort, adding protection to patient safety.

Third, excellent stability. Stable chemical structure, not easy to decompose and deteriorate during storage, long valid period, and guaranteed drug quality. Under different environmental conditions, it can maintain the content and performance of active ingredients and ensure stable effect in medical applications. Unlike some similar products, due to storage conditions, it is easy to deactivate and affect the efficacy.

Fourth, it has a wide range of applications. Due to its unique chemical structure and good performance, it is suitable for a variety of imaging tests, such as intravenous urography, cardiovascular angiography, CT enhanced scanning, etc., providing more options for clinical diagnosis and meeting the needs of different patients and diseases. However, other similar products may only be suitable for specific examinations, limiting their application.