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What is the chemical structure of O- (4-hydroxy-3-iodophenyl) -3,5-diiodo-l-tyrosine?
O- (4-hydroxy-3-iodophenyl) -3,5-diiodol-L-tyrosine is one of the organic compounds. Its chemical structure contains the basic structure of tyrosine, which is an amino acid with amino and carboxyl groups.
In this compound, the tyrosine phenyl ring contains iodine atoms and hydroxyl substituents at specific positions. Specifically, "O- (4-hydroxy-3-iodophenyl) " indicates that the phenolic hydroxyl oxygen atom of tyrosine is connected with a 4-hydroxy-3-iodophenyl group. This phenyl group has a hydroxyl group (-OH) at the 4th position and an iodine atom (-I) at the 3rd position.
Furthermore, "3,5-diiodine" shows that the 3rd and 5th positions of the tyrosine phenyl ring are replaced by iodine atoms. Overall, the chemical structure of this compound is modified by specific substituents on the tyrosine basic structure. The introduction of multiple iodine atoms and hydroxyl groups endows it with unique chemical properties and potential biological activities. Such structural properties may be of great significance in the fields of medicinal chemistry, biochemistry, etc., or affect its interaction with biological macromolecules, such as binding with proteins and enzymes, etc., and then exhibit specific physiological functions or pharmacological effects.
What are the main physical properties of O- (4-hydroxy-3-iodophenyl) -3,5-diiodo-l-tyrosine?
O- (4-hydroxy-3-iodophenyl) -3,5-diiodine-L-tyrosine is an organic compound with special physical properties. Its appearance is often white to light yellow crystalline powder, which is derived from the interaction and arrangement of molecules. Under normal temperature and pressure, the properties of this substance are quite stable, and the chemical bonds between atoms in the molecular structure are stable, and it is not easy to spontaneously produce chemical changes.
When it comes to solubility, this compound is slightly soluble in water. Although it contains polar groups such as hydroxyl groups in its molecules, it can form hydrogen bonds with water molecules, but at the same time the presence of many iodine atoms increases the non-polar part of the molecule, resulting in limited interaction with water as a whole. However, it is soluble in some organic solvents, such as dimethyl sulfoxide (DMSO), dichloromethane, etc. This is because these organic solvents can form similar intermolecular forces with the compound molecules, thereby promoting dissolution.
Its melting point is also an important physical property. Experimentally determined, the melting point of the substance is in a specific temperature range, which is determined by the intermolecular forces, including van der Waals forces, hydrogen bonds, etc. When the temperature rises to the melting point, the molecule obtains enough energy to overcome these forces, and then transitions from a solid state to a liquid state.
In addition, the compound also has certain optical properties. Due to the presence of iodine atoms in the molecular structure, they will absorb and emit light of specific wavelengths, presenting unique absorption and emission peaks in spectral analysis. This property is used in the field of analytical chemistry to identify and quantify the substance.
What are the common uses of O- (4-hydroxy-3-iodophenyl) -3,5-diiodo-l-tyrosine?
O- (4-hydroxy-3-iodophenyl) -3,5-diiodol-L-tyrosine, this is an organic compound. Its common use is related to the field of pharmaceutical and chemical industry.
In the field of medicine, this compound is often used as a key intermediate in the synthesis of thyroid hormones. Thyroid hormones are essential for human growth and development and metabolism regulation. Taking the process of thyroxine synthesis as an example, iodine atoms undergo a series of biochemical reactions to precisely embed tyrosine residues, thereby constructing complex thyroid hormone structures. The specific iodine and hydroxyl structures of this compound are of great significance for simulating and promoting thyroid hormone synthesis, which helps scientists to deeply analyze the physiological mechanism of thyroid gland and develop drugs for the treatment of related diseases.
In the chemical industry, due to its unique chemical structure, it can act as a building block for organic synthesis. With the activity of iodine atoms and hydroxyl groups, more complex organic molecular structures can be constructed through many chemical reactions, such as nucleophilic substitution, coupling reactions, etc. For example, in the research and development of new materials, organic materials with special photoelectric properties can be synthesized on this basis, which can be used to prepare organic Light Emitting Diodes, solar cells and other devices, injecting new impetus into the development of materials science.
In summary, O- (4-hydroxy-3-iodophenyl) -3,5-diiodol-L-tyrosine plays a key role in the field of pharmaceutical and chemical industry, and has made great contributions to related scientific research and industrial development.
What are the preparation methods of O- (4-hydroxy-3-iodophenyl) -3,5-diiodo-l-tyrosine
To prepare O- (4-hydroxy-3-iodophenyl) -3,5-diiodine-L-tyrosine, there are two methods. First, start with L-tyrosine and obtain it by iodization. Place L-tyrosine in an appropriate reaction vessel, add an appropriate amount of iodine source, such as iodine elemental or iodine-containing compounds, and at a suitable temperature, pH and reaction time, iodine atoms gradually replace hydrogen atoms at specific positions on the benzene ring. This process requires fine regulation of the reaction conditions. If the temperature is too high or the amount of iodine is too high, it is easy to cause excessive iodization and the product is impure; if the temperature is too low or the amount of iodine is insufficient, the reaction is difficult to proceed fully and the yield is low.
Second, the 4-hydroxy-3-iodobenzene derivative is prepared first, and then reacted with the compound containing L-tyrosine structure. The 4-hydroxy-3-iodobenzene derivative is synthesized through a series of reactions, and then it is linked with another reactant containing L-tyrosine structure under specific catalyst and reaction conditions to form the target product. The key to this approach lies in the precise control of the intermediate in each step of the reaction to ensure its structure and purity, so that the final product can reach the expected quality. During the synthesis process, a variety of analytical methods, such as chromatography, spectroscopy, etc., are required to monitor the reaction process to ensure the purity and structural accuracy of the product at each step, and then to obtain high-purity O- (4-hydroxy-3-iodophenyl) -3,5-diiodol-L-tyrosine.
What are the precautions for O- (4-hydroxy-3-iodophenyl) -3,5-diiodo-l-tyrosine during storage and use?
For O- (4-hydroxy-3-iodophenyl) -3,5-diiodol-L-tyrosine, there are many matters to be paid attention to when storing and using.
One is related to storage. This substance is quite sensitive to environmental conditions and should be stored in a cool, dry and well-ventilated place. Do not place it in a high temperature or humid place. High temperature can easily cause its chemical structure to change, and humid may cause deliquescence and cause it to deteriorate. In case of summer heat, be sure to ensure that the storage environment temperature is suitable and do not expose it to direct sunlight. And it should be stored separately from oxidants, acids and other substances. Because of its active chemical properties, contact with these substances or chemical reactions will damage its quality.
Second, as for use. Before use, the operator must be familiar with its characteristics and safety precautions. Wear appropriate protective equipment, such as gloves, goggles, etc., to prevent it from coming into contact with the skin and eyes. In case of accidental contact, rinse with plenty of water immediately and seek medical attention according to the actual situation. During use, the operation should be carried out in a fume hood to avoid inhaling its dust or volatiles, which may irritate or even damage the respiratory tract. When configuring solutions and other operations, be sure to strictly follow the prescribed procedures, and control the concentration and dosage to ensure the accuracy and safety of the experiment or production. In addition, after use, the remaining substances should be properly disposed of and should not be discarded at will to prevent environmental pollution.