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What is the chemical structure of O- (4-hydroxyphenyl) -3,5-diiodo-l-tyrosine?
The chemical structure of O- (4-hydroxyphenyl) -3,5-diiodol-L-tyrosine needs to be analyzed in a fine state.
This compound is tyrosine-based. Tyrosine has an amino group (-NH ²) and a carboxyl group (-COOH), and is connected to a benzene ring side chain at an α-carbon atom. This is its basic skeleton, which is an important amino acid unit composed of proteins. It is chiral. L-type is a common configuration in natural biological systems.
Its O - (4 -hydroxyphenyl) part means that the 4-position of the benzene ring is replaced by the hydroxyl group (-OH). Hydroxyl groups, hydrophilic groups, can also participate in the formation of hydrogen bonds, which have a great impact on the solubility and reactivity of compounds.
Furthermore, 3,5-diiodine, that is, the 3 and 5 positions of the benzene ring are occupied by iodine atoms (I). Iodine atoms are relatively heavy and have a certain electronegativity. After introducing iodine atoms, the electron cloud distribution of molecules can be significantly changed, which in turn affects the polarity and steric resistance of molecules. It may change the intermolecular forces, which are manifested in chemical reactions and crystal structures.
In this way, the chemical structure of O- (4-hydroxyphenyl) -3,5-diiodol-L-tyrosine is composed of the parent tyrosine, together with 4-hydroxyphenyl, 3,5-diiodol and other substituents. Each part interacts to jointly determine the unique chemical properties and biological activities of this compound.
What are the main uses of O- (4-hydroxyphenyl) -3,5-diodol-l-tyrosine?
O- (4-hydroxyphenyl) -3,5-diiodine-L-tyrosine is also an organic compound. Its main uses are widely involved in the field of medical and biochemical research.
In the road of medicine, one of them is related to the study of thyroid hormone synthesis. The mechanism of thyroid hormone synthesis is particularly complex, and this compound plays a key role in it. It is an important intermediate for thyroxine biosynthesis, just like a key brick and stone to build a magnificent building. By studying its participation in thyroxine synthesis, doctors and researchers can gain in-depth insight into the physiological and pathological mechanisms of the thyroid, and then find accurate diagnosis and effective treatment for thyroid-related diseases, such as hyperthyroidism and hypothyroidism.
Second, in drug research and development, this compound has the potential to become a lead compound. Researchers can use delicate molecular modification and modification techniques according to their chemical structure and biological activity, hoping to create new drugs with better efficacy and less side effects. Just like a craftsman carving jade, carefully designed and optimized, it is expected to create more ideal therapeutic drugs for the well-being of patients.
In the field of biochemical research, it can be used as a probe to help scientists detect the activity of proteins and enzymes. Due to the specific structure of the compound, it can interact specifically with specific proteins or enzymes, like a key and a lock. In this way, researchers can clarify the role of proteins and enzymes in biochemical reactions, analyze the delicate processes of life activities, such as cell metabolism, signal transduction, etc., and contribute to the basic research of life science, helping humans explore the mysteries of life to a deeper level.
What are the physical properties of O- (4-hydroxyphenyl) -3,5-diiodo-l-tyrosine?
O- (4-hydroxyphenyl) -3,5-diiodine-L-tyrosine This substance has unique physical properties. Its shape may be white to light yellow crystalline powder, fine and uniform, looking like the end of coagulation, slightly glossy under light.
When it comes to solubility, this substance is slightly soluble in water and drifts like a cloud in water. It can only be dissolved a little, and it is difficult to form a clear liquid. However, in organic solvents, such as alcohols, its solubility is slightly better, and it can melt with alcohols and gradually form a homogeneous state.
Its melting point is quite high, and it needs to be heated moderately to melt. When heated to a specific temperature, about [specific melting point value], it begins to slow down from solid to liquid, like ice disappearing under warm sun. This property is crucial for identification and purification.
And its stability also has characteristics. It can be stored for a long time in a dry place at room temperature, and its properties are not easy to change. However, if exposed to strong light, high temperature or high humidity, it is prone to changes or structural changes, which affect its inherent properties. Therefore, it needs to be properly stored in a cool and dry place to avoid all adverse environmental factors. These are all important physical properties of O- (4-hydroxyphenyl) -3,5-diiodol-L-tyrosine, which need to be carefully considered in relevant research and applications.
What are the synthesis methods of O- (4-hydroxyphenyl) -3,5-diodol-l-tyrosine?
To prepare O- (4-hydroxyphenyl) -3,5-diiodol-L-tyrosine, there are many methods, and the above methods are common.
One is a chemical synthesis method. With L-tyrosine as the starting material, the phenolic hydroxyl group is first protected to prevent it from participating in the reaction without reason and causing the product to be impure. Commonly used protective groups include benzyl, etc., through suitable reaction conditions, the benzyl group is connected to the phenolic hydroxyl group. Then, the protected L-tyrosine is reacted with the iodine source to achieve iodization at 3,5 positions. The commonly used iodine sources such as the mixed system of iodine elemental substance and potassium iodide can proceed smoothly under the action of suitable solvents and catalysts. After the iodization is completed, the protective group is removed under suitable conditions to restore the phenolic hydroxyl group, and the target product O- (4-hydroxyphenyl) -3,5-diiodine-L-tyrosine is obtained. In this process, the control of the reaction conditions at each step is extremely critical. Temperature, reaction time, and the proportion of reactants will all affect the purity and yield of the product.
The second is biosynthesis. Synthesize using the catalytic properties of microorganisms or enzymes. The enzyme system in some microorganisms can be modified by iodization and hydroxylation of specific substrates. Microorganisms with such abilities can be screened out and their culture conditions can be optimized, such as medium composition, temperature, pH value, etc., so that microorganisms can express relevant enzymes efficiently in a suitable environment. Feed microorganisms with suitable substrates, and eventually generate O- (4-hydroxyphenyl) -3,5-diiodine-L-tyrosine through complex metabolic pathways in microorganisms. This method is green and environmentally friendly, and has high selectivity, but it is difficult to separate and purify microbial culture and products.
Another semi-synthesis method combines the strengths of chemical synthesis and biosynthesis. First, some key intermediates are prepared by chemical synthesis, and then biological enzymes or microorganisms are used to modify the intermediates to obtain the target product. In this way, the drawbacks of too many chemical synthesis steps can be avoided, and the advantages of biosynthesis can also be exerted to improve product quality and yield.
These various synthesis methods have their own advantages and disadvantages. In practical application, the appropriate method should be comprehensively selected according to specific needs, cost considerations, product quality requirements and other factors.
What is the price range of O- (4-hydroxyphenyl) -3,5-diiodo-l-tyrosine in the market?
I have not heard of the price of "O- (4-hydroxyphenyl) -3,5-diiodo-l-tyrosine" in the market. This is a very professional chemical substance, and its price often depends on a variety of factors.
First, purity is the key. If the purity is very high, it is suitable for fine scientific research or special medical preparation, and the price must be high; if the purity is slightly lower, it is used in ordinary experiments or industrial primary processes, and the price may be slightly cheaper.
Second, the situation of supply and demand also affects its price. If the demand for this material in the scientific research field increases sharply and the supply is limited, the price will rise; conversely, if the supply is abundant and the demand is low, the price may decline.
Third, the difficulty of preparation also affects. If its synthesis requires complicated steps, special reagents and harsh conditions, the cost will be high, and the price will follow; if the preparation is relatively simple, the price may be low.
Furthermore, the state of market competition cannot be ignored. Many suppliers compete for the market, in order to win customers, or they may reduce prices; if the market is almost monopolized, the price may be controlled by the dominant person.
However, I have searched all the books I know, but I have not been able to obtain the exact price range. To know the details, or to consult chemical reagent suppliers, scientific research materials trading platforms, or people who specialize in the industry, they may be able to tell the real price according to the current market conditions.