As a leading O-(4-Hydroxyphenyl)-3,5-Diiodotyrosine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of O- (4-hydroxyphenyl) -3,5-diiodotyrosine?
Alas! I want to know the chemical structure of "O- (4-hydroxyphenyl) -3,5-diiodotyrosine", and listen to me in detail.
This compound is also a derivative of tyrosine. Tyrosine, one of the amino acids, has an amino group (\ (- NH_ {2}\)) and a carboxyl group (\ (-COOH\)), which are respectively connected to the central carbon atom. The central carbon atom is complex with a hydrogen atom and a side chain group.
As for "O- (4-hydroxyphenyl) -3,5-diiodotyrosine", its side chain group is quite unique. The side chain is based on a benzene ring, and the 4-position of the benzene ring is added with a hydroxyl group (\ (-OH\)), which is called "4-hydroxyphenyl". And the 3-position and 5-position of the benzene ring each introduce an iodine atom, so it becomes a state of "3,5-diiodine".
Looking at its overall structure, tyrosine is used as the basic structure, and hydroxyl and iodine atoms are added through the modification of the side chain benzene ring, which makes the molecular properties and functions different from ordinary tyrosine. Hydroxyl groups are hydrophilic and can participate in the formation of hydrogen bonds, which affects the interaction between molecules. Iodine atoms are relatively heavy and have a certain electronegativity, which also affects the physical and chemical properties of molecules, such as polarity, melting point, boiling point, etc. This unique chemical structure endows the compound with specific biological activities and reaction characteristics, which may be of great significance in biochemical research and related fields.
What are the main physical properties of O- (4-hydroxyphenyl) -3,5-diiodotyrosine?
O- (4-hydroxyphenyl) -3,5-diiodotyrosine is an organic compound with unique physical properties. Looking at its properties, it is mostly white to light yellow crystalline powder under normal conditions. The texture is fine and the touch is slightly slippery, which is a significant feature in appearance.
When it comes to solubility, its solubility varies in organic solvents. In common organic solvents such as methanol and ethanol, it has a certain solubility and can be slowly dispersed to form a uniform solution; however, in water, the solubility is poor and only slightly soluble. The difference in solubility is due to the combined effect of hydrophilic and hydrophobic groups in its molecular structure.
After looking at the melting point again, the melting point is accurately determined to be in a specific temperature range, about [X] ° C. This melting point characteristic is stable and can be used as an important basis for identifying the substance. When the temperature rises to the melting point, the substance gradually melts from solid to liquid, and the process is relatively smooth.
In addition, its stability is also worthy of attention. In a dry environment at room temperature, the chemical properties of the substance are relatively stable, and it can be stored for a long time without obvious deterioration. However, if it is exposed to high temperature, high humidity or strong light irradiation, its molecular structure is easily affected, and decomposition or other chemical reactions may occur, causing its properties to change. The density of
is [X] g/cm ³ under the established conditions, which reflects the mass of the substance per unit volume and has important reference value for its measurement and mixing operations in practical applications.
In what fields is O- (4-hydroxyphenyl) -3,5-diiodotyrosine used?
O- (4-hydroxyphenyl) -3,5-diiodotyrosine is useful in various fields such as medicine and chemical industry.
In the field of medicine, it is related to the physiology and biochemistry of the thyroid gland. When thyroxine is synthesized, this compound is a key intermediary. Thyroglobulin contains tyrosine residues. After iodization and coupling reaction, it produces O- (4-hydroxyphenyl) -3,5-diiodotyrosine. Then, two molecules of this substance are coupled to form thyroxine (T4), or one molecule of this substance is coupled to one molecule of iodotyrosine to form triiodothyronine (T3). Thyroxine is essential for the regulation of human metabolism, growth and development, and nervous system function. Therefore, the study of this compound can provide a theoretical foundation and a new target for the diagnosis and treatment of thyroid diseases, such as hyperthyroidism and hypothyroidism.
In the chemical field, because it contains iodine atoms and phenolic hydroxyl groups, it has unique chemical activity. Iodine atoms make it have certain lipophilic and reactive activities, and phenolic hydroxyl groups can participate in many chemical reactions, such as esterification, etherification, etc. Therefore, it can be used as a raw material or intermediate for organic synthesis, used to prepare special polymer materials, functional dyes, etc. For example, after a specific chemical reaction, it is introduced into the polymer skeleton to endow the material with special optical, electrical or biocompatibility properties, which has great potential in the field of advanced materials research and development.
From this perspective, although O- (4-hydroxyphenyl) -3,5-diiodotyrosine is tiny, it plays a significant role in the fields of medicine and chemical industry, with far-reaching influence.
What are the methods for preparing O- (4-hydroxyphenyl) -3,5-diiodotyrosine?
O- (4 -hydroxyphenyl) -3,5 -diiodotyrosine, the method of preparation is as follows:
First, tyrosine is used as the starting material. Tyrosine is a common raw material in the field of organic synthesis, and it has an amino group and a carboxyl group, which can be used as the activity check point of the reaction. First, take an appropriate amount of tyrosine and dissolve it into an appropriate solvent, such as polar water or alcohol solvent, to facilitate the reaction.
Second, introduce iodine atoms. An iodine substitution reaction can be adopted, using iodine elemental substance (I -2) or iodine substitution reagents such as N-iodosuccinimide (NIS) as the iodine source. In the reaction system, an appropriate amount of catalyst, such as Lewis acid, is added to promote the selective replacement of hydrogen atoms at positions 3,5 on the tyrosine phenyl ring by iodine atoms. This step requires temperature control, depending on the nature of the reagent and catalyst used, the temperature is usually between 0 ° C and 50 ° C to ensure the smooth reaction and the purity of the product.
Third, 4-hydroxyphenyl is introduced. It can be achieved by nucleophilic substitution or coupling reaction. If nucleophilic substitution is adopted, the carboxyl or amino groups on the tyrosine are properly protected to prevent it from interfering in the reaction. Select a reagent with 4-hydroxyphenyl and react with iodine-substituted tyrosine under basic conditions. If a coupling reaction is used, such as Suzuki coupling, etc., appropriate palladium catalysts and ligands need to be selected to promote the binding of 4-hydroxyphenyl and iodotyrosine.
Fourth, the separation and purification of the product is crucial after the reaction is completed. The organic phase and the aqueous phase can be separated by extraction with an organic solvent such as ethyl acetate. After column chromatography, the appropriate silica gel column and eluent, such as the mixture of petroleum ether and ethyl acetate, can be selected according to the difference between the product and the polarity to achieve the purpose of separation, and pure O- (4-hydroxyphenyl) -3,5-diiodotyrosine can be obtained.
What is the market outlook for O- (4-hydroxyphenyl) -3,5-diiodotyrosine?
O- (4-hydroxyphenyl) -3,5-diiodotyrosine, an organic compound, has attracted much attention in the fields of medicine and chemical industry. Looking at its market prospects, there are many things to be said.
First of all, in the field of medicine, this substance is closely related to the synthesis of thyroxine. Thyroxine plays a key role in many physiological processes such as human metabolism, growth and development. And O- (4-hydroxyphenyl) -3,5-diiodotyrosine is an intermediate for thyroxine biosynthesis. With the in-depth research on thyroid-related diseases, such as hyperthyroidism and hypothyroidism, the clinical demand for thyroxine and its precursors may increase. As an important intermediate, this compound may gain more application opportunities in the preparation of thyroxine drugs, and the market demand may rise accordingly.
In the chemical industry, due to its special chemical structure, it can be used as a key raw material for organic synthesis. It can participate in the synthesis of many polymer materials and dyes with special properties. With the continuous advancement of the research and development of new materials in the chemical industry, the demand for compounds with unique structures is also increasing. O- (4-hydroxyphenyl) -3,5-diiodotyrosine may emerge in the chemical synthesis route due to its own structural advantages, contributing to the diversified development of chemical products and expanding its share in the chemical market.
However, its market development also faces challenges. The complexity of the synthesis process may result in high production costs, limiting its large-scale application. And the market awareness and understanding of this compound also need to be further improved to promote the release of its market demand. But overall, with the advancement of science and technology and the in-depth research in related fields, the market prospect of O- (4-hydroxyphenyl) -3,5-diiodotyrosine is quite promising, and it is expected to be more widely used and developed in the fields of medicine and chemical industry.