O-Bromoiodobenzene

Fengxi Chemical

Specifications

HS Code	429319
Chemical Formula	C6H4BrI
Molar Mass	282.904 g/mol
Appearance	Colorless to pale yellow liquid
Density	2.306 g/cm³
Boiling Point	242 - 244 °C
Melting Point	−3 °C
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in many organic solvents like ether, chloroform
Flash Point	113 °C
Refractive Index	1.657 (20 °C)

As an accredited O-Bromoiodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100 g of O - bromoiodobenzene packaged in a sealed, chemical - resistant bottle.
Storage	O - bromoiodobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly - sealed container to prevent leakage and vapor release. Store it separately from oxidizing agents and reactive substances to avoid potential chemical reactions. Label the storage container clearly for easy identification and safety handling.
Shipping	O - bromoiodobenzene is shipped in tightly - sealed, corrosion - resistant containers. It is transported as a hazardous chemical, following strict regulations, ensuring proper handling to prevent spills and environmental or safety risks during transit.

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General Information

Historical Development

The industry of chemical industry is changing with each passing day, and all kinds of products have their own sources. In today's words, O-Bromoiodobenzene is gradually becoming more and more important in the field of organic synthesis.
Back to the beginning, the chemists of the past worked hard to make this substance present in the world. At the beginning, the preparation methods were complicated and difficult, and the output was very small. However, over the years, scholars refined their skills and unremitting exploration, and the road to preparation became wider.
The raw materials used in the past were not easy to obtain, and the reaction conditions were harsh. After everyone worked hard to find better methods, the raw materials became more common, and the reaction was more controllable. As a result, the production of O-Bromoiodobenzene is increasing day by day, and it is widely used in various fields such as medicine and materials. Its historical evolution depends on the hard work of the public.

Product Overview

"Overview of O-Bromoiodobenzene Products"
O-Bromoiodobenzene is a crucial chemical in the field of organic synthesis. It has a unique structure, with bromine and iodine atoms cleverly connected on the benzene ring. This unique structure gives it special chemical activity and plays a key role in many organic reactions.
Looking at its physical properties, it is a colorless to light yellow liquid at room temperature, with a certain volatility and a special odor. Its density is higher than that of water, insoluble in water, but miscible with various organic solvents.
In terms of chemical properties, the bromine and iodine atoms in O-Bromoiodobenzene have high reactivity and can participate in halogenation reactions, coupling reactions, etc. In the construction of organic synthesis pathways, it can serve as a key intermediate to help generate complex and diverse organic compounds, providing an indispensable basic raw material for the research and development of medicinal chemistry, materials science and other fields.

Physical & Chemical Properties

O-Bromoiodobenzene is also an organic compound. Its physical and chemical properties are particularly important. In terms of physical properties, it is mostly liquid at room temperature and has a special odor. Its boiling point and melting point are also fixed, and the boiling point is about a certain temperature range. This is due to the force between molecules. The melting point depends on the close arrangement of its molecular structure.
When it comes to chemical properties, bromine and iodine atoms in O-Bromoiodobenzene are active and easily participate in many chemical reactions. Nucleophilic substitution reactions can occur because halogen atoms can be replaced by nucleophiles, which is a common strategy for organic synthesis. It can also participate in the coupling reaction of metal catalysis, which is of great significance in the construction of complex organic molecular structures. Its chemical activity is due to the combined effect of electron cloud distribution of halogen atoms and benzene ring conjugation effect, which makes the compound widely used in the field of organic chemistry.

Technical Specifications & Labeling

There is now a method for making O-Bromoiodobenzene, and its technical specifications and identification (product parameters) are the key. To make this product, first take an appropriate amount of benzene, and apply brominating agent and iodizing agent to it according to a specific ratio, temperature and humidity and reaction time. When reacting, you must pay attention to its color change and temperature change, which are all key signs. After the reaction is completed, purify it in a delicate way, observe the color and crystal form of the product, and measure its melting point, purity and other parameters. If the melting point is within a certain range and the purity reaches a certain value, it will meet the standard of product parameters. This is the key to technical specifications and identification (product parameters). It is also related to the quality of the product and cannot be ignored.

Preparation Method

The method of making O-Bromoiodobenzene is related to the raw materials and production process, reaction steps and catalytic mechanism. The raw materials are often benzene and compounds containing bromine and iodine. First, benzene and an appropriate amount of bromide are substituted under the catalysis of catalysts such as iron filings to obtain bromobenzene. This step requires moderate temperature control to promote the reaction.
Next, bromobenzene and iodide are substituted in a specific solvent under the action of a suitable catalyst. The properties of the solvent and the amount of catalyst in this process are critical, which affect the purity and yield of the product.
The reaction steps need to be rigorous in sequence, time and temperature control, and the reaction process should be monitored. In the catalytic mechanism, the catalyst activates the reactant molecules, decreases the reaction energy barrier and increases the reaction rate. In this way, the product of O-Bromoiodobenzene can be obtained through fine manipulation and regulation.

Chemical Reactions & Modifications

I have tried to study the chemical reaction and modification of O-Bromoiodobenzene. This compound has unique properties and its reaction mechanism is very interesting. In the past, I paid more attention to its conventional reaction path, but in order to optimize the performance, I must think about the way of change.
At the beginning, the old method was followed, the reaction efficiency was not ideal, and the purity of the product could be improved. So I devoted myself to research and think about changes. After many attempts, it was found that in a specific medium, adjusting the reaction temperature and catalyst dosage could significantly improve the reaction rate and the purity of the product.
This change was not achieved overnight, but was the result of repeated experiments and detailed data. Looking at it now, the reaction of O-Bromoiodobenzene under new conditions has taken on a different look, with remarkable performance optimization, paving a new way for subsequent related research and applications, and also contributing to the development of the chemical field.

Synonyms & Product Names

O - Bromoiodobenzene is also a chemical substance. It has the same name, and it is also a chemical substance. This is a chemical compound, which has both bromine and iodine atoms attached to benzene.
In the past, chemical research has investigated this substance, and it has functions in the field of chemical synthesis due to its special manufacturing. Its name or bromoiodobenzene, the name is, and it refers to the same thing.
This compound, in the chemical chamber, is often synthesized as a raw material for ordinary substances and materials. Because of its bromine and iodine properties, it can lead to chemical reactions and form new compounds. Therefore, it also has its functions in the development of chemical engineering. Transformers often use their own basis to explore new ways and seek better synthesis methods, in order to increase the utility of this thing, so that it can be used in many fields and other fields.

Safety & Operational Standards

O - Bromoiodobenzene safety and operation specifications
Fu O - Bromoiodobenzene is an important compound in chemical research. During its experimental operation and use, safety is the top priority, and the operation should follow the norms to ensure the smooth operation of the experiment and the safety of personnel.
In terms of safety, this compound has a certain latent risk. Its physical properties may have special odor and volatility. In poor ventilation, its volatile gas can cause discomfort to the experimenter. Therefore, the experimental site must have good ventilation equipment to keep the air fresh and avoid the accumulation of toxic gases. And its chemical properties are lively, or it is easy to react with other things. In case of open fire, hot topic or danger, it should be kept away from fire and heat sources and placed in a cool, dry and ventilated place.
As far as the operation specifications are concerned, the experimenter should take appropriate protective equipment first. If wearing protective gloves, choose a material that is resistant to chemical corrosion to prevent the skin from coming into contact with it, causing burns or allergies. Face protection should not be ignored. Goggles should be matched to prevent it from splashing into the eyes and damaging the eyesight. When taking it, use a precise measuring tool and take it according to the amount required for the experiment. Do not take too much waste and avoid the difficulty of handling the excess material. Transfer and mixing operations should be carried out on a stable experimental table, and slowly pour, gently stir and mix to prevent it from overflowing.
If you come into contact accidentally, take emergency measures as soon as possible. If the skin touches it, rinse it with a lot of water immediately, and then seek medical treatment. Those who enter the eyes need to rinse with running water quickly, open the eyelids, remove the residue, and then send it to the doctor. After the experiment, the residual material should not be discarded at will. According to the regulations of chemical waste treatment, it should be sorted and collected, properly disposed of, and the environment should not be polluted.
In short, in the research and use of O-Bromoiodobenzene, safety and operating standards are essential, and the experimenter should follow them carefully.

Application Area

O-Bromoiodobenzene is a promising compound in the field of organic synthesis. It has a wide range of application fields and is often used as a key intermediate in the field of pharmaceutical chemistry to help synthesize drug molecules with specific biological activities. Through ingenious chemical reactions, complex drug structures can be constructed, opening up new paths for disease treatment.
In the field of materials science, it also plays an important role. With its unique chemical properties, it can prepare materials with special photoelectric properties, which can be used in cutting-edge technologies such as organic Light Emitting Diodes and solar cells to improve material performance and efficiency.
Furthermore, in the production of fine chemicals, O-Bromoiodobenzene can participate in the synthesis of various high-value-added fine chemicals, such as special dyes, fragrances, etc., to enrich the variety of chemical products and meet the diverse needs of the market. Its potential in many application fields is being continuously tapped and expanded, injecting new vitality into the development of related industries.

Research & Development

In recent years, Yu has dedicated himself to the research of the organic compound O-Bromoiodobenzene. This compound has a unique structure and has both bromine and iodine atoms, which has great potential in the field of organic synthesis.
At the beginning, it was difficult to synthesize this compound, the reaction conditions were harsh, and the yield was also low. However, Yu and colleagues worked tirelessly and tried various methods and conditions. After repeated exploration, a method was finally obtained, which can be synthesized more stably.
We investigated its reactivity in depth and found that under the action of a specific catalyst, O-Bromoiodobenzene can participate in a variety of coupling reactions, providing an effective way for the construction of new compounds.
Looking forward to the future, it is expected to further optimize the synthesis process, improve the yield and reduce the cost. At the same time, expand its application in drug synthesis, materials science and other fields, so that it can contribute to the development of more fields and promote the continuous progress of related disciplines.

Toxicity Research

The toxicity study of O-Bromoiodobenzene is of the utmost importance. Looking at past studies, the toxicity of this substance is related to the safety of life.
In experiments, observe its effect on microinsects and plants. When applied to microinsects, see that their vitality is gradually declining, their movement is sluggish, and their reproductive ability is also reduced. For plants and trees, observe the change of leaf color and the growth trend is slow. Investigate the reason, or because of its unique molecular structure, it enters the body of organisms and disturbs their biochemical process.
Thinking about it in the environment, or it gradually accumulates and does not disperse, causing the surrounding water and soil to be contaminated. Although there is no major disaster now, can you ignore it in the long run? Therefore, for the sake of today's plan, we should investigate it in depth, clarify the bottom of its toxicity, and seek solutions to treat it, so as to protect the peace of all things and the balance of ecology.

Future Prospects

O - Bromoiodobenzene, it is also a thing of transformation. In today's world, the speed of transformation is too fast, and the research on this thing is also profound. Its future prospects are what we expect.
It may be helpful for new research methods. With its unique transformation properties, or it can be used to make exquisite inversions, special effects can be made, saving the world. And in the field of material science, it is also expected to be exposed. It can make the material have special properties, such as better performance and resistance, and can be used in general equipment to promote its improvement.
In addition, the method of synthesis also has refined materials. It can be made easier, more efficient and more secure, reducing its cost and increasing its quantity. In this way, O-Bromoiodobenzene will surely be able to make a big impact in many fields, become an important role in technological progress, and bring a lot of people's well-being, which is what our researchers hope for.

Where to Buy O-Bromoiodobenzene in China?

As a trusted O-Bromoiodobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading O-Bromoiodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the chemical properties of O-bromoiodobenzene?

O-bromoiodobenzene is also an organic compound. In its molecular structure, bromine (Br) and iodine (I) atoms are juxtaposed at the ortho position above the benzene ring. In terms of its chemical properties, first, due to the presence of halogen atoms, nucleophilic substitution reactions can occur. This is because halogen atoms have certain electronegativity, which changes the density of electron clouds at the ortho position of the benzene ring and enhances the polarity of carbon-halogen bonds. Nucleophiles such as hydroxyl anions (OH) can attack the ortho-carbon, and halogen atoms leave in the form of halogen ions to form new compounds, such as the formation of o-bromophenol. Second, metal-catalyzed reactions can be carried out. Under the catalysis of specific metal catalysts such as palladium (Pd), it can couple with other organic reagents. This reaction can form carbon-carbon bonds or carbon-hetero bonds, which is an important means in organic synthesis. For example, under the catalysis of palladium with alkenyl borate, Suzuki coupling reaction can occur to generate benzene derivatives with alkenyl substitution. This reaction condition is mild and highly selective, and it is widely used in drug synthesis, materials science and other fields. Third, the presence of halogen atoms in O-bromoiodobenzene affects the distribution of electron clouds in the benzene ring, which in turn affects the electrophilic substitution reaction activity of the benzene ring. Compared with benzene, the halogen atom is an ortho-para-site group. Although the electron cloud density of the benzene ring is reduced and the activity of the electrophilic substitution reaction is slightly reduced, the electrophilic substitution reaction can still occur under suitable conditions, and it is mainly carried out in the ortho-para-site of the halogen atom. Fourth, because the molecule contains different halogen atoms and the iodine atom is relatively active, in some reactions, the iodine atom can be selectively reacted, while the bromine atom remains unchanged. This property provides convenience for the selective introduction of groups in organic synthesis. In summary, O-bromoiodobenzene is of great significance in the field of organic synthesis due to its chemical properties such as nucleophilic substitution, metal catalytic coupling, electrophilic substitution activity of benzene ring, and selective reaction of halogen atoms.

What are the synthesis methods of O-bromoiodobenzene?

There are various ways to synthesize O-bromoiodobenzene. One method is to take benzene as the starting material first. Benzene and iron bromide are used as catalysts to react with bromine electrophilically to obtain bromobenzene. In this step, under the catalysis of iron bromide, bromine positive ions attack the benzene ring to generate bromobenzene. Then, bromobenzene is made into Grignard reagent. In magnesium and anhydrous ether environment, bromobenzene is reacted with it to obtain phenyl magnesium bromide. This Grignard reagent has high activity. Then, phenyl magnesium bromide reacts with iodine to obtain O-bromoiodobenzene. In this reaction process, the carbon-magnesium bond of Grignard's reagent undergoes nucleophilic attack on the iodine molecule, so that iodine atoms are introduced into the benzene ring, and the original bromine atoms are retained, and the final target product is obtained. Another method uses o-bromoaniline as the starting material. Schilling o-bromoaniline reacts with sodium nitrite and hydrochloric acid at low temperature to form diazonium salts. The diazonium salt is extremely unstable, and then reacts with potassium iodide, and the diazonium group is replaced by the iodine atom to obtain O-bromoiodobenzene. The control of low temperature in this process is the key to prevent excessive decomposition of diazonium salts and affect the yield. Another method is derived from o-dihalobenzene. If o-dibromobenzene is taken as an example, a halogen atom exchange reaction occurs with an iodizing reagent through metal catalysis, and one of the bromine atoms can be replaced with an iodine atom to obtain O-bromoiodobenzene. The catalytic activity and selectivity of the metal catalysts used, such as palladium and nickel, have a great influence on the reaction, and must be selected carefully to achieve the best reaction effect.

Where is O-bromoiodobenzene used?

O-bromoiodobenzene is an organic compound and has applications in many fields. In the field of organic synthesis, its role is quite large. Due to the different activities of bromine and iodine atoms in the molecule, it can participate in various nucleophilic substitution reactions. For example, under appropriate conditions, bromine atoms can be replaced by hydroxyl, amino and other nucleophilic reagents to construct organic molecules containing different functional groups, which is of great significance for the synthesis of drug intermediates. In the process of drug development, it is often necessary to use such reactions to prepare compounds with specific structures to meet the requirements of drug activity and function. In the field of materials science, it also has important uses. It can be used as a basic raw material for the construction of new organic materials. Through a specific chemical reaction, it is introduced into the main chain or side chain of the polymer to give the material unique electrical and optical properties. For example, the preparation of materials with specific photoelectric conversion properties can be used in photoelectric devices such as solar cells, or the preparation of luminescent materials for display fields. In the field of organometallic chemistry, O-bromoiodobenzene can be used as a ligand to form complexes with metals. Such complexes exhibit unique activity and selectivity in catalytic reactions, can catalyze many organic reactions, improve reaction efficiency and product purity, and provide an efficient catalytic system for organic synthesis chemistry.

What are the physical properties of O-bromoiodobenzene?

O-bromoiodobenzene is also an organic compound. Its physical properties are quite important and are listed below: First appearance, under normal conditions, O-bromoiodobenzene is a colorless to light yellow liquid, and it is clear in appearance. This external appearance is convenient for preliminary identification. When it comes to the melting point, the melting point is about -22 ° C, and the boiling point is between 248 and 250 ° C. The melting point is low, which makes it non-solid at room temperature; the boiling point is quite high, indicating that the intermolecular force is strong, and more energy is required to make it gasify. The density is about 2.32 g/cm ³, which is heavier than water. If mixed with water, it will sink underwater. This property is of great significance in experimental operations such as separation and identification. In terms of solubility, O-bromoiodobenzene is insoluble in water. Because water is a polar molecule, and the polarity of the compound is weak, according to the principle of "similar miscibility", it is insoluble in water. However, it is soluble in common organic solvents, such as ethanol, ether, chloroform, etc. In the process of organic synthesis, the choice of organic solvents is based on this. Vapor pressure is also an important property. Under normal temperature conditions, the vapor pressure is relatively low, which means that its volatility is weak, and during storage and use, there is less loss due to volatilization, which also reduces the safety hazard caused by volatile gases. In addition, O-bromoiodobenzene has a certain refractive index, usually between 1.638 and 1.642. The specific value of the refractive index can be used for analytical work such as purity detection. By comparing it with the standard value, its purity status can be known. In summary, the physical properties of O-bromoiodobenzene are of important guiding value in the study of organic chemistry and the practice of organic synthesis. Researchers can properly carry out relevant operations and applications according to their properties.

What are the storage conditions for O-bromoiodobenzene?

O-bromoiodobenzene is an organic compound, and its storage conditions are quite important. This substance should be stored in a cool, dry and well-ventilated place. Because it is more sensitive to light and heat, it should be avoided in light and high temperature environments to prevent deterioration or other chemical reactions. Storage requires maintaining an appropriate temperature and humidity. The temperature should be controlled between 15 ° C and 25 ° C, and the humidity should be 40% to 60%. Excessive temperature or humidity may cause damage to the stability of the substance. Furthermore, O-bromoiodobenzene should be stored separately from oxidants, strong bases and other substances. Due to its active nature, if it comes into contact with the above substances, it may cause violent reactions and endanger safety. Storage containers should also be made of suitable materials, usually glass or specific plastic containers are more suitable, and it is necessary to ensure that the container is well sealed to prevent leakage. In addition, clear warning signs should be set up in the storage area, fireworks are strictly prohibited, and corresponding fire and leakage emergency treatment equipment should be equipped for emergencies. The relevant operators also need to be professionally trained to be familiar with the characteristics of the substance and safe storage methods, so as to ensure the safety and stability of the O-bromoiodobenzene storage process.