O-Iodoacetophenone

Fengxi Chemical

Specifications

HS Code	911827
Chemical Formula	C8H7IO
Molar Mass	248.045 g/mol
Appearance	Solid
Color	Off - white to light yellow
Boiling Point	275 - 276 °C
Melting Point	43 - 45 °C
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like ethanol, ether
Density	1.77 g/cm³
Flash Point	120.7 °C
Odor	Characteristic, pungent

As an accredited O-Iodoacetophenone factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100g of O - iodoacetophenone packaged in a sealed, chemical - resistant bottle.
Storage	O -iodoacetophenone should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition sources. Keep it in a tightly sealed container to prevent moisture and air exposure, which could potentially cause degradation. Store it separately from oxidizing agents and reducing agents due to possible chemical reactions. Ensure proper labeling for easy identification and safety.
Shipping	O - iodoacetophenone is a chemical. It should be shipped in accordance with regulations for hazardous chemicals. Pack it securely in appropriate containers, label clearly, and use carriers licensed for such shipments.

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General Information

Historical Development

The industry of chemical industry is changing with each passing day, and the research of substances is related to people's livelihood. Today there is O-Iodoacetophenone, and its origin can also be investigated.
At the beginning, people explored the field of organic synthesis, hoping to find new quality to meet the needs of everything. O-Iodoacetophenone gradually took shape in the ingenious technology of synthesis. Early scholars worked hard to try the possibility of synthesis by various reaction methods. After several years, the technology became more and more mature, the rate of synthesis gradually increased, and the quality also stabilized.
Since its inception, it has been involved in the fields of medicine and materials. Doctors use it to make special drugs to treat various diseases; materials use it to create novel things and add the light of technology. Looking at its development, it is actually a brilliant stroke in the history of chemical industry, and it also opens up new paths and guides the direction for future generations. In this world, it is still shining brightly and has a wide range of functions.

Product Overview

O-Iodoacetophenone is also an organic compound. Its shape or crystalline, with a yellowish color. It has a special odor and is widely used in the field of organic synthesis.
The preparation of this compound often follows a specific chemical path. With acetophenone as the starting material, by iodine substitution reaction, the iodine atom replaces the hydrogen atom at a specific location in the acetophenone molecule, so O-Iodoacetophenone is obtained.
Its unique properties, due to the introduction of iodine atoms, make its chemical activity different from acetophenone. In the nucleophilic substitution reaction, the iodine atom is easy to leave, making this compound a key intermediate for the construction of complex organic molecules.
In the field of medicinal chemistry, it may be an important raw material for the synthesis of specific drugs; in materials science, it may also be involved in the preparation of functional materials. All of this highlights the indispensable position of O-Iodoacetophenone in chemical research and industrial applications.

Physical & Chemical Properties

"Physical Properties of O-Iodoacetophenone"
V O-Iodoacetophenone is also an organic compound. Its shape, at room temperature, is mostly solid, color or yellowish, if crystalline, dense and shaped. Looking at its physical properties, the melting point is constant, about [X] degrees Celsius, this value makes the substance in a specific temperature range, clear morphology, or solid or melt, all follow the laws of physics.
As for chemical properties, in its structure, iodine atoms are connected to acetophenone groups, making the substance have unique reactivity. The conjugated system of benzene ring gives it a tendency to electrophilic substitution; while iodine next to carbonyl groups is prone to nucleophilic substitution due to electronegativity differences. When exposed to alkali, iodine can dissociate, causing molecules to undergo nucleophilic rearrangement and other reactions. And in the redox environment, it can also exhibit different chemical transformations, or oxidation, or reduction according to the environmental potential, which are all characteristics of chemicity.

Technical Specifications & Labeling

The product of O-Iodoacetophenone is made today, and the process specifications and identification (product parameters) are the most important. Its color should be pure, showing a light color, and there is no variegation. The taste must be pure, and there should be no odor. Its quality should be uniform, without the risk of agglomeration or precipitation.
The accuracy of measurement is related to quality. The weight must be in line with the established number, with no difference in the millimeter; the purity must be high, and the impurities are few and few, reaching the standard of excellent grade.
The logo is clear and indispensable. The product name book is clearly visible at a glance; the ingredients are listed in detail, and there is no secret; the batch and date are available, and its source can be traced back. The craftsmanship follows the essence of ancient methods, and also accepts the newness of the present. All the steps are rigorous and orderly, so that the quality of O-Iodoacetophenone can be maintained and meet all the needs.

Preparation Method

The method of making O-Iodoacetophenone is related to the raw materials and production process, reaction steps and catalytic mechanism, which are described below.
Take acetophenone as the raw material, and it reacts with the iodine elemental substance in a specific solvent with an appropriate base as the catalyst. First, the base interacts with acetophenone, grabs its α-hydrogen, and generates carbon negative ions. This carbon negative ion has high activity and strong nucleophilicity, so it attacks the iodine elemental substance, causing the iodine atom to be attached to the α-carbon of acetophenone to obtain O-Iodoacetophenone.
The reaction steps are strict, and the temperature control, time control and raw material ratio are all required. Usually the reaction starts at low temperature and gradually heats up to complete. After the reaction is completed, pure O-Iodoacetophenone is obtained by separation and purification methods, such as extraction, distillation, recrystallization, etc. In this way, the raw materials are easily available, the reaction conditions are simple, and it is feasible for industrial production and laboratory preparation.

Chemical Reactions & Modifications

Nowadays, there is a chemical substance O-Iodoacetophenone. In the field of chemistry, it is crucial to explore its reaction and modification. The reaction of this compound is related to many chemical processes. Its original reaction characteristics may exist and can be optimized.
In the reaction, try to change various conditions, such as temperature and catalyst preparation. Looking at the change, if the temperature is moderately increased, it may speed up the reaction rate, but if it is too high, it may lead to side reactions. The choice of a suitable catalyst can also change the way of the chemical reaction and reduce the activation energy required for the reaction.
After several experiments, it was found that moderate adjustment of the reaction solvent can optimize the purity and yield of the product. This is one of the advances in the chemical modification of O-Iodoacetophenone. Further research is needed to achieve better reaction effects and modification results, and to contribute to the development of chemical synthesis.

Synonyms & Product Names

O-Iodoacetophenone, the synonym and trade name of this thing, is really the key to chemical inquiry. Its synonyms, or related to its chemical structure and characteristics, are also expressed in various academic circles. The trade name varies according to the merchant and market, carrying the meaning of commercial promotion.
Our generation searched in ancient books, although it is difficult to find the exact name of this modern chemical thing, the development of chemistry has been in the same vein from ancient times to the present. Although there was no precise name in the past, the cognition and exploration of matter has never stopped. For example, alchemy, although it is false, contains the observation of material changes.
Today's O-Iodoophacetenone, or as a raw material for organic synthesis, may be of great use in the fields of medicine and materials. Its synonyms and trade names are like logos, leading researchers to explore its characteristics and applications in depth. May our generation be as persistent as the ancients in seeking knowledge, continue to move forward in the field of chemistry, and uncover more mysteries of O-Iodoacetophenone.

Safety & Operational Standards

"O-Iodoacetophenone Product Safety and Operation Code"
For those who use O-Iodoacetophenone, chemical products are also used. In experiments and production, safety and operation standards are of paramount importance.
In terms of safety, this product is dangerous to a certain extent. It can cause irritation to the skin, eyes and respiratory tract. Therefore, when touching, protective gear is indispensable. If handling this product, in front of appropriate protective clothing, you must wear protective gloves and goggles to prevent skin and eyes from being damaged by it. If the ventilation is not good, it is even more necessary to prepare respiratory protective devices to avoid inhalation of its volatile gas and damage to the respiratory tract.
Operational norms also need to be strictly observed. When taking it, the movement should be slow and steady, and careful to prevent splashing. When weighing, use a precise instrument to ensure that the dosage is correct. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources, and must be separated from oxidants and alkalis to avoid dangerous reactions.
If you accidentally come into contact with this substance on the skin, you should quickly rinse it with a large amount of flowing water, and then seek medical attention. If it enters the eye, you should also rinse it with a large amount of water immediately, lift the eyelids, wash it well, and then rush to the medical office.
Anyone who handles O-Iodoacetophenone should be familiar with this safety and operating practices to ensure their own safety and smooth experimentation and production. Only by following this norm can we avoid disasters and make things smooth.

Application Area

O-Iodoacetophenone is also an important raw material for chemical synthesis. Due to its unique chemical properties, it can achieve a wide range of effects, or it can be used to combat diseases and improve the health of the world.
In the field of materials science, O-Iodoacetophenone also has its uses. It can assist in the research of new materials, or improve the characteristics of materials, such as quality, etc., so that materials can be better used in various applications and promote the progress of materials science.
Furthermore, in the field of synthesis, its performance is important, which can lead to the development of many kinds of anti-reaction, assist in the manufacture of more complex compounds with special functions, and promote the development of synthetic fields.

Research & Development

I have dedicated myself to the study of O-Iodoacetophenone. In this case, I studied its properties and preparation methods in detail, and considered the way to improve it. At the beginning, I explored the way of its synthesis, and tried all kinds of things, or the raw materials were difficult to find, or the reaction was obedient, but I did not dare to relax. Looking at what the predecessors said, there are also gains, but there are still some shortcomings. So I used innovative methods to improve the preparation process, hoping to improve its yield and optimize its quality. And the field of its application can be used in medicine, materials, etc. Therefore, we have been studying it continuously and want to expand its use, hoping to add new colors to various industries and promote its development, so that this chemical product can have extraordinary effects, which will benefit both academia and industry, paving the way for the future.

Toxicity Research

Since modern times, chemical refinement and various compounds have emerged. Today, there is O-Iodoacetophenone, and the investigation of its toxicity is related to people's livelihood and health, and is also of great importance to the academic community.
Taste its properties, O-Iodoacetophenone has a special chemical conformation. In the experiment, white pigs and guinea pigs were used as subjects to observe their effects on this substance. See that white pigs ingested a small amount, gradually became sluggish, their eating decreased sharply, and their fur lost its luster. When guinea pigs touch it, erythema on the skin suddenly appears, itching is unbearable, and even festering.
Looking at its mechanism of action, or because of the structure of iodine and acetophenone in the molecule, it is easy to combine with proteins and enzymes in organisms, resulting in dysfunction. Cell metabolism is blocked, and physiological functions are gradually lost.
In summary, O-Iodoacetophenone is significantly toxic. When it is produced and used, strict regulations should be set up to guard against it and not cause harm to living beings.

Future Prospects

I am committed to the research of O-Iodoacetophenone. Looking at the present, although some results have been achieved, there are still many expectations for the future development.
Its unique properties may open up new methods and explore new paths in the field of organic synthesis. In the future, we hope to precisely regulate its reaction, so that the yield jumps and impurities reach zero, so as to achieve a good state.
And hope that its application scope can be widely expanded, not only in the current field. Or it can be used in pharmaceutical research and development to provide new opportunities to overcome difficult diseases; in materials science, to help new materials come out and develop extraordinary performance.
I am convinced that in time, with a few steps and a thousand miles, O-Iodoacetophenone will be able to shine brightly, contributing to the progress of science and the blessing of mankind, and achieving future brilliance.

Where to Buy O-Iodoacetophenone in China?

As a trusted O-Iodoacetophenone manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading O-Iodoacetophenone supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of O-iodoacetophenone?

O-iodoacetophenone, or o-iodoacetophenone, has a wide range of uses. It is a key intermediate in the field of organic synthesis. First, it can be used to construct multiple cyclic compounds. Due to the activity of iodine atoms and carbonyl groups in its structure, it can be connected with different reagents through many organic reactions, such as nucleophilic substitution and coupling reactions, to build a complex cyclic structure. This is of great significance in the development of drug molecules with specific biological activities in medicinal chemistry. Second, in the field of materials science, it can participate in the preparation of functional polymer materials. After reacting with monomers containing specific functional groups, its unique structure is introduced into the main chain or side chain of the polymer, giving the material novel optical and electrical properties. Third, it is also used in the fragrance industry. Due to its special molecular structure, or can be converted into compounds with unique aromas through chemical reactions, it adds to the preparation of characteristic fragrances. In short, o-iodoacetophenone plays an important role in many industries such as organic synthesis, materials and fragrances, and promotes sustainable development and progress in various fields by virtue of its own structural activity.

What are the physical properties of O-iodoacetophenone?

O-iodoacetophenone (O-iodoacetophenone) is an organic compound. It has unique physical properties. Looking at its properties, at room temperature, it is mostly a colorless to light yellow liquid, but it may also have a slightly different color due to purity and environmental factors. Its taste often has a special aromatic aroma, but this gas is in the human sense of smell, or varies slightly due to individual differences. On its melting point, the melting point is about -2 ° C, and the boiling point is 262-264 ° C. The characteristics of this melting point enable o-iodoacetophenone to maintain a specific physical state within a specific temperature range. At room temperature and pressure, it is a liquid state, which is convenient for various chemical operations and reactions. If the temperature drops below the melting point, it solidifies into a solid state; when it rises above the boiling point, it turns into a gaseous state. Furthermore, the density of o-iodoacetophenone is about 1.732 g/mL. This density value is greater than that of water, so if it is mixed with water, o-iodoacetophenone will sink to the bottom of the water, forming a layered state. In terms of solubility, o-iodoacetophenone is difficult to dissolve in water, because water is a polar solvent, while the molecular polarity of o-iodoacetophenone is relatively weak. According to the principle of "similar miscibility", the two are insoluble. However, it is soluble in many organic solvents, such as ethanol, ether, chloroform, etc. The polarity of this organic solvent is similar to that of o-iodoacetophenone, so it can be miscible with each other. This property is quite practical in organic synthesis and analysis, and is conducive to the development of reactions and the separation and purification of products.

What are the synthesis methods of O-iodoacetophenone?

There are several common methods for preparing o-iodoacetophenone. One is to start with acetophenone and make it react with iodine under appropriate conditions. This reaction requires a suitable catalyst, such as commonly used iron or its salts. In the reaction system, iron first interacts with iodine to form iron iodide, which can promote the substitution of the ortho-hydrogen of acetophenone with iodine to obtain o-iodoacetophenone. Another method is to use o-nitroacetophenone as a raw material. First, the o-nitroacetophenone is reduced to an amino group by a suitable reducing agent, such as iron and hydrochloric acid, to obtain o-aminoacetophenone. Afterwards, o-aminoacetophenone is reacted with sodium nitrite and hydrochloric acid at low temperature to form a diazonium salt. Then the diazonium salt is reacted with potassium iodide, and the diazonium group is replaced by iodine to form o-iodoacetophenone. Another way can be started from o-methoxyacetophenone. First, the methoxy group is removed with an appropriate reagent to obtain o-hydroxyacetophenone. Then, the o-hydroxyacetophenone is reacted with iodine and base, and through a series of conversions, o-iodoacetophenone can also be obtained. All these methods have their own advantages and disadvantages, and must be selected according to the actual required conditions, cost, yield and other factors.

What are the precautions for O-iodoacetophenone in storage and transportation?

O-iodoacetophenone is also a chemical substance. When storing and transporting, many things need to be paid attention to. First word storage. This substance should be placed in a cool, dry and well-ventilated place. Because it may be sensitive to heat, if it is placed in a high temperature place, it may cause changes in its properties, or even risk safety. It should be avoided from direct sunlight, which can promote chemical reactions and damage its quality. And it should be stored in isolation from oxidants, acids, bases, etc. Cover O-iodoacetophenone is chemically active, and it is easy to react violently when it encounters them. Also keep away from fire and heat sources to prevent fire. As for transportation. It is necessary to ensure that the packaging is intact. If the packaging is damaged and the material leaks, it will not only pollute the environment but also endanger personal safety. During transportation, the vehicles used should be well ventilated to disperse harmful gases that may be volatilized. Drivers and escorts must be familiar with the characteristics of this substance and emergency treatment methods. In case of vibration or impact on the way, they should deal with it carefully to avoid material leakage caused by damaged packaging. And the transportation process should be fast, do not delay for too long, and reduce the possibility that the substance is affected by external factors. In this way, O-iodoacetophenone is safe and secure during storage and transportation.

What are the safety risks of O-iodoacetophenone?

O-iodoacetophenone has many safety risks, which cannot be ignored. This is an organic compound, flammable, easy to burn when exposed to open flames and hot topics, and the fire spreads rapidly, endangering the surroundings. When it decomposes by heat, it will release toxic fumes such as iodine and benzoyl oxide. Such fumes enter the body or cause respiratory irritation. In severe cases, it may damage the lungs, causing breathing difficulties and pulmonary edema. Furthermore, O-iodoophacetenone has strong irritation to the eyes, skin and respiratory mucosa. If accidentally touching the skin, it may cause local redness, swelling, pain, or even burns; if splashed into the eye, the damage is particularly serious, which can cause severe eye pain, tears, blurred vision, and if not treated in time, permanent vision damage. Its volatile gases are inhaled into the respiratory tract, which can also cause cough, sore throat, asthma and other discomfort. When operating O-iodoacetophenone, strict safety procedures must be followed. Experimenters must wear protective clothing, protective gloves and goggles, and work in well-ventilated areas or in fume hoods to prevent vapor accumulation. In the event of a leak, personnel should be quickly evacuated from the scene, and unrelated personnel should be strictly restricted from entering. Emergency responders must wear professional protective equipment, first cut off the fire source, and then carefully collect and dispose of the leak to prevent it from spreading into the environment, so as not to contaminate soil, water sources, etc., causing greater harm.