P Chloroiodobenzene
Iodobenzene

P-Chloroiodobenzene

Fengxi Chemical

    Specifications

    HS Code

    462181

    Chemical Formula C6H4ClI
    Molecular Weight 238.45
    Appearance White to off - white solid
    Melting Point 39 - 42 °C
    Boiling Point 238 - 240 °C
    Density 1.984 g/cm³
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like benzene, toluene
    Flash Point 104 °C
    Cas Number 637 - 87 - 6
    Odor Faint, characteristic odor

    As an accredited P-Chloroiodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of P - chloroiodobenzene packaged in a sealed, chemical - resistant bottle.
    Storage P - chloroiodobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames as it is potentially flammable. Keep it in a tightly closed container to prevent vapors from escaping. Store it separately from oxidizing agents and incompatible substances to avoid chemical reactions. Label the storage clearly for easy identification and safety.
    Shipping P - chloroiodobenzene is shipped in tightly - sealed, corrosion - resistant containers. Due to its chemical nature, it's transported following strict hazardous materials regulations, ensuring safe handling during transit.
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    P-Chloroiodobenzene
    General Information
    Historical Development
    P-Chloroiodobenzene is also an organic compound. Its historical development can be traced back to the past. Chemists first entered the field of organic synthesis and explored the preparation of various halogenated aromatics. At that time, for such benzene-based compounds containing chlorine and iodine, the synthesis method was still pioneering.
    In the early days, chemists mostly started with basic halogenation reactions and tried to introduce chlorine and iodine atoms on the benzene ring. However, the reaction conditions are harsh and the yield is not ideal. With the improvement of chemical technology, new catalysts and reaction paths have emerged. Taking the coupling reaction catalyzed by metals as an example, the efficiency and selectivity of P-Chloroiodobenzene synthesis have been greatly improved.
    This compound is increasingly used in the field of organic synthesis. It can be used as an intermediate and participates in the construction of many complex organic molecules. With the advance of science and technology, its synthesis methods have been continuously optimized, contributing to the development of organic chemistry, and making contributions to materials science, medicinal chemistry, and many other aspects. The future development is also full of promising signs.
    Product Overview
    P-Chloroiodobenzene is also an organic compound. In its molecular structure, above the benzene ring, there is one chlorine atom and one iodine atom each.
    The color state of this compound is usually a colorless to light yellow crystal or liquid at room temperature, with a special odor. Its melting point and boiling point are fixed. The melting point is about [specific melting point value], and the boiling point is about [specific boiling point value].
    In terms of its chemical properties, the conjugated system of benzene ring endows it with unique reactivity. The presence of chlorine and iodine atoms makes the compound participate in many nucleophilic substitution and electrophilic substitution reactions. Due to the difference in electronegativity between chlorine and iodine, the reaction check point and activity are also different.
    In the field of organic synthesis, P-Chloroiodobenzene has a wide range of uses. It is often a key intermediate for the construction of complex organic molecules. It can introduce other functional groups through various reaction paths to prepare compounds required in the fields of medicine, pesticides, materials, etc.
    There are several common methods for preparing P-Chloroiodobenzene. Or from benzene derivatives, through halogenation reaction, precise control of conditions, so that chlorine and iodine atoms are introduced in an orderly manner; or through transition metal catalyzed coupling reactions and other strategies.
    Physical & Chemical Properties
    P-Chloroiodobenzene is also an organic compound. Its physical and chemical properties are related to many aspects.
    In terms of physical properties, at room temperature, this substance may be in a solid state, with a specific color and smell. Its melting point and boiling point have fixed numbers, which are crucial for the separation and purification of substances. The melting point is the temperature at which a substance changes from a solid state to a liquid state; the boiling point is the temperature at which the liquid state changes to a gas state.
    In terms of chemical properties, the presence of chlorine and iodine atoms in P-Chloroiodobenzene gives it unique reactivity. Chlorine and iodine atoms can participate in many substitution reactions, interact with nucleophiles, or generate new compounds. In the field of organic synthesis, it is often an important intermediate. By virtue of its own reaction characteristics, it helps to build complex organic molecular structures and has important uses in the pharmaceutical, materials and other industries.
    Technical Specifications & Labeling
    P-Chloroiodobenzene is an organic compound. To prepare this compound, the process specifications and standards (product parameters) are very important. Its preparation requires a rigorous chemical process. It can usually be achieved by halogenation reaction, with benzene as the starting material, chlorine atoms are introduced through chlorination reaction, and then iodine atoms are added through iodization reaction.
    In terms of process specifications, the reaction temperature, reaction time, and the proportion of reactants need to be precisely controlled. The chlorination reaction temperature should be maintained at XX ° C, and the reaction time is about X hours; the iodization reaction temperature should be controlled at XX ° C, and the reaction time is about X hours. The ratio of reactants, benzene, chlorine gas, and iodine should be X: X: X.
    The product parameters cannot be ignored. The purity of P-Chloroiodobenzene must reach more than 98%, the appearance should be a colorless to slightly yellow liquid, the density is about X g/cm ³, and the boiling point is about XX ° C. Strictly follow this process specification and standard (product parameters) to produce high-quality P-Chloroiodobenzene products.
    Preparation Method
    There is a method for making P-Chloroiodobenzene. The raw materials are chlorobenzene and iodide. First, mix chlorobenzene with a specific iodide and put it into the reactor. Control its temperature and adjust its pressure to make the two respond. In the reaction step, stir slowly at the beginning to make the raw materials mix well, then gradually heat up to a suitable temperature, and the temperature should not be high or low, causing the reaction to be chaotic. When the time comes, observe the phenomenon, wait for the signs of color change and gas exit, and know that the reaction is going on.
    In the preparation process, the catalyst is also crucial. Choose the appropriate catalyst and add it to the kettle to promote the reaction speed and yield. This catalyst can reduce the energy barrier of the reaction and make the molecules easy to move and respond. And the catalytic mechanism is wonderful, with its activity check point, the raw material molecules are attracted to form a transition state and a fast-growing product. In this way, through fine control of raw materials, strict compliance with reaction steps, and good use of catalytic mechanisms, P-Chloroiodobenzene can be obtained for various uses.
    Chemical Reactions & Modifications
    The beauty of chemistry lies in reaction and change. The chemical change of P-Chloroiodobenzene is really an interesting topic.
    The reaction of P-Chloroiodobenzene often follows its structural characteristics. The position of chlorine and iodine affects its activity. When encountering nucleophiles, iodine often responds first because of its good departure. However, if the conditions change, chlorine also participates in the reaction, which is due to environmental factors that change the activity of the two.
    As for variability, temperature and solvent are both key. High temperature can promote the reaction speed, but it may also cause side reactions to occur. Different solvent polarities also make the reaction paths different. For example, in polar solvents, ionic reactions are easy to occur; in non-polar solvents, free radical reactions may prevail.
    Therefore, to study the chemistry of P-Chloroiodobenzene, it is necessary to observe the reaction conditions in detail to understand the law of reaction and change, in order to obtain its delicacy, which can be used in the chemical industry, medicine and other industries to create benefits to the world.
    Synonyms & Product Names
    There is now a chemical product called P-Chloroiodobenzene. The same trade name for this chemical product is also noted by us.
    P-Chloroiodobenzene, or chloroiodobenzene. In the field of chemistry, this name is often used to refer to this product. However, in the context of business, there may also be different names. The trade name may depend on the origin, purpose, etc.
    In my research, I often use this product under different names. There is, according to the purpose, in the text, polychloroiodobenzene; and the product produced by the family, or another name. This all needs to be studied to understand. In the process of chemical research and application, we can accurately grasp the various aspects of this object without confusion, so as to make the research and application effective.
    Safety & Operational Standards
    "P-Chloroiodobenzene Product Safety and Operation Specifications"
    P-Chloroiodobenzene is an important compound in chemical research. During its experimental operation and use, safety regulations are of paramount importance.
    First words storage method. This compound should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. Due to its certain chemical activity, improper storage environment, it is easy to cause deterioration or potential dangerous reactions. And must be stored separately from oxidizing agents, reducing agents, etc. to prevent interaction and accidental changes.
    As for the operation process, the experimenter must wear appropriate protective equipment. You need to wear a lab coat and protective gloves, which can resist the erosion of P-Chloroiodobenzene. Facial protection is also indispensable, and protective glasses and masks should be worn to prevent volatile gases or liquids from splashing into the eyes and mouth and damaging the body.
    When operating, the action should be steady and light to avoid violent oscillation to prevent it from spilling. If it spills accidentally, do not panic. When evacuating irrelevant personnel immediately, turn on ventilation equipment. When handling spills, follow relevant chemical specifications, collect them with appropriate adsorption materials, and then dispose of them properly. Do not discard them at will to avoid polluting the environment.
    Furthermore, during the experiment, the equipment used must first ensure that they are clean and intact. When using a specific reaction device, it is necessary to strictly follow the operating procedures, control the temperature, pressure and other conditions of the reaction, and beware of improper operation, which may cause the reaction to go out of control.
    In short, the safety and operation standards of P-Chloroiodobenzene should not be slack. Every step from storage to operation is related to the success or failure of the experiment and the safety of personnel. Only by strictly adhering to the standards can we move forward smoothly in the process of chemical research and avoid the risk of accidents.
    Application Area
    P-Chloroiodobenzene is also an organic compound. It has a wide range of uses in the chemical industry. In the field of material synthesis, it is often an important raw material. It can be combined with other reagents through specific chemical reactions to prepare various functional materials. If synthesizing polymers with special optical or electrical properties, P-Chloroiodobenzene can be a key starting material, giving the material unique properties, and has potential applications in optoelectronic devices, sensors, etc.
    In the field of pharmaceutical chemistry, it also has a place. The construction of some drug molecules depends on their participation in reactions. With precise chemical modification, compounds with specific pharmacological activities can be synthesized, which are expected to be developed into new drugs to treat various diseases.
    In addition, in the study of organic synthetic chemistry, P-Chloroiodobenzene, as a substrate, participates in many classical reactions, helps chemists to explore novel reaction paths and synthesis strategies, and contributes a lot to the development of organic chemistry. Its application field continues to expand and has broad prospects. It is a compound worthy of further study.
    Research & Development
    I dedicated myself to the research of P-Chloroiodobenzene. At the beginning, I explored the synthesis method of P-Chloroiodobenzene, searched the classics, visited various houses, and obtained one or two paths over time. However, the synthesis process was full of thorns, the reaction conditions were harsh, and the yield was unsatisfactory.
    So I thought about ways to improve it, studied it day and night, and tried it repeatedly. Adjust the ratio of reactants, change the catalytic agent, and observe the changes in temperature and pressure. After repeated attempts, I gradually made progress, and the yield was improved.
    And study the properties of this substance, explore its physical and chemical characteristics, and clarify its potential for application in various fields. Looking at it now, P-Chloroiodobenzene has considerable prospects in the fields of medicine and materials. I will be unremitting, hope to be able to tap its strengths again, promote its development, and add brilliance to the learning forest and help the industry.
    Toxicity Research
    An ancient discussion on the toxicity study of P-Chloroiodobenzene products
    The chemical substance under study today is called P-Chloroiodobenzene, and the study of its toxicity is quite important. The chemical properties of this substance may be invisible.
    Looking at the toxicological tests of the past, every nuance is related to the health of the people. The structure of P-Chloroiodobenzene, chlorine and iodine are combined in the benzene ring, its molecular state, or biochemical changes.
    After various experiments, observe its effect on organisms. In micro-organisms, it can disrupt its metabolic process; in higher organisms, or damage the ability of viscera. If it enters the skin, it may cause sensitivity and itching; if it enters the bloodline, it may disturb the travel of qi and blood.
    However, the study of toxicity cannot be achieved overnight. When the difference in dosage and the length of contact are carefully examined, and the various factors are integrated to clarify the harm. In today's world, the chemical industry is flourishing. Such research should not be ignored. We hope that detailed results will ensure everyone's safety and avoid the danger of poison.
    Future Prospects
    In the future, science and technology will thrive. In the field of chemical products, P-Chloroiodobenzene has a bright future.
    Today, although P-Chloroiodobenzene has emerged in many fields, its potential is still hidden. In the process of pharmaceutical research and development, it may be a key raw material for the creation of special new drugs, helping to overcome difficult diseases and enabling patients to regain health.
    Looking at materials science, over time, P-Chloroiodobenzene may trigger a tide of material innovation. With its unique chemical properties, it is expected to give birth to new functional materials, which can be used in high-end fields such as electronics and aerospace, adding extraordinary performance to equipment and equipment.
    Furthermore, as the concept of green chemistry is deeply rooted in the hearts of the people, the synthesis process of P-Chloroiodobenzene may usher in changes. Scientists will be committed to developing more environmentally friendly and efficient methods to reduce energy consumption, reduce pollution, and make its production and application fit the path of sustainable development.
    P-Chloroiodobenzene will shine like a star in the future, blooming in the sky of chemical products, creating extraordinary achievements for the well-being of mankind.
    Where to Buy P-Chloroiodobenzene in China?
    As a trusted P-Chloroiodobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading P-Chloroiodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the Chinese name of P-chloroiodobenzene?
    The name of an organic compound is p-chloroiodobenzene. In its molecular structure, there are two substituents on the benzene ring, one is a chlorine atom and the other is an iodine atom, and the two are in the opposite position.
    Looking at the name of this compound, the "right" is the relative position of the table two substituents, which is also in the opposite position of the benzene ring. "Chlorine" and "iodine" are the atomic types of the substituents connected. The word "benzene" indicates that its basic structure is a benzene ring.
    p-chloroiodobenzene is very useful in the field of organic synthesis. Because the chlorine and iodine atoms in the benzene ring have certain reactivity, other functional groups can be introduced through many chemical reactions, such as nucleophilic substitution reactions, to prepare a wide variety of organic compounds. In the field of medicinal chemistry, it is often used as an intermediate for the synthesis of drug molecules with specific biological activities; in the field of materials science, it can also be a key raw material for the synthesis of special organic materials. Therefore, although p-chloroiodobenzene is a small organic molecule, it plays an important role in many fields of organic chemistry.
    What is the chemical structure of P-chloroiodobenzene?
    P-chloroiodobenzene is also an organic compound. Its chemical structure is unique. The benzene ring is the base, and the upper two atoms are chlorine (Cl) and iodine (I). The benzene ring is a ring structure composed of six carbons, with a conjugated π bond, and its properties are stable.
    The chlorine atom and the iodine atom each live in the para-position of the benzene ring. The chlorine atom, one of the halogen elements, has a high electronegativity and has an electron-absorbing induction effect, which has an impact on the electron cloud distribution of the benzene ring. Although the iodine atom also belongs to the halogen group, its atomic radius is large and its polarization is strong.
    The two are in the para-position of the benzene ring and interact delicately. Due to the difference in electronegativity between chlorine and iodine This structure allows P-chloroiodobenzene to have the common properties of halogenated aromatics, such as electrophilic substitution reaction activity; and because of the characteristics of chlorine and iodine, it has unique reactivity. It is an important intermediate in organic synthesis chemistry and can construct complex organic molecules through various reactions.
    What are the main uses of P-chloroiodobenzene?
    P-chloroiodobenzene is one of the organic compounds and has important uses in the fields of organic synthesis, medicinal chemistry and materials science.
    In the field of organic synthesis, it is often a key building block for the construction of complex organic molecules. Due to the different reactivity of chlorine and iodine atoms, chemists can selectively cause them to react according to specific reaction conditions, so as to precisely construct the required carbon-carbon or carbon-heteroatom bonds. For example, in palladium-catalyzed cross-coupling reactions, chlorine atoms or iodine atoms can be coupled with different organometallic reagents to synthesize biphenyl derivatives with diverse structures, which is of great significance in the total synthesis of natural products and the development of new drugs.
    In the field of medicinal chemistry, P-chloroiodobenzene and its derivatives have shown potential biological activity. Some studies have shown that these compounds have inhibitory effects on specific cancer cell lines and are expected to be developed as new anti-cancer drugs. In addition, it has also attracted attention in the field of radiopharmaceuticals. Iodine atoms can be replaced by radioactive iodine isotopes for the preparation of radiolabeled drugs for the diagnosis and treatment of diseases, such as the preparation of radioactive tracers in positron emission tomography (PET) imaging technology.
    In the field of materials science, P-chloroiodobenzene can be used as a monomer for the synthesis of functional polymer materials. Through polymerization, it is introduced into the polymer skeleton, giving the material unique photoelectric properties. For example, the preparation of halogenated aryl-containing conjugated polymers, which exhibit good charge transport and luminescence properties in organic Light Emitting Diodes (OLEDs), organic solar cells and other optoelectronic devices, providing a new material choice for the development of high-performance optoelectronic devices.
    From this point of view, P-chloroiodobenzene has important uses in many fields, and with the continuous development of science and technology, its application prospects will be broader.
    What are the physical properties of P-chloroiodobenzene?
    P-chloroiodobenzene is also an organic compound. Its physical properties are as follows:
    Looking at it, this substance is a solid at room temperature, and its color is white to light yellow. Because of the orderly arrangement of molecular structures, the intermolecular forces at room temperature make the substance solid. And this color is caused by the transition of electrons within the molecule to absorb visible light of a specific wavelength and reflect the rest of the visible light.
    On the basis of its melting point, it is about 35-39 ° C. This is because when the temperature rises to a specific value, the thermal motion of the molecule intensifies, which is enough to overcome the lattice energy, the lattice structure disintegrates, and the substance changes from solid to liquid.
    As for the boiling point, it is about 236-238 ° C. When the temperature reaches the boiling point, the molecule gains enough energy to break free from the liquid phase and escape into the gas phase.
    In terms of solubility, P-chloroiodobenzene is insoluble in water. This is because there is a strong hydrogen bond between water molecules, while P-chloroiodobenzene is a non-polar molecule, and there is only a weak dispersion force between water molecules, which cannot overcome the hydrogen bond energy between water molecules, so it is insoluble. However, it is soluble in organic solvents, such as ether, chloroform, benzene, etc. Due to the principle of similar phase solubility, organic solvents are mostly non-polar or weakly polar, which is similar to the force between P-chloroiodobenzene molecules, and easy to mix with each other.
    Its density is greater than that of water. Due to the large relative atomic weight of chlorine and iodine atoms in the molecule, the mass per unit volume is increased, so the density is greater than that of water. This density characteristic makes it sink to the bottom when mixed with water.
    What are the preparation methods of P-chloroiodobenzene?
    There are several ways to prepare P-chloroiodobenzene, as well as organic compounds.
    One is the electrophilic substitution method. Using benzene as the starting material, the electrophilic substitution reaction occurs with chlorine first to obtain chlorobenzene. This reaction requires ferric chloride as a catalyst. At an appropriate temperature, benzene reacts with chlorine gas, and chlorine atoms replace hydrogen atoms on the benzene ring to obtain chlorobenzene. Then, chlorobenzene reacts with iodine under appropriate conditions. Iodine chloride (ICl) and other reagents can be used to replace hydrogen atoms at specific positions on the chlorobenzene ring under the catalysis of Lewis acid such as aluminum trichloride to obtain P-chloroiodobenzene. The chlorine atom on the Gein ring is an ortho-para-localization group, so that the reaction mainly generates para-substituted products.
    The second is the halogenated metal reagent method. The p-chlorophenyl magnesium halide (prepared by the reaction of p-chlorobrobenzene or p-chloroiodobenzene with magnesium in anhydrous ether and other solvents) is reacted with an iodine reagent. First, the p-chlorophenyl magnesium halide is prepared, which is a Grignard reagent with high activity. After that, it is reacted with iodine elemental or other suitable iodine-containing reagents at a low temperature and in an anhydrous and anaerobic environment to generate P-chloroiodobenzene. This process requires strict control of the reaction conditions to avoid side < Br >
    There is also a method using aryl diazonium salt as the intermediate. First, p-chlorobenzene diazonium salt is prepared from p-chloroaniline, and p-chlorobenzene diazonium salt is obtained by treating p-chloroaniline with sodium nitrite and hydrochloric acid at low temperature. Then, the p-chlorobenzene diazonium salt is reacted with iodine-containing reagents such as potassium iodide, and the diazonium group is replaced by iodine atoms to obtain P-chloroiodobenzene. This method requires low temperature operation to ensure the stability of the diazonium salt, and the control of the reaction conditions of each step is related to the