P Iodobenzeneboronic Acid
Iodobenzene

P-Iodobenzeneboronic Acid

Fengxi Chemical

    Specifications

    HS Code

    993300

    Chemical Formula C6H6BIO2
    Molar Mass 265.83 g/mol
    Appearance White to off - white solid
    Melting Point 245 - 249 °C
    Solubility In Water Slightly soluble
    Solubility In Organic Solvents Soluble in common organic solvents like DMSO, DMF
    Pka Around 8.8
    Stability Stable under normal conditions, but moisture - sensitive
    Hazard Class Irritant (may cause skin, eye, and respiratory irritation)
    Cas Number 61276 - 70 - 0

    As an accredited P-Iodobenzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 1 g of P - iodobenzeneboronic Acid packaged in a sealed, chemical - resistant vial.
    Storage P - iodobenzeneboronic acid should be stored in a cool, dry place, away from heat sources and direct sunlight. Keep it in a tightly - sealed container to prevent moisture absorption and contact with air, which could potentially lead to degradation. Store it separately from incompatible substances, such as strong oxidizing agents. This storage approach helps maintain its chemical integrity for reliable use in various applications.
    Shipping P - iodobenzeneboronic Acid is shipped in sealed, corrosion - resistant containers. It's carefully packed to prevent breakage. Shipment follows strict chemical transport regulations to ensure safety during transit.
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    P-Iodobenzeneboronic Acid
    General Information
    Historical Development
    In the past, the research on organoboron compounds was still in its infancy. At that time, many scholars worked hard to develop the method of organic synthesis.
    At a certain time, a wise man had insight into the potential of combining iodobenzene with boric acid derivatives. After repeated experiments and overcoming many difficulties, the method of preparing P-Iodobenzeneboronic Acid was finally obtained.
    Since then, with the evolution of science and technology, the preparation process has been continuously optimized. Its application in many fields such as medicine and materials has also gradually expanded. The understanding of its properties and applications has also deepened over time, from shallow to deep, driving this compound to shine in various fields.
    Product Overview
    "Overview of P-Iodobenzeneboronic Acid Products"
    P-Iodobenzeneboronic Acid is also a key reagent for organic synthesis. Its shape is usually white to off-white crystalline powder, and its properties are relatively stable. In many chemical reactions, especially in the formation of carbon-carbon bonds, such as the Suzuki-Miyaura coupling reaction, this product plays an indispensable role.
    Investigate its structure, on the benzene ring, the iodine atom is opposite to the boric acid group, and this unique structure gives it special chemical activity. With this structure, carbon-carbon bonds can be efficiently generated with halogenated aromatics, alkenyl halides, etc. under the action of suitable catalysts and bases, and then a variety of biologically active compounds, pharmaceutical intermediates and functional materials can be synthesized.
    The preparation method is mostly based on phenylboronic acid as the starting material and prepared by iodization reaction. This synthesis path is relatively mature, but the reaction conditions are highly controlled to obtain high-purity products to meet the needs of scientific research and industrial production.
    Physical & Chemical Properties
    P-Iodobenzeneboronic Acid, it is also an important agent in organic synthesis. Its physical properties are white crystalline at room temperature, and the stability is quite good. However, when it encounters strong acid or alkali or high temperature, it also changes. Its melting point is about 285-290 ° C. This specific melting point can be used to identify this substance. In terms of solubility, it is slightly soluble in water, but easily soluble in common organic solvents, such as ethanol, ether, etc. This property makes it in an organic reaction system, It can be well miscible with many reactants to promote the reaction. Its chemical activity and the characteristics of boron and iodine atoms endow it with unique reactivity. It often plays a key role in many organic synthesis reactions such as coupling reactions, providing a powerful tool for constructing complex organic molecular structures.
    Technical Specifications & Labeling
    "Technical Specifications and Labeling (Product Parameters) of P-Iodobenzeneboronic Acid"
    If P-Iodobenzeneboronic Acid, its technical specifications are the key. In terms of its purity, it needs to reach a very high standard, and the impurity content must be minimal to ensure the excellent quality of this product. Its appearance should show specific characteristics, or be in the shape of powder or crystal, and the color should also be pure and consistent.
    As for the logo, the product parameters should be clear. Such as molecular weight, molecular formula, etc. should be conclusive. On the package, the name and content of the product must be stated for identification. This is to ensure that P-Iodobenzeneboronic Acid can be accurately and effectively used when it is applied.
    Preparation Method
    P-Iodobenzeneboronic Acid, if you want to make it, when you know its raw materials and production process, reaction steps and catalytic mechanism.
    Raw materials, iodobenzene and borate esters are commonly used. First, iodobenzene and magnesium chips are mixed in anhydrous ether to obtain Grignard's reagent. This is a key step. It needs to eliminate water and oxygen. Gaige's reagent is active and decomposes in contact with water.
    Next, the prepared Grignard's reagent is mixed with borate ester, and the temperature is controlled and reacted in a timely manner. The reaction step should be slow to ensure that the raw materials are fully used.
    In the catalytic mechanism, transition metal catalysts are often used to help, such as palladium catalysts, which can reduce the activation energy of the reaction and promote the After the reaction is completed, pure P-Iodobenzeneboronic Acid can be obtained by separation and purification. During separation, extraction and distillation are selected according to the physical properties of the product and impurities. Purification is mostly by recrystallization to obtain refined products, which is a good method for preparation.
    Chemical Reactions & Modifications
    I am committed to the study of chemical substances, and recently focused on P-Iodobenzeneboronic Acid. Its chemical reaction and modification are of paramount importance.
    Looking at its reaction, in a specific medium, when it encounters a certain reagent, it often follows a predetermined path to form a specific product. If you want to achieve an ideal state, you need to consider various conditions in detail, such as temperature, pressure, and the proportion of reactants. If there is a slight difference, the results will be very different.
    As for modification, it aims to expand its application field. Or add functional groups to change its physicochemical properties, so that it can show unique effects in the fields of medicine and materials. After many attempts, some results have been obtained. Although the road ahead is still long, but I must uphold the heart of research, poor its mysteries, hope to achieve great success, for the advancement of chemistry, do my best.
    Synonyms & Product Names
    I have tried to study chemical products. Recently, I have paid a lot of attention to this thing in P-Iodobenzeneboronic Acid. Although its name is different from what is commonly heard, its function is quite obvious in the field of chemical industry.
    Looking at this product, there are also those who are called aliases. In the chemical industry, there are many people who have the same thing but different names, which is due to the different calling habits of all parties. P-Iodobenzeneboronic Acid, or because of its structure, nature, or because of the situation at the beginning of its discovery, has different names.
    In my research, I am well aware that the different names of the same substance, although referring to one thing, are easy to confuse. To explore this thing, we must carefully observe all the names and make it clear that they refer to the same thing, so as not to be wrong. This substance is often used as an essential agent in chemical synthesis and other things. Due to its characteristics, it can become a work that is difficult for others to do. Therefore, it is crucial to identify its synonyms and trade names in chemical research and cannot be ignored.
    Safety & Operational Standards
    About the safety and operation of P-Iodobenzeneboronic Acid products
    P-Iodobenzeneboronic Acid is a reagent commonly used in chemical research. In order to ensure the safety and effectiveness of the experiment, its safety and operation standards are extremely important.
    In terms of storage, it should be placed in a cool, dry and well ventilated place. This reagent is more sensitive to moisture. If the storage environment is humid, it is easy to cause it to deteriorate and affect the experimental effect. Keep away from fire and heat sources, because although it is not highly flammable, it may also cause danger due to heat and other factors under certain conditions. And it should be stored separately from oxidants and acids to avoid chemical reactions.
    When operating, be sure to take personal protection. Wear appropriate protective gloves to prevent the reagent from coming into contact with the skin, as it may cause irritation to the skin. At the same time, wear protective glasses to prevent the reagent from splashing into the eyes and causing damage to the eyes. If operated in a fume hood, it can effectively avoid inhaling the volatile aerosol of the reagent, because inhaling the reagent may have adverse effects on the respiratory tract.
    During use, use a clean and dry appliance to take the reagent to prevent impurities from mixing and affecting the purity of the reagent. Precisely control the dosage and measure it accurately according to the experimental requirements to avoid waste. If the reagent is accidentally spilled, correct handling measures should be taken immediately. When a small amount is spilled, it can be wiped with a clean rag and properly disposed of; when a large amount is spilled, personnel should be evacuated quickly, ventilation equipment should be started, and appropriate adsorption materials should be selected for cleaning according to the characteristics of reagents.
    Waste disposal should not be ignored. Relevant environmental regulations must be followed and cannot be discarded at will. Generally speaking, discarded P-Iodobenzeneboronic Acid should be handed over to a professional waste treatment agency for harmless treatment to protect the environment and human health.
    Only by strictly observing the above safety and operation norms can P-Iodobenzeneboronic Acid be used safely and efficiently in chemical research to promote the smooth development of research work.
    Application Area
    P-Iodobenzeneboronic Acid, it is also a treasure of chemistry. Its use is very useful in the field of synthesis. It can be used as the key to reverse the synthesis, so that the aryl groups can be interacted with each other, and it is also indispensable in the process of research. Helping new molecules, or the foundation of anti-cancer and anti-infection remedies. In the material science, special materials, such as light and light, have novel properties. It can be used, or it can be made for special use, so that crops can be protected from diseases and diseases. All of this is the importance of Acid in the field of multi-use, and it is a weapon of chemical research.
    Research & Development
    I P-Iodobenzeneboronic Acid for years. This compound is quite useful in the field of organic synthesis. It can participate in many reactions, such as the Suzuki reaction, forming bonds between aryl groups, and constructing diverse molecular structures. It has made great contributions to the research and development of medicine and materials.
    At the beginning, the preparation of this acid was complicated and the yield was also low. Various attempts were made to improve the process. After long-term research, the reaction conditions were optimized, and the suitable reagents and catalysts were selected. Finally, the yield was significantly improved and the quality was also excellent.
    Under the heading of research and development of its application. Hoping to create new drugs with better curative effect and less side effects in the synthesis of new drugs; in the field of materials, to help create materials with special properties, such as photoelectric materials, to meet the needs of scientific and technological development. In the future, hope to use this as a basis to open up more possibilities and promote related fields to move forward vigorously.
    Toxicity Research
    The industry of chemical industry is related to people's livelihood, but the study of poisons is also an important matter. Today, in terms of P-Iodobenzeneboronic Acid, the study of its toxicity should not be ignored.
    In the experimental environment, observe its response to various things, observe its effect on organisms. Or enter the micro body, observe the change of its cells, and observe the difference of its metabolism. See it or disturb the order of cells, disrupt the process of its biology.
    And explore its shadow in the environment, if the water flows, disperses in the soil, observe whether the surrounding organisms are harmed by it. Although this substance has its uses in chemical industry, the harm of toxicity should also be investigated in detail. It is necessary to understand its nature in order to make good use of it and avoid disasters. It is the responsibility of our researchers to protect the safety of the living and the tranquility of the environment.
    Future Prospects
    The chemical substance of today, known as P-Iodobenzeneboronic Acid, has extraordinary potential. Although it is used or not widely known today, I look to the future, this substance will definitely bloom in various fields.
    In the field of medicine, it may be the cornerstone of the creation of new drugs. With its unique structure, it can precisely interact with biomolecules to help overcome difficult diseases. In materials science, it is also expected to give birth to novel materials to meet the needs of high-tech.
    Although there may be thorns in the way forward, the road of scientific research is endless. I firmly believe that with time, it will be able to tap its potential and make great contributions to human well-being. The exhibition of the future, like the migration of Peng in Nanming, will skyrocket and be limitless.
    Where to Buy P-Iodobenzeneboronic Acid in China?
    As a trusted P-Iodobenzeneboronic Acid manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading P-Iodobenzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of P-iodobenzeneboronic Acid?
    P-iodobenzeneboronic acid (P-iodobenzeneboronic Acid) is an important reagent in organic synthesis. Its main use has a wide range of paths.
    First, it plays a key role in the Suzuki-Miyaura cross-coupling reaction. This reaction is an effective means of building carbon-carbon bonds. P-iodobenzeneboronic acid can be successfully coupled with halogenated aromatics, halogenated olefins, etc. in the presence of palladium catalysts and bases, thereby preparing a series of biphenyls and alkenylbenzene compounds with specific structures. Such compounds are of critical significance in the field of materials science, such as the creation of organic Light Emitting Diode (OLED) materials, which can endow materials with unique photoelectric properties. In the field of medicinal chemistry, they are also an important step in the synthesis of many biologically active drug molecules, through which the reaction can accurately construct the core skeleton of drug molecules.
    Second, p-iodophenylboronic acid can be used to prepare functionalized organoboron compounds. Organoboron compounds are widely used in organic synthesis chemistry and can be further transformed to form boron-containing heterocyclic compounds. These functionalized organoboron compounds can be used as unique catalysts or ligands in the field of catalysis, exhibiting unique catalytic activity and selectivity; in the surface modification of materials, they can endow materials with new characteristics, such as improving the hydrophilicity and biocompatibility of materials.
    Third, p-iodophenylboronic acid is also indispensable in the design and synthesis of some fluorescent probes. Due to the special electronic structure of boron atoms, compounds can have unique optical properties. By rationally designing the molecular structure and introducing the p-iodophenylboronic acid part, fluorescent probes with selective identification ability for specific ions and molecules can be prepared. These probes can be used in the field of biomedical testing to detect the content and distribution of specific substances in organisms, and help early diagnosis and treatment monitoring of diseases.
    What are the physical properties of P-iodobenzeneboronic Acid?
    P-iodobenzeneboronic acid (P-iodobenzeneboronic Acid) is an important reagent in organic synthesis. Its physical properties are as follows:
    The appearance is mostly white to off-white crystalline powder, which is easy to identify and handle. In many experimental operations and industrial production steps, this appearance characteristic can help to distinguish its purity and state.
    The melting point is between 275 and 280 ° C. This melting point range is clear, providing an accurate reference for practical applications. When heating p-iodobenzeneboronic acid, it is necessary to operate with caution near this temperature range to prevent excessive heating from causing its decomposition or other adverse reactions, which will affect the subsequent synthesis effect.
    In terms of solubility, it is slightly soluble in water. This means that in the water-based system, the degree of solubility of p-iodophenylboronic acid is limited. However, it is soluble in common organic solvents such as dichloromethane, ethanol, tetrahydrofuran, etc. This solubility characteristic makes it possible to select a suitable organic solvent to fully dissolve p-iodophenylboronic acid and participate in the reaction according to the reaction requirements and conditions. For example, in some homogeneous reaction environments, organic solvents that can dissolve p-iodophenylboronic acid can be selected to create suitable reaction conditions.
    Due to its unique physical properties, p-iodophenylboronic acid is widely used in the field of organic synthesis to construct carbon-carbon bonds, carbon-heteroatomic bonds and other reactions, and plays a key role in many fields such as medicinal chemistry and materials science.
    P-iodobenzeneboronic the chemical properties of Acid
    P-iodophenylboronic acid is an important reagent in the field of organic synthesis. It has many unique chemical properties.
    In terms of acidity, boric acid compounds are usually weakly acidic, and P-iodophenylboronic acid is no exception. Its acidity originates from the outer electronic structure of boron atoms. Boron atoms have empty orbitals and can accept lone pairs of electrons on hydroxyl oxygen atoms, which prompts hydrogen atoms in hydroxyl groups to dissociate more easily, but their acidity is weak.
    In nucleophilic substitution reactions, the iodine atom of P-iodophenylboronic acid can be used as a leaving group and replaced by nucleophilic reagents. This property is widely used in the construction of carbon-carbon bonds, carbon-heteroatomic bonds and other reactions. < Br >
    And its boric acid part can participate in many important reactions, such as the Suzuki-Miyaura coupling reaction. In this reaction, P-iodophenylboronic acid forms a carbon-carbon bond efficiently with halogenated aromatics or other electrophilic reagents under the action of palladium catalysts and bases, providing a key way for the synthesis of polyaryl compounds.
    In terms of stability, P-iodophenylboronic acid is generally relatively stable in a dry and cool environment, but when exposed to water or high temperature, reactions such as hydrolysis may occur, resulting in structural changes and affecting its chemical activity.
    In terms of solubility, it has a certain solubility in common organic solvents such as dichloromethane and tetrahydrofuran, which is conducive to its uniform dispersion and reaction in organic synthesis reaction systems.
    In short, P-iodophenylboronic acid plays a key role in the field of organic synthesis chemistry due to its chemical properties such as acidity, nucleophilic substitution activity, ability to participate in coupling reactions, specific stability and solubility, providing an effective means for the preparation of many complex organic compounds.
    What is the preparation method of P-iodobenzeneboronic Acid?
    The method of preparing p-iodophenylboronic acid can follow the following steps. First take p-iodobromobenzene, which is the starting material of the reaction. Place this in a clean reaction vessel, and use anhydrous ether as a solvent to create an anhydrous environment, because the subsequent reaction is extremely sensitive to water. Then, at a low temperature and protected by nitrogen, slowly add magnesium chips. During this process, magnesium and p-iodobrobenzene will react to form a Grignard reagent. The reaction principle is that magnesium atoms are inserted between carbon-halogen bonds to form a highly active carbon-magnesium bond.
    When the Grignard reagent is complete, then slowly drop the reaction solution into trimethyl borate. Trimethyl borate will undergo a nucleophilic substitution reaction with Grignard's reagent. The negatively charged carbon part in Grignard's reagent attacks the boron atoms in trimethyl borate, and then the reaction mixture is treated with a dilute acid solution through a hydrolysis step. When hydrolyzed, the structure of the orthoboronic ester is transformed into a boric acid structure, so that p-iodophenylboronic acid can be obtained.
    Another preparation method is to use p-iodoaniline as the starting material. Let p-iodoaniline react with sodium nitrite and dilute hydrochloric acid at low temperature to form a diazonium salt. This diazonium salt is extremely active and has poor stability. After that, the diazonium salt is reacted with boron-containing reagents such as sodium borohydride, and the diazonium group is replaced by the boron group. After appropriate post-treatment, such as extraction, washing, drying, column chromatography separation, etc., p-iodophenylboronic acid with high purity can also be obtained. These two methods have their own advantages and disadvantages. The former requires anhydrous and anaerobic conditions, and the operation is slightly complicated, but the yield is relatively considerable; the latter starting material is relatively easy to obtain, but the diazonation reaction needs to be strictly controlled to prevent the decomposition of diazonium salts.
    P-iodobenzeneboronic Acid in storage and transportation
    P-Iodophenylboronic acid, when storing and transporting, need to pay attention to many matters. Its nature or more active, easy to change in case of moisture. Therefore, when storing, be sure to choose a dry, cool and well-ventilated place, away from high temperature, humidity and direct sunlight. It should be sealed and stored to prevent moisture from invading and causing it to deteriorate.
    During transportation, also be cautious. Because it is a special chemical item, it must be properly packaged in accordance with relevant regulations. Packaging must be tight to prevent damage and leakage. During handling, handle it with care, do not allow violent vibration and collision, so as not to damage the package and cause danger. And the transportation environment should also be kept suitable, avoid high temperature and hot topics, and maintain relatively stable conditions. Furthermore, the transporter needs to understand its chemical properties and emergency treatment methods. If there is an accident, it can be handled quickly and properly to ensure the safety of personnel and the environment. In this way, P-iodophenylboronic acid can be safely stored and transported.