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What is the chemical structure of (r) -1- (5-fluoro-2-iodophenyl) ethan-1-ol?
The chemical structure of (r) -1 - (5-fluoro-2-iodophenyl) ethanol is one of the structures of organic compounds. In this compound, the ethanol group is the main structure, and the hydroxyl group of the ethanol is connected to a carbon, which is in turn connected to (5-fluoro-2-iodophenyl).
In (5-fluoro-2-iodophenyl), the benzene ring is the basic skeleton, and the upper fifth carbon atom is connected with a fluorine atom, and the second carbon atom is connected with an iodine atom. In this compound, the aromaticity of the benzene ring endows it with certain chemical stability and unique reactivity. The electron cloud distribution and spatial structure of the compound are greatly affected by the electronegativity and atomic radius difference between the fluorine atom and the iodine atom. The hydroxyl group of the
ethanol group has nucleophilicity and hydrogen bond formation ability, and can participate in many chemical reactions, such as esterification and substitution. The fluorine and iodine substituents on the benzene ring not only affect the electron cloud density of the benzene ring, but also affect the reactivity of the ethanol group connected to it. Overall, the chemical structure of (r) -1 - (5-fluoro-2-iodophenyl) ethanol makes it have unique application and research value in the fields of organic synthesis, medicinal chemistry, etc., because of its complex structure or diverse chemical reaction paths and biological activity expressions.
What are the physical properties of (r) -1- (5-fluoro-2-iodophenyl) ethan-1-ol?
(R) -1 - (5-fluoro-2-iodophenyl) ethanol, this is an organic compound. Its physical properties are unique and related to many properties of the substance.
Looking at its appearance, it is often a colorless to light yellow oily liquid. Under specific lighting and environments, it may have a slight color change, but the whole is mostly in this category. Although its smell is not rich and pungent, it has a unique organic compound smell, which is slightly fragrant, but not as sweet as a flower fragrance, but with a slight chemical charm.
When talking about the boiling point, in view of the interaction between fluorine and iodine atoms and ethanol groups in the molecular structure, the intermolecular force changes, and the boiling point is roughly within a certain range. The fluorine atom has strong electronegativity, which enhances the polarity of the molecule, and the iodine atom has a large mass, which increases the intermolecular dispersion force. Under the synthesis, the boiling point is higher than that of ordinary simple alcohols, which is roughly in a specific temperature range. This is slightly different due to different experimental conditions.
In terms of melting point, the degree of orderly arrangement of the molecules of the compound determines the melting point. The steric hindrance and electronic effect of fluorine and iodine atoms affect the tightness of molecular stacking. Usually, the melting point changes from solid to liquid at a certain temperature, and the solid-state time carrier arrangement is relatively regular. With the increase of temperature, the thermal motion of the molecules intensifies, and when it reaches the melting point, it turns into a liquid state.
Solubility is also a key physical property Because it contains hydroxyl groups and has a certain hydrophilicity, it can have a certain solubility in water. However, fluorine and iodine substituents increase molecular hydrophobicity, so the solubility is better in organic solvents such as dichloromethane and ether. This difference in solubility plays a significant role in chemical synthesis, separation and purification steps, and suitable solvents can be selected according to this characteristic to achieve experimental purposes.
What are the common synthesis methods of (r) -1- (5-fluoro-2-iodophenyl) ethan-1-ol?
To prepare (R) -1- (5-fluoro-2-iodophenyl) ethanol, there are several common synthesis methods as follows.
One is the reaction of halogenated aromatics with Grignard reagents. First, take 5-fluoro-2-iodobromobenzene, make it and magnesium chips in a suitable solvent such as anhydrous ether, under the protection of inert gas, co-heat to initiate the reaction, and prepare the corresponding Grignard reagent. Then, the Grignard reagent is slowly dropped into the ether solution of acetaldehyde, and the reaction temperature is controlled to make it fully react. After the reaction is completed, the reaction solution is carefully treated with dilute acid, and then the target product can be obtained through various steps such as extraction, drying, and distillation. In this process, Grignard's reagent has high activity and strict requirements on reaction conditions. It is necessary to ensure an anhydrous and anaerobic environment to avoid side reactions.
Second, palladium-catalyzed cross-coupling reaction can be used. The reaction is carried out by heating and stirring in an alkaline environment, such as an aqueous solution of potassium carbonate and an organic solvent mixed system, with 5-fluoro-2-iodophenylboronic acid and (R) -1-bromoethanol as raw materials, catalyzed by palladium catalysts such as tetra (triphenylphosphine) palladium, etc. This reaction has good selectivity and can effectively build carbon-carbon bonds. After the reaction, a pure target product can be obtained by separation and purification techniques, such as column chromatography. However, palladium catalysts are expensive and the reaction cost is high.
Third, 5-fluoro-2-iodoacetophenone is used as the starting material and prepared by reduction reaction. Reducers such as sodium borohydride can be selected, which are slowly added to an alcohol solution of 5-fluoro-2-iodoacetophenone and reacted at low temperature and stirred. The reduction ability of sodium borohydride is moderate, and the reaction is easy to control. After the reaction is completed, (R) -1 - (5-fluoro-2-iodophenyl) ethanol can also be obtained after acidification and separation. However, attention should be paid to controlling the degree of reaction during the reduction process to prevent excessive reduction and other conditions.
In what fields is (r) -1- (5-fluoro-2-iodophenyl) ethan-1-ol used?
(R) -1 - (5-fluoro-2-iodophenyl) ethanol, this compound has applications in many fields such as medicine, materials science and organic synthesis.
In the field of medicine, due to its special structure, or unique biological activity. Or can act as a key intermediate for the creation of new drugs. Taking the development of anti-tumor drugs as an example, researchers modify the structure of the compound to explore its interaction with specific targets in tumor cells, hoping to find new anti-cancer drugs with high efficiency and low toxicity.
In the field of materials science, it can be used as a raw material for the synthesis of functional materials. Because it contains special atoms such as fluorine and iodine, it may endow materials with unique electrical and optical properties. For example, when preparing organic optoelectronic materials, introducing this structure or improving the charge transfer efficiency and luminescence properties of the material will help the development of new display technologies and optoelectronic devices.
Organic synthesis category, as an important intermediate, can participate in many organic reactions. With its chiral structure, asymmetric synthesis can be achieved to obtain high-purity chiral compounds. For example, when constructing complex natural products or drug molecular frameworks, it is used for nucleophilic substitution, addition and other reactions to precisely construct the required carbon-carbon bonds and carbon-heteroatomic bonds, expanding the boundaries of organic synthesis chemistry and providing the possibility for the synthesis of a variety of novel organic molecules.
What is the market outlook for (r) -1- (5-fluoro-2-iodophenyl) ethan-1-ol?
Today there is (r) -1 - (5-fluoro-2-iodophenyl) ethanol, and its market prospects are as follows:
This substance has great potential in the field of organic synthesis. The structure of 5-fluoro-2-iodophenyl gives it unique reactivity. Fluorine atoms have high electronegativity, which can affect the distribution of molecular electron clouds and change the activity of reaction check points. Iodine atoms provide opportunities for the construction of carbon-carbon bonds and carbon-heteroatom bonds in many reactions such as coupling reactions. Therefore, in the synthesis of fine chemicals such as the creation of new drugs and functional materials, or as key intermediates.
In terms of drug development, organic compounds containing fluoride and iodine often have special physiological activities. Based on (r) -1 - (5-fluoro-2-iodophenyl) ethanol, drug molecules with high affinity and selectivity for specific disease targets can be derived. Nowadays, the pharmaceutical industry has a strong demand for novel structurally active compounds, so it is expected to gain a place in the drug synthesis raw material market.
In the field of materials science, fluorine-containing materials have many characteristics such as excellent chemical stability and low surface energy. The iodine-containing structure may affect the electrical and optical properties of materials. With this ethanol compound, new photoelectric materials, high-performance coating materials, etc. can be developed. With the advance of science and technology, the demand for unique performance materials in the material market is increasing, and there is a vast space for development in this field.
However, its marketing activities also have challenges. The synthesis process may need to be refined to reduce costs and increase productivity in order to better meet the large-scale needs of the market. And the market competition is fierce, and similar or alternative intermediates are also competing. Only by continuous innovation and optimizing performance and synthesis paths can we emerge in the market and seek long-term development.
