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What is the chemical structure of (r) 2- (5-chloro-4-iodopyridin-2-ylamino) propan-1-ol?
This is the problem of organic compounds. The chemical structure of (r) -2- (5-chloro-4-iodopyridine-2-ylamino) propane-1-ol can be determined according to its name.
According to its name, the main chain of this compound is propylene-1-ol, that is, the 1st position of propane is connected with a hydroxyl group (-OH). At the 2nd position, there is a substituent, which is an amino group (-NH2O), and the nitrogen atom of this amino group is connected with 5-chloro-4-iodopyridine-2-group. 5-Chloro-4-iodopyridine-2-yl, the pyridine ring is a six-membered nitrogen-containing heterocycle, the nitrogen atom occupies the 1st position, the 2nd position is connected to the above-mentioned amino nitrogen, the 4th position has an iodine atom (-I), and the 5th position has a chlorine atom (-Cl). In addition, (r) shows that this compound is chiral and has an r-type configuration.
In this way, the chemical structure of (r) 2- (5-chloro-4-iodopyridine-2-ylamino) propane-1-ol is clarified, and the main chain propane-1-ol 2 position is connected to a specific pyridyl amino substituent, and has an r-type chiral configuration.
What are the physical properties of (r) -2- (5-chloro-4-iodopyridin-2-ylamino) propan-1-ol
(R) -2 - (5-chloro-4-iodopyridine-2-ylamino) propane-1-ol has many physical properties. Its form may be white to off-white crystalline powder, which is caused by the orderly arrangement of molecular structure and stable interaction, resulting in such forms.
In terms of solubility, it may have a certain solubility in organic solvents such as methanol and ethanol. This is because the polar groups such as amino groups and hydroxyl groups contained in the compound can interact with the polar molecules of methanol and ethanol to form hydrogen bonds, etc., and then dissolve them. However, the solubility in water may be limited, because some parts of the pyridine ring and halogen atoms in the molecule are non-polar or weakly polar, which hinders their full interaction with water molecules. The melting point of
has been experimentally determined, or is in a certain temperature range. This is due to the intermolecular forces, such as hydrogen bonds, van der Waals forces, etc., which need to absorb a specific energy to break, causing the substance to change from a solid state to a liquid state, so there is a specific melting point range. The boiling point of
is also determined by factors such as the intermolecular forces and the relative molecular mass. The relative molecular mass is large, and there are various interactions between molecules, which requires high energy to make the molecules break free from each other, vaporize and escape, and thus have a corresponding boiling point. The density of
is closely related to the degree of molecular accumulation. Due to the characteristics of molecular structure, the atomic arrangement is established, and its mass per unit volume is relatively stable, so it has a specific density value.
Refractive index is also an important physical property of the substance, reflecting the refractive characteristics of light propagating in it, and is closely related to the electron cloud distribution and structure of the molecule.
What are the synthesis methods of (r) 2- (5-chloro-4-iodopyridin-2-ylamino) propan-1-ol
To prepare (R) -2 - (5-chloro-4-iodopyridine-2-ylamino) propane-1-ol, the following method can be used.
Take 5-chloro-4-iodopyridine-2-amine as the starting material, and the chlorine and iodine on the pyridine ring of this amine are positioned at specific positions and have reactivity. React it with (R) -propylene oxide properly protected. (R) -propylene oxide is chiral, its epoxy structure is very active, and it is vulnerable to attack by nucleophiles. The amino group of 5-chloro-4-iodopyridine-2-amine is a nucleophilic check point, which can attack the epoxy carbon of propylene oxide, make the epoxy ring open, and form an intermediate connecting the structure of pyridyl group and propanol.
This reaction requires the selection of suitable solvents, such as dichloromethane, N, N-dimethylformamide, etc., to facilitate the dissolution of raw materials and the reaction. It is also necessary to control the reaction temperature and time. Generally, it starts at low temperature and gradually heats up to make the reaction smooth and sufficient to avoid side reactions.
After the epoxy ring-opening reaction is completed, if there is a protective group, the deprotection step needs to be Depending on the type of protecting group used, select specific deprotection conditions. If it is protected by tert-butoxycarbonyl, it can be removed by acid hydrolysis; if it is protected by benzyl, it can be removed by catalytic hydrogenation. After deprotection, the product can be separated from the reaction mixture by separation and purification techniques, such as column chromatography, using silica gel as the stationary phase, and selecting a suitable eluent. Pure (R) -2 - (5-chloro-4-iodopyridine-2-ylamino) propane-1-ol can be obtained.
Another method is available. First, (R) -2-aminopropyl-1-ol can be reacted with appropriate protective reagents to protect the amino group to obtain the protected (R) -2-aminopropyl-1-ol. After reacting with 5-chloro-4-iodine pyridine, chlorine or iodine on the pyridine ring can be replaced by nucleophiles to form the precursor of the target product. Finally, the amino protective group is removed and the target product can be purified. This process also requires careful selection of protective reagents, reaction conditions and purification methods to achieve high yield and high purity.
What are the main uses of (r) 2- (5-chloro-4-iodopyridin-2-ylamino) propan-1-ol?
What is the main use of (R) -2 - (5-chloro-4-iodopyridine-2-ylamino) propane-1-ol? This is a question that has attracted much attention in the field of fine chemicals.
In the field of pharmaceutical research and development, (R) -2 - (5-chloro-4-iodopyridine-2-ylamino) propane-1-ol may have important effects. Because of its specific chemical structure, it can be used as a key intermediate for the synthesis of many specific drugs. Pyridine compounds are often biologically active. The introduction of chlorine and iodine atoms in this compound may be able to fine-tune their activity and pharmacological properties. Or it can participate in the synthesis of antibacterial drugs by interfering with specific metabolic pathways of bacteria to achieve antibacterial effect; or it can be used to develop anti-tumor drugs to inhibit the proliferation and spread of tumor cells by precisely acting on specific targets of tumor cells.
In the field of materials science, it may also have potential uses. Due to the presence of amino groups and alcohol hydroxyl groups in its structure, it may be used as a functionalizing agent to modify the surface of materials. For example, introducing it into the surface of polymeric materials may improve the hydrophilicity and biocompatibility of materials. In this way, the application of polymer materials in biomedicine, environmental engineering and other fields can be expanded, such as the preparation of better biodegradable materials to meet the current needs of environmental protection.
In addition, in the study of organic synthetic chemistry, this compound may be an important building block. With its unique structure, chemists can build more complex organic molecules, explore new chemical reaction paths and methods, promote the progress of organic synthetic chemistry, and lay the foundation for the creation of new materials and new drugs in the future.
What should be paid attention to when (r) 2- (5-chloro-4-iodopyridin-2-ylamino) propan-1-ol is stored and used?
(R) -2 - (5-chloro-4-iodopyridine-2-ylamino) propane-1-ol is a special chemical substance. When storing and using, many matters need to be paid attention to.
First words storage. This substance should be stored in a cool, dry and well-ventilated place. Because it may be sensitive to humidity and temperature, high temperature and humid environment can easily cause its properties to change, and even cause chemical reactions and damage its quality. Therefore, the warehouse temperature should be controlled within a certain range, and dehumidification equipment is required to keep it dry. At the same time, it should be stored separately from oxidants, acids, bases, etc., to prevent interaction. Because its chemical structure contains specific functional groups, in case of such substances or violent reactions, it will cause danger. The storage place should also be clearly marked, indicating the name of the substance, its nature and precautions, so that personnel can identify and protect.
Times and use. When using, be sure to be fully armed and wear appropriate protective equipment. Such as protective glasses, which can protect the eyes from accidental splashing of the substance; protective gloves can prevent skin contact, because it may be irritating and corrosive to the skin; protective clothing is also indispensable to fully protect the body. The operation should be carried out in the fume hood, which can effectively discharge the harmful gases that may be generated and avoid the inhalation of the operator. Before use, it is necessary to carefully check the relevant equipment and instruments to ensure that they are clean and functional, so as to prevent impurities or failures from affecting the use effect. During use, strictly follow the established operating procedures to precisely control the dosage and reaction conditions. Due to the reactivity of the substance or specific requirements, the conditions are slightly deviated, or the reaction results are poor, or it may bring safety hazards. After use, properly dispose of the remaining substances, and do not discard them at will. Recycle or dispose of them harmlessly in accordance with relevant regulations to avoid polluting the environment.
