What is the chemical structure of (r) -tert-butyl 3- (4-amino-3-iodo-1h-pyrazolo [3,4-d] pyrimidin-1-yl) piperidine-1-carboxylate

The chemical structure of (R) -tert-butyl 3- (4-amino-3-iodine-1H-pyrazolo [3,4-d] pyrimidine-1-yl) piperidine-1-carboxylate is a delicate structure in the field of organic chemistry.

Looking at its structure, this compound is cleverly spliced from several key parts. Tert-butyl, with its unique steric hindrance effect, stands proudly in the molecule like a fortress, affecting the spatial configuration and chemical activity of the whole molecule. Its structure is stable, and it also has a subtle impact on the electron cloud distribution of surrounding groups.

3- (4-amino-3-iodine-1H-pyrazolo [3,4-d] pyrimidine-1-yl) moiety, the pyrazolo [3,4-d] pyrimidine ring system constitutes the core skeleton of the molecule. The existence of the conjugate structure endows the molecule with specific electron delocalization characteristics, making it chemically stable and uniquely reactive. 4-Amino group, as the electron-supplying group, can enhance the electron cloud density of the ring system, significantly affecting its nucleophilicity and reactivity with other reagents; 3-iodine atom, due to the large volume and strong electron-absorbing properties of the iodine atom, not only changes the electron cloud distribution of the ring system, but also may act as a leaving group in specific reactions, introducing rich chemical reaction possibilities for the molecule.

Piperidine-1-carboxylate part, the piperidine ring exists in its chair or boat conformation, providing a flexible skeleton, which is crucial for the regulation of the overall conformation of the molecule. Carboxylic acid ester groups can participate in various chemical reactions such as hydrolysis and esterification, further expanding the chemical transformation path of the compound.

The various parts of this compound cooperate with each other to form a unique chemical structure, which may have important application potential in many fields such as medicinal chemistry and organic synthetic chemistry, or can be used as a lead compound to start the journey of new drug development, or act as a key intermediate in organic synthesis, resulting in a series of unique functional organic molecules.

What is the main use of (r) -tert-butyl 3- (4-amino-3-iodo-1h-pyrazolo [3,4-d] pyrimidin-1-yl) piperidine-1-carboxylate?

(R) -tert-butyl 3- (4-amino-3-iodine-1H-pyrazolo [3,4-d] pyrimidine-1-yl) piperidine-1-carboxylic acid ester, its use is quite critical. In the field of medicinal chemistry, it is often used as a key intermediate to synthesize compounds with specific biological activities. Or due to the unique molecular structure, in the process of developing new drugs, it can be chemically transformed to shape drug molecules that fit disease therapeutic targets.

In the eyes of drug developers, it is an important cornerstone for exploring new ways of disease treatment. By modifying its structure, a variety of compounds can be derived, and its effect on specific disease-related targets can be tested, hoping to find new drugs with good efficacy and small side effects.

In the field of organic synthesis, it is an important starting material for the construction of complex molecular structures. With its special structure, it can participate in a variety of organic reactions, such as nucleophilic substitution, cyclization, etc., helping chemists build complex and biologically active molecular structures, thus expanding the boundaries of organic synthesis chemistry and providing support for the development of drug creation, materials science and other fields.

What are the synthesis methods of (r) -tert-butyl 3- (4-amino-3-iodo-1h-pyrazolo [3,4-d] pyrimidin-1-yl) piperidine-1-carboxylate

The synthesis method of (r) -tert-butyl 3- (4-amino-3-iodine-1H-pyrazolo [3,4-d] pyrimidine-1-yl) piperidine-1-carboxylic acid esters is often studied in the field of organic synthesis. To prepare this substance, several paths can be followed.

First, it can be obtained by coupling reaction between intermediates containing pyrazolo [3,4-d] pyrimidine structure and reagents containing piperidine carboxylate structure. First, the core structure of pyrazolo [3,4-d] pyrimidine is constructed from suitable starting materials through a multi-step reaction, such as the introduction of iodine atoms through a specific halogenation reaction, and the addition of amino groups through a suitable amination reaction. This intermediate is then coupled with the protected piperidine-1-carboxylate derivative in the presence of a suitable catalyst, base and solvent. This process requires careful selection of reaction conditions, such as temperature, time and ratio of reactants, to increase the yield and purity of the product.

Second, starting from piperidine-1-carboxylate, the piperidine ring can be modified first, and suitable substituents can be introduced, and then the structure of pyrazolo [3,4-d] pyrimidine can be constructed by cyclization reaction. In this case, protection and deprotection strategies may be used to ensure the selectivity of the reaction and the smooth progress of each step of the reaction.

In the synthesis process, the separation and purification of the reaction product at each step is very critical, and means such as column chromatography and recrystallization are often used to obtain high-purity products. And spectral analysis such as NMR, MS and other techniques should be used to confirm the structure of the product.

What are the physicochemical properties of (r) -tert-butyl 3- (4-amino-3-iodo-1h-pyrazolo [3,4-d] pyrimidin-1-yl) piperidine-1-carboxylate

(R) -tert-butyl 3- (4-amino-3-iodine-1H-pyrazolo [3,4-d] pyrimidine-1-yl) piperidine-1-carboxylic acid ester, which is an organic compound. Its physical and chemical properties are quite important, related to its application in many fields.

First talk about the appearance and properties. Under normal circumstances, it may be a white to off-white solid powder with a fine texture. This form is easy to store and transport, and also has advantages in subsequent processing operations.

Melting point is one of the important physical properties. After experimental determination, its melting point may be in a specific temperature range, which is of great significance for identifying the compound and controlling its purity. Due to the different purity of the compound, the melting point may be slightly different.

In terms of solubility, in organic solvents, such as common methanol, ethanol, dichloromethane, etc., show a certain solubility. However, the solubility in water is poor. This characteristic determines its suitable solvent in different reaction systems and separation and purification steps. The appropriate selection of organic solvents can effectively improve the reaction efficiency and product purity.

Stability cannot be ignored. Under normal temperature and pressure and dry environment, the compound is relatively stable and has no obvious change in chemical properties. However, under extreme conditions such as high temperature, strong acid, and strong alkali, its structure may be damaged, triggering chemical reactions and causing chemical properties to change. In case of strong acid, ester group or hydrolysis reaction, the corresponding carboxylic acid and alcohol are formed; in case of high temperature, the chemical bonds or breaks in the molecule are rearranged.

Spectral properties are also critical. At a specific wave number in its infrared spectrum, there will be absorption peaks characterizing the vibration of different chemical bonds, which can help confirm the various chemical bonds contained in the molecule, such as the C = O bond vibration absorption peak of the ester group. Nuclear magnetic resonance spectroscopy can provide information on the chemical environment of different hydrogen and carbon atoms in the molecule, which can accurately analyze the molecular structure.

In summary, the physicochemical properties of (r) -tert-butyl 3- (4-amino-3-iodine-1H-pyrazolo [3,4-d] pyrimidine-1-yl) piperidine-1-carboxylic acid esters are diverse and complex, and their properties are interrelated, laying the foundation for their application in organic synthesis, drug discovery and other fields.

What are the applications of (r) -tert-butyl 3- (4-amino-3-iodo-1h-pyrazolo [3,4-d] pyrimidin-1-yl) piperidine-1-carboxylate in medicine?

(R) -tert-butyl 3- (4-amino-3-iodine-1H-pyrazolo [3,4-d] pyrimidine-1-yl) piperidine-1-carboxylate, this compound is used in the field of medicine and has a wide range of functions.

In the past, the techniques of medicine were all aimed at the healing of diseases and the health of the body. Today, this compound has emerged in the road of anti-cancer. Cancer is like a fierce enemy, eroding human health. And (R) -tert-butyl 3- (4-amino-3-iodine-1H-pyrazolo [3,4-d] pyrimidine-1-yl) piperidine-1-carboxylate can precisely target the key check point of cancer cells, just like a magic weapon, directly attacking Huanglong. It can block the proliferation signaling pathway of cancer cells, making cancer cells like rootless trees, difficult to continue to multiply, inhibit the growth of cancer, and add a sharp weapon to the fight against cancer.

Furthermore, in the field of immune regulation, it can also be used. The immune system of the human body is like a fortress, guarding the body. However, under many diseases, the immune system is out of balance. This compound can fine-tune the activity of immune cells, so that they can perform their duties and return to a balanced state. Or activate immune cells to enhance their resistance to pathogens; or inhibit overactive immune responses to prevent them from accidentally attacking their own tissues, which has great potential for the treatment of immune-related diseases.

It has also been found in the exploration of neurological diseases. Neurological diseases, such as epilepsy and Parkinson's disease, have plagued patients for a long time. ( R) -tert-butyl 3- (4-amino-3-iodine-1H-pyrazolo [3,4-d] pyrimidine-1-yl) piperidine-1-carboxylate can regulate the transmission of neurotransmitters, stabilize the electrical activity of nerve cells, or open up new paths for the treatment of nervous system diseases, leading doctors to explore better ways to solve patients' pain.