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What is the chemical structure of (s) -2- (3-iodophenyl) pyrrolidine?
(S) -2 - (3 -iodophenyl) pyrrolidine, its chemical structure is also. The structure of this compound is formed by connecting a pyrrolidine ring with an iodine-containing benzene ring. The pyrrolidine ring is a five-membered nitrogen-containing heterocyclic ring with saturated carbon-carbon and carbon-nitrogen bonds. In the second position of the pyrrolidine ring, there is a substituent group, namely 3-iodophenyl. This 3-iodophenyl group is a benzene ring replaced by an iodine atom at the third position. The benzene ring is a six-membered aromatic ring with a conjugated π electron system, which gives it special chemical properties. The iodine atom attached to the benzene ring has an impact on the electron cloud distribution and spatial structure of the molecule due to its electronegativity and atomic radius. The nitrogen atom on the pyrrolidine ring has a lone pair of electrons, which can participate in chemical reactions and affect the basicity of the molecule and the ability to interact with other molecules. The (s) -configuration indicates that the compound has a specific stereochemical structure. The spatial arrangement of atoms in the molecule is different from that of its enantiomers. This stereoconfiguration may have significant effects on many chemical reactions and biological activities. The structure of this compound, combined with the characteristics of the pyrrolidine ring, the iodine-containing benzene ring and the specific stereoconfiguration, jointly determines its unique chemical and physical properties.
What are the main uses of (s) -2- (3-iodophenyl) pyrrolidine?
(S) -2 - (3 -iodophenyl) pyrrolidine is one of the organic compounds and has important uses in many fields.
First, in the field of pharmaceutical chemistry, this compound may be a key intermediate. Due to its unique structure, it can participate in a variety of chemical reactions to construct drug molecules with specific pharmacological activities. For example, by modifying its structure, different functional groups can be introduced to adjust the interaction between drugs and biological targets, improve the efficacy of drugs, and reduce side effects. In the process of many new drug development, such intermediates are often indispensable materials, helping to create new drugs for the treatment of various diseases such as cardiovascular diseases and nervous system diseases.
Second, in the field of materials science, (S) -2- (3-iodophenyl) pyrrolidine can also be used. It can be used as a basic unit for building functional materials. After polymerization or compounding with other materials, it can endow materials with special physical and chemical properties. For example, it can improve the conductivity and optical properties of materials, which can be used in electronic devices, optical materials and other fields, such as the preparation of new Light Emitting Diode materials, sensor sensitive materials, etc.
Third, in the field of organic synthesis chemistry, it is an important synthetic building block. Chemists can use the strategy of organic synthesis and its structural properties to carry out the synthesis of various complex organic molecules. By ingeniously designing reaction paths and combining them with other organic reagents, the construction of carbon-carbon bonds and carbon-heteroatom bonds is realized, and the structural diversity of organic compounds is expanded, providing a rich material basis and method path for the development of organic synthetic chemistry.
What are the synthesis methods of (s) -2- (3-iodophenyl) pyrrolidine?
The synthesis of (S) -2- (3-iodophenyl) pyrrolidine is an important topic in organic synthetic chemistry. In the past, there were several common ways to synthesize this compound.
One is based on the derivatization reaction of nitrogen-containing heterocycles. A suitable parent pyrrolidine can be taken first, and its structure has been carefully designed with functional groups that can be further modified. 3-iodophenyl is introduced into the pyrrolidine ring by the nucleophilic substitution reaction of halogenated aromatics. During this process, careful selection of reaction conditions, such as the type and dosage of bases, and the polarity of solvents, all have significant effects on the reaction rate and selectivity. For example, the use of potassium carbonate as a base, in N, N-dimethylformamide (DMF) solvent, at appropriate temperatures, can effectively couple halogenated aromatics with pyrrolidine derivatives, and gradually build the structure of the target molecule.
Second, the cyclization reaction catalyzed by transition metals. Starting with a substrate containing alkenyl groups and aryl halides, under the action of transition metals (such as palladium, nickel, etc.) catalysts, pyrrolidine rings are formed through intramolecular cyclization, and 3-iodophenyl groups are introduced at the same time. This method depends on the activity of the catalyst and the structure of the ligand. Suitable ligands can improve the reaction activity and stereoselectivity. For example, the synthesis of (S) -2- (3-iodophenyl) pyrrolidine with high yield and good stereochemical control can be guided by complexing a phosphine ligand rich in electrons and suitable steric resistance with a palladium catalyst.
Third, the synthesis strategy induced by chiral auxiliaries. First, the chiral auxiliaries are connected to the reaction substrate, and the chiral product (S) -2- (3-iodophenyl) pyrrolidine is obtained through the removal of auxiliaries. The selection of chiral adjuvants and the design of subsequent removal steps in this strategy are quite demanding, and it is necessary to ensure that the adjuvants can effectively induce chirality and the removal process does not affect the structure and purity of the product.
What are the physical properties of (s) -2- (3-iodophenyl) pyrrolidine?
(S) 2- (3-iodophenyl) pyrrolidine is one of the organic compounds. Its physical properties are particularly important, and it is related to its performance in various chemical processes and practical applications.
Looking at its appearance, it is often colorless to light yellow liquid, which makes it easy to disperse and participate in reactions in many reaction systems. It has a specific boiling point, about [specific value] ℃, which is determined by intermolecular forces, such as van der Waals forces and hydrogen bonds. The characteristics of boiling point are a key consideration when separating and purifying this compound. It can be separated by distillation according to its boiling point difference.
Furthermore, the melting point is also an important physical property. The melting point is about [specific value] ° C. The melting point reflects the tightness and stability of the molecular lattice arrangement. The melting point of this compound determines the conditions for its transition between solid and liquid states, and is of great significance for the choice of storage and transportation conditions.
Solubility cannot be ignored. In organic solvents such as ethanol and dichloromethane, (S) 2- (3-iodophenyl) pyrrolidine exhibits good solubility due to the existence of suitable interactions between its molecular structure and organic solvent molecules, such as dipole-dipole interaction or dispersion force. However, in water, its solubility is relatively limited, due to the weak force between water molecules and the compound molecules, and the molecular polarity of the compound does not reach the degree of solubility with water.
In addition, the density is about [specific value] g/cm ³. This physical quantity is crucial for accurate measurement and configuration of the reaction system, and is related to the control of the proportion of reactants and the reaction process.
In summary, the physical properties of (S) 2- (3-iodophenyl) pyrrolidine, such as appearance, boiling point, melting point, solubility and density, are of indispensable importance in its chemical research, synthesis and practical application. It is a key basis for chemists to control its participation in various reactions and achieve specific functions.
What is the market outlook for (s) -2- (3-iodophenyl) pyrrolidine?
(S) -2 - (3 -iodophenyl) pyrrolidine is the market prospect of today, which is shared by the industry. This compound has great potential in the field of pharmaceutical research and development. At present, the wind of pharmaceutical innovation is booming, and there is a growing demand for organic molecules with unique structures and activities. (S) -2 - (3 -iodophenyl) pyrrolidine can be used as a key intermediate for the creation of new drugs due to its special configuration and phenyl cycloiodide structure.
In the field of synthetic chemistry, it is the cornerstone of building complex active molecules, through which chemists can develop novel synthetic pathways and generate a variety of drug candidates. Taking the development of anti-tumor drugs as an example, many research teams are exploring this as a starting material to build compounds that target specific tumor cell targets, hoping to find new drugs with outstanding efficacy and minimal side effects.
Furthermore, with the deepening of life science research, drug exploration in neurological diseases, cardiovascular diseases and other fields is also in the ascendant. (S) -2 - (3-iodophenyl) pyrrolidine may emerge in such research, because its structure or specific interaction with related disease targets paves the way for the creation of new drugs.
However, although the market prospect is good, it also faces challenges. The optimization of the synthesis process is related to cost and yield, and chemists need to make every effort to achieve high efficiency and green environment. And the road of drug development is long, and preclinical and clinical trials need to go through many tests before the drug based on this compound can be successfully launched and benefit patients.