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What is the chemical structure of (s) 2- (5-chloro-4-iodopyridin-2-ylamino) propan-1-ol?
The chemical structure of (s) -2- (5-chloro-4-iodopyridine-2-ylamino) propyl-1-ol is composed of three parts.
The first is the propyl-1-alcohol structure, which is the main chain. Propanol contains three carbon atoms, and the hydroxyl group is attached to the No. 1 carbon in a straight chain shape.
The second is the amino part, which is connected to the propanol No. 2 carbon. This amino group is derived from 5-chloro-4-iodopyridine-2-yl, in which the pyridine ring is a hexavalent nitrogen-containing heterocycle and has aromatic properties. The nitrogen atom occupies a specific position in the ring, giving the ring a unique electron cloud distribution and chemical activity.
Furthermore, the second position of the pyridine ring is connected to the amino group, the fifth position is connected to the chlorine atom, and the fourth position is connected to the iodine atom. Both chlorine and iodine are halogen elements, which have strong electronegativity and have a great impact on the electron cloud of the pyridine ring, which makes the whole compound unique in chemical properties.
Due to the existence of chiral carbon, this compound has a (s) configuration. Chiral carbon is connected to the carbon atoms of four different groups, giving the compound optical activity, which can rotate polarized light in a specific direction and angle.
Overall, the chemical structure of (s) -2- (5-chloro-4-iodopyridine-2-ylamino) propyl-1-ol fuses alcohol, amino group and halogenated pyridine group, and the interaction of each part determines its unique physical and chemical properties.
What are the physical properties of (s) 2- (5-chloro-4-iodopyridin-2-ylamino) propan-1-ol?
(S) -2 - (5-chloro-4-iodopyridine-2-ylamino) propane-1-ol, the physical properties of this substance are as follows:
Looking at its morphology, it may be a white to off-white solid powder under normal conditions. Due to the presence of aromatic rings and polar groups in the structure of these organic compounds, intermolecular forces prompt it to appear in this form. Its melting point, or due to intramolecular hydrogen bonding and crystal accumulation, falls within a specific temperature range, but the specific values vary depending on the precise synthesis and purification conditions.
When it comes to solubility, because the molecule contains hydroxyl groups, it has a certain hydrophilicity, and it should have a certain solubility in water or polar organic solvents such as methanol and ethanol. However, the molecule also contains a pyridine ring substituted by a halogen atom, which has a certain hydrophobicity, so the solubility may be limited in non-polar solvents such as n-hexane and benzene.
Its density is closely related to the molecular structure. Due to the different types and arrangements of atoms in the molecule, the relative density presents a specific value, which can be roughly measured by relevant theoretical calculations or experiments. In addition, in terms of stability, due to the presence of halogen atoms such as iodine and chlorine, under specific conditions such as high temperature, light, or exposure to specific chemical reagents, halogen atoms may undergo reactions such as substitution and elimination, resulting in structural changes. Therefore, it is necessary to pay attention to environmental factors when storing. It is usually recommended to place in a cool, dry, and dark place.
What are the synthesis methods of (s) 2- (5-chloro-4-iodopyridin-2-ylamino) propan-1-ol?
To prepare (s) -2- (5-chloro-4-iodopyridine-2-ylamino) propane-1-ol, there are many methods for its synthesis, and the following are selected.
First, a suitable pyridine derivative is used as the starting material. First, take the pyridine containing the corresponding substituent, introduce the chlorine atom at the 5th position and the iodine atom at the 4th position, which can be achieved by halogenation reaction. For example, under suitable reaction conditions, select a specific halogenation reagent, precisely control the reaction temperature, time and reagent dosage, and make the halogen atom precisely locate the substitution.
Then, the halogenated pyridine derivative is reacted with the amino-containing propanol derivative. This reaction requires the selection of a suitable base to promote the nucleophilic substitution of the halogen atom on the amino-p-pyridine ring. The strength, dosage and polarity of the reaction solvent all have a great influence on the reaction process and yield. Under mild conditions, the target product can be obtained.
Another way is to build a propanol skeleton first, and then gradually introduce pyridine substituents. Starting with propanol, the hydroxyl group is protected by a suitable protecting group strategy. Then, the amino group is reacted with halogenated pyridine to build a connecting structure. Finally, the protecting group is removed to obtain the target product. In this process, the choice of protecting group is very critical to ensure that it is stable in subsequent reactions and does not affect other groups when removed.
During the synthesis process, precise control of reaction conditions, such as temperature, pH, reaction time, and precise monitoring and purification of intermediates and products, is essential for obtaining high purity (s) -2- (5-chloro-4-iodopyridine-2-ylamino) propane-1-ol.
What are the main uses of (s) 2- (5-chloro-4-iodopyridin-2-ylamino) propan-1-ol?
(S) -2 - (5-chloro-4-iodopyridine-2-ylamino) propane-1-ol is a kind of organic compound. Its main use is in the field of organic synthesis, and it is often important.
In the field of pharmaceutical chemistry, it is often a key intermediate. Due to its unique molecular structure, various functional groups can be introduced by chemical synthesis to build complex drug molecular structures. With this intermediate, compounds with specific pharmacological activities can be created through a series of chemical reactions, or the cornerstone of new drug development.
In the field of materials science, it may also have potential uses. Its special chemical structure may endow the material with different properties, such as affecting the electrical, optical or mechanical properties of the material. For example, it can be combined with other materials, and ingeniously designed to produce composites with special functions to meet the needs of different fields.
Furthermore, on the road of scientific research exploration, (s) -2 - (5-chloro-4-iodopyridine-2-ylamino) propyl-1-ol can be used as a model compound. Scientists can gain the understanding of organic chemistry theory by in-depth exploration of its reaction mechanism and properties, and contribute to the development of related fields.
What are the safety precautions for (s) 2- (5-chloro-4-iodopyridin-2-ylamino) propan-1-ol?
(S) -2 - (5-chloro-4-iodopyridine-2-ylamino) propane-1-ol is a chemical substance. It is related to the safety precautions of this substance. Please listen to me in detail.
This chemical substance is potentially chemically dangerous. It contains halogen atoms such as chlorine and iodine, and some halogen-containing organic compounds may be irritating and toxic. During operation, do not come into direct contact. Wear protective clothing, such as lab clothes and gloves, which should be made to resist chemical corrosion. Also wear a protective eye mask to protect your eyes from accidental spills.
It is essential to operate in a well-ventilated place. Because of its or volatilization of harmful gases, good ventilation can be dispersed in time to prevent the accumulation of inhalation hazards in the air. If in the laboratory, when operating in a fume hood, ensure that harmful gases are discharged through the ventilation system.
Furthermore, the storage of this chemical substance should be cautious. It should be stored in a cool, dry and ventilated place, away from fire and heat sources, to prevent chemical properties from changing due to temperature, humidity and other factors, causing danger. And it should be stored separately from oxidizing agents, reducing agents, etc., because of its chemical structure characteristics, or violent reaction with specific substances.
If you accidentally contact the skin during operation, you should immediately rinse with a large amount of flowing water. The rinsing time should be long enough, and then seek medical treatment. If it splashes into the eyes, it is necessary to quickly rinse with a large amount of water, open the eyelids, fully rinse, and immediately seek medical attention. In the event of a fire, it is necessary to choose a suitable fire extinguishing agent according to its chemical properties, and must not act blindly. In short, when handling this chemical substance, be vigilant at all times and strictly abide by safety regulations.