(s)-methyl 2-(tert-butoxycarbonylamino)-3-iodopropanoate

The chemical structure of (s) -methyl 2 - (tert-butoxycarbonylamino) -3 -iodopropionate is an important content in the field of organic chemistry. Its structure can be viewed as follows:
The main chain of this compound is a propionate structure, and the carboxyl group of propionic acid and the hydroxyl group of methanol are esterified to form an ester group, that is, the -COOCH 🥰 part, which is one of the key structural fragments of the molecule. At the α-carbon position of propionic acid, there is a specific chiral center of the (s) configuration, which endows the molecule with specific stereochemical characteristics.
Furthermore, there is also an amino group attached to α-carbon, but above this amino group, it is protected by tert-butoxycarbonyl (Boc), that is, the -NH (COOC (CH <
)) structure. The introduction of tert-butoxycarbonyl can avoid unnecessary reactions of the amino group in the process of organic synthesis. When the time is right, it can be selectively removed to exert the reactivity of the amino group.
The β-carbon position of propionic acid is connected with an iodine atom, a fragment of -CH < 2 I structure, and an iodine atom. Due to its good departure properties, this compound exhibits unique reactivity in many organic reactions, such as nucleophilic substitution reactions.
In summary, the chemical structure of (s) -methyl 2- (tert-butoxycarbonyl amino) -3 -iodopropionate is composed of ester groups, chiral α-carbons and structural fragments such as protective amino groups attached to them, and iodine atoms on β-carbons. Each part affects each other to determine its chemical properties and reactivity.

(S) -methyl 2 - (tert-butoxycarbonyl amino) -3 -iodopropionate is an important chemical substance in organic synthesis. Its main uses cover the following numbers.
First, in the field of peptide synthesis, it is often used as a key intermediate. Peptide synthesis is related to many fields, such as drug development, biochemical research, etc. The tert-butoxycarbonyl amino group of this compound can effectively protect the amino group and prevent it from participating in unexpected reactions for no reason during the reaction process, ensuring the precise and orderly synthesis process. When appropriate, the tert-butoxycarbonyl can be gently removed to restore the activity of the amino group and participate in the subsequent reaction, which is very powerful in constructing the specific sequence of polypeptides.
Second, in terms of medicinal chemistry, it can be used to create new drugs. The presence of 3-iodine atoms gives the molecule unique reactivity. Iodine atoms can be connected to other organic fragments through a variety of chemical reactions, such as coupling reactions, thereby expanding the structural diversity of molecules, helping to discover novel compounds with biological activities, and opening up paths for the development of specific drugs.
Third, in the study of organic synthesis methodologies, (S) -methyl 2- (tert-butoxycarbonyl amino) -3 -iodopropionate is also a common tool. Chemists can explore new reaction mechanisms and synthesis strategies by studying various reactions in which it participates, and promote the development of organic synthetic chemistry.
Fourth, in the field of modification of bioactive molecules, it can be used to modify existing bioactive molecules. By introducing this structural fragment, the physical and chemical properties of the molecule, such as lipophilicity, polarity, etc., can be changed to optimize the pharmacokinetic properties of bioactive molecules and improve their efficacy and bioavailability.
In conclusion, (S) -methyl 2- (tert-butoxycarbonylamino) -3 -iodopropionate plays an indispensable role in many fields such as organic synthesis and drug development, and has made outstanding contributions to the advancement of related scientific fields.

The synthesis of (s) -methyl-2- (tert-butoxycarbonyl amino) -3-iodopropionate is of great interest in the field of organic synthesis. The synthesis method often involves several steps of reaction.
First, the amino group is protected by tert-butoxycarbonyl (Boc) with a suitable amino acid as the starting material. This is a commonly used protective group strategy to avoid amino interference in subsequent reactions. Usually, the reaction of tert-butoxycarbonyl anhydride (Boc 2O O) with amino acids in an alkaline environment, such as sodium carbonate or triethylamine, can make the amino group protected by Boc, and the corresponding Boc-amino acid derivative can be obtained. In the second case, the carboxyl group is esterified. The esterification reaction between methanol and the above Boc-amino acid derivatives under acid catalysis, such as p-toluenesulfonic acid, is heated and refluxed to obtain (s) -methyl-2- (tert-butoxycarbonylamino) propionate. In the last case, the iodine atom is introduced into the α-carbon of the propionate. The commonly used method is to treat the above ester with a strong base, such as lithium diisopropylamide (LDA), to form an enolate intermediate, and then react with an iodine reagent, such as iodomethane or elemental iodine, to obtain the target product (s) -methyl-2 - (tert-butoxycarbonylamino) -3 -iodopropionate.
When synthesizing, it is necessary to pay attention to the conditions of each step of the reaction, such as temperature, pH, reaction time, etc. After each step of the reaction, it is often necessary to separate and purify, such as column chromatography, recrystallization, etc., to ensure the purity of the product, and then to obtain high-quality (s) -methyl-2 - (tert-butoxycarbonyl amino) -3 -iodopropionate.

(S) -methyl 2 - (tert-butoxycarbonylamino) -3 -iodopropionate is an important compound in organic chemistry. Its physical properties are particularly critical and have a significant impact on many chemical processes.
When it comes to the properties of this compound, it is mostly a colorless to light yellow oily liquid under normal conditions, and the texture is uniform and fluidity. This state is conducive to its participation in various reactions in the solution system. Its morphology makes it suitable for intermolecular interactions and the reactivity can be moderately displayed.
Melting point and boiling point are also important physical properties. However, the exact value varies depending on the purity of the sample and the test conditions. Generally speaking, the melting point is in a relatively low range, indicating that the intermolecular force is not extremely strong. This property makes it easy to change the physical state under moderate heating, which is easy to control during synthesis or processing. The boiling point is relatively high, reflecting that it needs to supply more energy to change from liquid to gaseous state, which is quite meaningful in separation, purification and other operations.
Furthermore, its solubility is also worthy of attention. This compound exhibits good solubility in common organic solvents such as dichloromethane, chloroform, ethyl acetate, etc. This property provides convenience for organic synthesis reactions, because a suitable solvent can be selected to build a reaction system according to the reaction requirements, ensuring that the reactants are fully contacted and promoting the smooth progress of the reaction. However, the solubility in water is poor, which is related to the large proportion of hydrophobic groups in the molecular structure. This property needs to be specially considered in operations or reactions involving the aqueous phase.
In terms of density, it is larger than that of water. If it is in a stratified system, it will be in the lower layer. This property can be used when separating mixed systems containing the compound to assist the separation process by means of density differences.
In addition, the compound has a certain refractive index. This physical constant can be used for analytical work such as purity identification. Because the pure substance has a specific refractive index value, its purity status can be inferred by measurement.

(S) -methyl 2 - (tert-butoxycarbonyl amino) - 3 -iodopropionate, which is a key compound in the field of organic synthesis, is used in many drug development and fine chemical preparation processes.
Looking at its market prospects, since the past, organic synthesis technology has continued to improve, and the demand for high-purity, specific configuration compounds has also continued to rise. (S) -methyl 2 - (tert-butoxycarbonyl amino) - 3 -iodopropionate can be used as an important intermediate in chiral drug synthesis due to its special chiral structure.
In the field of drug research and development, with the deepening of awareness of chiral drugs, many pharmaceutical companies are committed to the creation of chiral drugs. (S) -methyl 2- (tert-butoxycarbonyl amino) -3 -iodopropionate can be converted into chiral drugs with specific pharmacological activities through a series of chemical reactions. Therefore, with the expansion of the chiral drug market, its demand as a key raw material may also rise steadily.
In the preparation of fine chemicals, such as the synthesis of some high-end fragrances, pesticides, etc., or the use of this compound. With people's pursuit of improving quality of life, the high-end fragrance market is gradually expanding; at the same time, the demand for high-efficiency and low-toxicity pesticides is also growing. All of these are addressable market opportunities for (S) -methyl 2- (tert-butoxycarbonyl amino) -3 -iodopropionate.
However, its market development also faces challenges. The process of synthesizing this compound may have high complexity and high cost. To expand market share, researchers and enterprises need to focus on optimizing the synthesis process and reducing production costs. In this way, (S) -methyl 2- (tert-butoxycarbonyl amino) -3 -iodopropionate can occupy a favorable position in the market competition and usher in a broader development prospect.