S N 3 3 Fluoro 4 Iodophenyl 2 Oxooxazolidin 5 Ylmethyl Acetamide
Iodobenzene

S N 3 3 Fluoro 4 Iodophenyl 2 Oxooxazolidin 5 Ylmethyl Acetamide

Fengxi Chemical

Specifications

HS Code

999866

Chemical Formula C12H10FIN2O4
Molar Mass 392.12 g/mol
Chemical Formula C12H10FIN2O4
Molar Mass 394.12 g/mol
Physical State Solid (predicted, as no common data on this specific molecule's state), usually organic amides are solids at room temperature
Solubility In Water Low (due to the non - polar nature of the phenyl group and the relatively hydrophobic nature of the oxazolidinone ring, but some solubility might be attributed to the amide group)
Solubility In Organic Solvents Soluble in polar organic solvents like DMSO, DMF; might have some solubility in chloroform due to the presence of non - polar regions
Pka The amide group might have a pKa in the range of 15 - 20 (approximate value based on similar amide compounds), indicating its weak acidic nature
Logp Positive value (estimated around 2 - 3, suggesting it has some lipophilicity due to the phenyl group)
Chemical Name (s)-n-[3-(3-fluoro-4-iodophenyl)-2-oxooxazolidin-5-ylmethyl]acetamide
Molecular Formula C12H11FIN3O3
Molecular Weight 393.14
Chemical Name (s)-n-[3-(3-fluoro-4-iodophenyl)-2-oxooxazolidin-5-ylmethyl]acetamide
Molecular Formula C12H12FIN2O3
Molecular Weight 392.14
Appearance Unknown
Melting Point Unknown
Boiling Point Unknown
Solubility Unknown
Density Unknown
Pka Unknown
Logp Unknown
Packing & Storage
Packing 100 g of (s)-n-[3-(3 - fluoro - 4 - iodophenyl)-2 - oxooxazolidin - 5 - ylmethyl]acetamide in sealed vial.
Storage Store (s)-n-[3-(3 - fluoro - 4 - iodophenyl)-2 - oxooxazolidin-5-ylmethyl]acetamide in a cool, dry place away from direct sunlight. Keep it in a tightly sealed container to prevent moisture absorption and exposure to air, which could potentially lead to degradation. Avoid storing near sources of heat or reactive chemicals.
Shipping The chemical, N-[3-(3 - fluoro - 4 - iodophenyl)-2 - oxooxazolidin - 5 - ylmethyl]acetamide, will be shipped in containers suitable for chemical substances, ensuring proper protection and compliance with safety regulations during transit.
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(s)-n-[3-(3-fluoro-4-iodophenyl)-2-oxooxazolidin-5-ylmethyl]acetamide (s)-n-[3-(3-fluoro-4-iodophenyl)-2-oxooxazolidin-5-ylmethyl]acetamide (s)-n-[3-(3-fluoro-4-iodophenyl)-2-oxooxazolidin-5-ylmethyl]acetamide
General Information
Frequently Asked Questions
What is the chemical structure of (s) -n- [3- (3-fluoro-4-iodophenyl) -2-oxooxazolidin-5-ylmethyl] acetamide?
The chemical structure of (s) -n- [3- (3-fluoro-4-iodophenyl) -2-oxazolidine-5-ylmethyl] acetamide is like a delicately constructed pavilion composed of various atoms arranged according to specific rules.
Its core structure is the oxazolidinone ring, which has a unique five-element structure. The oxygen and nitrogen atoms are cleverly inlaid, which makes the ring both stable and active. At the 3rd position of the oxazolidinone ring, there is a phenyl group connected. This phenyl group is unusual. The fluorine atom at the 3rd position and the iodine atom at the 4th position are like two loyal guards, occupying a specific position, giving the whole molecule a unique electronic effect and steric resistance.
And at the 5th position of the oxazolidinone ring, it is connected to the acetamide group through methylene. The acetamide group structure is relatively simple, and it is formed by connecting the acetyl group to the amino group. The combination with the oxazolidinone ring is like a mortise and tenon, which makes the whole molecular structure more compact.
In this compound, the length and angle of the chemical bonds between the atoms follow the laws of chemistry, or single bonds are firmly connected, or double bonds are conjugated to produce color, forming a harmonious and orderly chemical structure as a whole, just like the artifacts carefully carved by the ancients. Each part complements each other to form this unique chemical entity.
What are the physical properties of (s) -n- [3- (3-fluoro-4-iodophenyl) -2-oxooxazolidin-5-ylmethyl] acetamide?
(S) -n- [3- (3-fluoro-4-iodophenyl) -2-oxazolidine-5-ylmethyl] acetamide, which is an organic compound. Its physical properties are critical to its application in various fields.
First of all, the appearance of this compound is often white to off-white crystalline powder, fine texture, pure appearance, no obvious color impurities, this appearance feature is easy to distinguish, in the production of medicines or fine chemical products, its purity and quality can be preliminarily judged.
Melting point is also an important physical property. After determination, its melting point is in a specific range, which is of great significance for the identification and purity detection of the compound. In the synthesis process, the melting point can be used as an important indicator to judge whether the product is pure. If the melting point is consistent with the theoretical value, it indicates that the product has high purity; if there is a deviation, it suggests that there may be impurities.
In terms of solubility, the compound exhibits good solubility in organic solvents such as dichloromethane, N, N-dimethylformamide, and can be uniformly dispersed and dissolved to form a clear solution. However, it has poor solubility in water and is only slightly soluble. This difference in solubility provides a basis for its separation, purification and application. In drug development, if it needs to be formulated into a solution dosage form, its solubility needs to be considered, and a suitable solvent needs to be selected to ensure the stability and efficacy of the drug
In addition, the density of the compound is specific, and although the exact value needs to be accurately determined by experiments, the density is indispensable in material calculation, preparation process design, etc., which affects the material ratio and product dosage form design in the production process. Its physical properties are interrelated and jointly determine the behavior and application of the compound in different scenarios, which is of great significance for researchers to further explore its characteristics and expand the application field.
(S) What are the main uses of -n- [3- (3-fluoro-4-iodophenyl) -2-oxooxazolidin-5-ylmethyl] acetamide?
(S) -n- [3- (3-fluoro-4-iodophenyl) - 2-oxazolidine-5-ylmethyl] acetamide is widely used in medicine. Its role in the creation of new antimalarial drugs is extraordinary. Malaria, an ancient disease, has been a disaster for a long time, and everyone has suffered from it. And this compound, which has been explored by many parties, has an outstanding effect on the inhibition of malaria parasites. It can effectively prevent the reproduction and growth of malaria parasites, just like building a strong wall for antimalarial.
In addition, in the field of antibacterial, it can also be used. Bacteria breed, cause various diseases, and disturb people's health. This agent has the ability to inhibit some bacteria, reduce the harm of bacteria, and ensure the safety of the body, just like a guard guarding the city.
And in terms of immune regulation, it has also made a name for itself. The body's immunity is related to health, and immune imbalance is rife with diseases. This compound can fine-tune immunity, bring the body's immunity to a balanced state, and help the body resist external evil, just like correcting the balance of imbalance and restoring the normal state of the body.
In conclusion, (s) -n- [3- (3-fluoro-4-iodophenyl) -2-oxazolidine-5-ylmethyl] acetamide is potentially useful in many fields of medicine, or is a good solution to the problem of disease. To be further studied by Fang family, it will be more effective.
What are the synthesis methods of (s) -n- [3- (3-fluoro-4-iodophenyl) -2-oxooxazolidin-5-ylmethyl] acetamide?
To prepare (s) -n- [3- (3-fluoro-4-iodophenyl) -2-oxazolidine-5-ylmethyl] acetamide, the synthesis method can follow the following steps:
Starting material, select a fluoroiodine-containing aromatic hydrocarbon, such as 3-fluoro-4-iodoaniline, and carry out a condensation reaction with aldehyde substances (such as formaldehyde) under suitable conditions. This step requires choosing a suitable catalyst, such as an acid catalyst, to promote the condensation of the two to form a nitrogen-containing heterocyclic precursor.
Then, the precursor is acetylated with an acetylating reagent, such as acetyl chloride or acetic anhydride, in the presence of a base. The choice of base is crucial. Common bases such as pyridine and triethylamine can assist in the smooth progress of the reaction, prompting the acetyl group to replace the hydrogen on the nitrogen atom to obtain the key intermediate of the target product.
Furthermore, for the construction of oxazolidinone rings, intermediates and carbonates, such as diethyl carbonate, can be heated under specific reaction conditions and cyclized under the action of a catalyst. This process requires attention to the control of reaction temperature and time. If the temperature is too high or the time is too long, side reactions may occur. In the
reaction, the choice of solvent is also important. Commonly used organic solvents such as dichloromethane, N, N-dimethylformamide, etc. can be selected according to the characteristics and needs of each step of the reaction to ensure the solubility of the reactants and the smooth progress of the reaction.
After the reaction is completed, it needs to be separated and purified. The product can be extracted with a suitable organic solvent by extraction method first, and then further purified by column chromatography. The suitable eluent is selected. According to the difference in the distribution coefficient between the product and the impurities in the stationary phase and the mobile phase, the separation of the two is achieved. Finally, a pure (s) -n- [3- (3-fluoro-4-iodophenyl) -2-oxazolidine-5-ylmethyl] acetamide is obtained.
(S) What is the market outlook for -n- [3- (3-fluoro-4-iodophenyl) -2-oxooxazolidin-5-ylmethyl] acetamide?
(S) -n- [3- (3-fluoro-4-iodophenyl) -2-oxazolidine-5-ylmethyl] acetamide, an organic compound. Looking at its market prospects, it should be studied from multiple dimensions.
From the perspective of the pharmaceutical field, organic compounds containing fluoride and iodine often have unique activities in drug development. Fluorine atoms can change the fat solubility and metabolic stability of compounds, etc. Iodine atoms may participate in specific physiological effects. If this compound has good biological activity and pharmacological properties, and can meet the unmet clinical needs, such as showing unique curative effects on certain diseases, it will have a wide world in the pharmaceutical market. Or it can be developed into a drug, bringing good news to patients and creating huge profits for pharmaceutical companies.
In the chemical industry, as an intermediate, if its synthesis process is feasible and the cost is controllable, a series of high value-added products can be derived. It can be supplied to fine chemical companies for the production of specialty chemicals, functional materials, etc. With the growth of demand for new compounds in the chemical industry, if large-scale production can be achieved to meet the market's requirements for their quantity and quality, it may occupy an important position in the chemical industry chain.
However, its market prospects also pose challenges. The synthesis of this compound may require complex processes and special raw materials, resulting in high production costs and affecting market competitiveness. And the road to drug development is long and risky. In preclinical and clinical trials, or due to various factors, it cannot be successfully launched. Furthermore, the market competition is fierce, and if there are alternatives with similar effects and lower costs, it will also impact its market share.
In summary, the market prospect of (s) -n- [3- (3-fluoro-4-iodophenyl) -2-oxazolidine-5-ylmethyl] acetamide has potential, but it also needs to overcome many obstacles such as synthesis costs, R & D risks, and competitive pressure to emerge in the market.