What is the chemical structure of Sodium 4-o- (4-hydroxy-3,5-diiodophenyl) -3,5-diiodo-l-tyrosine?
This compound is named 4-o- (4-hydroxy-3,5-diiodophenyl) -3,5-diiodol-L-sodium tyrosine, and its chemical structure can be gradually resolved from the following parts.
First of all, tyrosine is the basic framework of this structure. L-tyrosine is a chiral amino acid, and its structure contains a benzene ring. On the benzene ring, β-carbon is connected to amino and carboxyl groups, and the 4-position of the benzene ring is hydroxy substituted.
On this basis, 3,5-diiodol-L-tyrosine introduces iodine atoms at the 3,5-position of the L-tyrosine benzene ring.
Further, 4-o- (4-hydroxy-3,5-diiodophenyl) -3,5-diiodol-L-tyrosine is based on the above structure, connecting another 4-hydroxy-3,5-diiodophenyl group through oxygen atoms.
Finally, the compound is in the form of sodium salt, which means that the carboxyl group exists in the form of sodium carboxylate salt. The overall chemical structure presents a more complex form of sodium salt of organic compounds with polyiodine substitution and amino acid structural units. The introduction of multiple iodine atoms will significantly affect its physicochemical properties and biological activities.
What are the main uses of Sodium 4-o- (4-hydroxy-3,5-diiodophenyl) -3,5-diiodo-l-tyrosine?
Sodium 4 - o - (4 - hydroxy - 3,5 - diiodophenyl) - 3,5 - diiodo - L - tyrosine is sodium iodoseronine. The following is an ancient saying to describe its main uses.
Sodium iodoseronine is used in medical medicine and its use is quite critical. First, it is often used in hypothyroidism. In today's people, either due to insufficient endowments or the invasion of external pathogens, the thyroid can be reduced, the qi and blood cannot run smoothly, and the organs are lost in warmth. Iodoseronine sodium can replenish the lack of thyroxine, reconcile qi and blood, nourish the organs, and return the body to normal.
Second, in the field of diagnosing thyroid function, it also has important functions. Doctors want to understand the exact condition of the patient's thyroid gland, and often use this medicine as a reference. After administration, observe the reaction of the body, such as the circulation of qi and blood, the transportation of the viscera, so as to observe the reality, rise and fall of thyroid function in detail, so as to help accurate diagnosis and lay the foundation for the treatment of diseases.
Third, in some special diseases, such as myxedema coma and other critical conditions, iodoseronin sodium can be used as first aid medicine. When the patient falls into such a critical situation, the qi and blood are exhausted, and the viscera will fail. This medicine can quickly invigorate the yang qi, promote the secretion of thyroid hormone, make the qi and blood restart, and the viscera will be revived. When the patient is in danger, it is actually a weapon in the hands of the doctor.
What are the physical properties of Sodium 4-o- (4-hydroxy-3,5-diiodophenyl) -3,5-diiodo-l-tyrosine?
Sodium 4 - o - (4 - hydroxy - 3,5 - diiodophenyl) - 3,5 - diiodo - L - tyrosine is an organic compound, often called sodium tyrosine iodide salt. Its physical properties are unique, let me tell you in detail.
Looking at its appearance, it is usually in the state of white to quasi-white crystalline powder, which makes it easy to distinguish among many substances, just like in the vast sea of people, people wearing unique clothes are very eye-catching. Its texture is delicate, and it can be touched lightly, as if it can sense the gentle caress of time.
Talking about solubility, this compound can show certain solubility properties in water. Just like a fish entering water, it can gradually disperse in the gentle embrace of water molecules, fuse with water, and form a uniform system. However, its solubility in organic solvents is different. In some organic solvents, or the solubility is very small, just like a lonely person, it is difficult to integrate into certain groups.
Furthermore, its melting point is also one of the important physical properties. When the temperature gradually rises to a specific value, the compound will quietly transform from solid to liquid, completing a wonderful transformation of material form. This melting point value is like a key to accuracy, providing a key clue for identifying the compound.
In addition, the stability of the compound cannot be ignored. Under suitable environmental conditions, it can exist relatively stably, just like a calm person, not easily shaken by external trifles. However, if the environmental conditions are harsh, such as high temperature, high humidity or strong light exposure, its structure may be affected, just like the cornerstone of a building, if eroded, the building will also crumble.
In summary, the physical properties of Sodium 4-o- (4-hydroxy-3,5-diiodophenyl) -3,5-diiodo-L-tyrosine cover appearance, solubility, melting point and stability, and these properties are intertwined to outline the unique physical "picture" of this compound.
What is the synthesis method of Sodium 4-o- (4-hydroxy-3,5-diiodophenyl) -3,5-diiodo-l-tyrosine?
Sodium 4-o- (4-hydroxy-3,5-diiodophenyl) -3,5-diiodo-L-tyrosine, that is, 4-O- (4-hydroxy-3,5-diiodophenyl) -3,5-diiodophenyl-L-sodium tyrosine, the synthesis method of this compound, let me explain in detail.
To synthesize this compound, the choice of starting materials is very critical. L-tyrosine is often used as the root starting material because it has the necessary structure to build the basic skeleton of the target product.
First, the iodine substitution reaction is carried out on a specific position above L-tyrosine. During the iodine substitution reaction, suitable reagents and reaction conditions need to be carefully selected. Iodine elements and appropriate catalysts are often used in a specific solvent system. For example, in some organic solvents, parameters such as temperature and reaction time are regulated to promote the precise substitution of iodine atoms at the 3,5 position to obtain 3,5-diiodine-L-tyrosine. This step requires careful control of the reaction process to prevent excessive iodine substitution or substitution position deviation.
Then, modify the position of another phenoxy group on the benzene ring. The target structure was initially constructed by introducing a group containing 4-hydroxy-3,5-diiodophenyl. This process may require the help of classical nucleophilic substitution reactions in organic synthesis. Select a suitable halogen or active intermediate, react with 3,5-diiodol-L-tyrosine, and react the two under a suitable base and reaction environment to form a carbon-oxygen bond connection to construct 4-O- (4-hydroxy-3,5-diiodophenyl) -3,5-diiodol-L-tyrosine.
Finally, the above product is converted into sodium salt form. Alkaline substances can be used to react with the product to promote the neutralization of acidic check points such as hydroxyl groups to generate corresponding sodium salts. Sodium hydroxide and other basic reagents are selected, and the reaction is carried out in an appropriate solvent. After separation and purification, pure Sodium 4-o- (4-hydroxy-3,5-diiodophenyl) -3,5-diiodo-L-tyrosine products are finally obtained. The whole synthesis process requires strict control of the reaction conditions at each step, and careful monitoring and purification of the products to obtain high-purity target products.
What are the precautions for using Sodium 4-o- (4-hydroxy-3,5-diiodophenyl) -3,5-diiodo-l-tyrosine?
Sodium + 4 - o - (4 - hydroxy - 3,5 - diiodophenyl) - 3,5 - diiodo - l - tyrosine is a chemical substance. When using this substance, many matters need to be paid attention to.
First of all, pay attention to safety. This substance may be chemically active, and appropriate protective equipment must be worn during operation, such as gloves, goggles and laboratory clothes, to prevent it from contacting the skin and eyes. If it is inadvertently touched, rinse with plenty of water quickly and seek medical attention according to the specific situation.
In addition, in the use environment, it is advisable to choose a well-ventilated space to avoid the accumulation of harmful substances and air pollution, which will damage the user's health. And the operation process should be kept away from fire and heat sources, because of its chemical properties or dangerous reactions in case of fire or heat.
Accurate dosage is also key. Accurately weigh the required amount and operate according to the established procedures of experiment or production to prevent abnormal reaction results due to dosage deviation or other adverse consequences.
In addition, storage should not be neglected. It should be stored in a dry, cool and dark place, and the container should be selected according to its chemical characteristics to ensure its stability and avoid deterioration affecting the use effect.
In conclusion, when using Sodium + 4 - o - (4 - hydroxy - 3,5 - diiodophenyl) - 3,5 - diiodo - l - tyrosine, all aspects of safety protection, environmental control, accurate dosage and proper storage need to be carefully considered in order to ensure the smooth use process and achieve the intended purpose without safety risks.