As a leading Tert-Butyl 4-(4-Iodopyrazol-1-Yl)Piperidine-1-Carboxylate supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of Tert-butyl 4- (4-iodopyrazol-1-yl) piperidine-1-carboxylate
Eh, this "Tert-butyl 4- (4 - iodopyrazol - 1 - yl) piperidine - 1 - carboxylate" has the name of the compound. To understand its chemical properties, let me tell you.
Among them, "Tert-butyl", that is, tert-butyl, is a group containing three methyl groups in the same carbon atom, which is shaped like a fork and has characteristics. "Piperidine - 1 - carboxylate", the name of piperidine - 1 - carboxylate, piperidine is a six-membered nitrogen-containing compound, and its nitrogen atom has a carboxylate group in the first position. The other part of the carboxylic acid ester group, which is represented by the tert-butyl group, forms a whole.
And "4 - (4 - iodopyrazol - 1 - yl) ", which is expressed at the 4th position of piperidine, has a 4 - iodopyrazol - 1 - group. For pyrazoles, the five-membered nitrogen atom contains a nitrogen atom and a nitrogen atom. Here, the fourth position of pyrazole has an iodine atom substitution, and the fourth position of the first position is a piperidine atom.
In this way, the parts are interconnected, thus forming the "Tert-butyl 4 - (4 - iodopyrazol - 1 - yl) piperidine - 1 - carboxylate". In this case, the interaction of various radicals affects their physical and chemical properties, which are in the fields of synthesis and chemical chemistry, or have important uses.
What are the main uses of Tert-butyl 4- (4-iodopyrazol-1-yl) piperidine-1-carboxylate
Tert-butyl 4- (4-iodopyrazole-1-yl) piperidine-1-carboxylic acid ester, which has a wide range of uses. In the field of pharmaceutical research and development, it is often a key intermediate. The structure of Geinpyrazole and piperidine is common in many bioactive molecules. With this compound, it can be chemically modified to construct molecules with specific pharmacological activities, or used to create new drugs to fight various diseases, such as inflammation and tumors.
It also plays an important role in the field of organic synthesis. With the active chemical properties of iodine atoms, it can participate in many classical organic reactions, such as coupling reactions. By coupling with different organic reagents, complex and diverse organic compounds can be derived, which lays the foundation for the synthesis of novel functional materials and natural products. Furthermore, tert-butyl and piperidine-1-carboxylate can affect the spatial structure and electron cloud distribution of molecules during the reaction process, thereby regulating the selectivity and rate of the reaction, and assisting synthetic chemists to achieve precise synthesis of the target product.
It also has potential uses in the field of materials science. Through rational molecular design and modification, it may endow materials with specific photoelectric properties and thermal stability. For example, introducing it into the skeleton of polymer materials is expected to improve the properties of materials to meet the special needs of materials in different application scenarios.
What are the synthesis methods of Tert-butyl 4- (4-iodopyrazol-1-yl) piperidine-1-carboxylate
To prepare tert-butyl 4- (4-iodopyrazole-1-yl) piperidine-1-carboxylate, there are many methods, and the common ones are as follows.
First, the compound containing the structure of pyrazole and piperidine is used as the starting material. First, a suitable pyrazole derivative is taken, and a specific position in it is halogenated to introduce iodine atoms to obtain 4-iodopyrazole intermediates. The key carbon-nitrogen bond of tert-butyl 4- (4-iodopyrazole-1-yl) piperidine-1-carboxylate is constructed by nucleophilic substitution reaction with the compound containing piperidine structure under suitable base and reaction conditions. This process requires careful selection of solvents, such as N, N-dimethylformamide, etc., to facilitate the reaction.
Second, the piperidine ring can be modified first, and a suitable leaving group can be introduced at the 4-position of piperidine. Then 4-iodopyrazole is used as the nucleophilic reagent to attack the leaving group on the piperidine ring in an alkaline environment, and nucleophilic substitution occurs. The basic reagents can be selected from potassium carbonate, potassium tert-butanol, etc., which are optimized according to the activity and conditions of the reaction substrate. At the same time, the reaction temperature and time also need to be fine-tuned to improve the yield of the product.
Third, the strategy of gradually constructing heterocycles can also be considered. First, part of the structural fragments of the pyrazole ring and the piperidine ring are constructed, and then the target product is finally obtained through cyclization reaction and subsequent modification. Although this path is more complicated, it may have unique advantages for some specific starting materials, which can avoid some side reactions and improve the purity of the product
In conclusion, the synthesis of tert-butyl 4- (4-iodopyrazole-1-yl) piperidine-1-carboxylic acid ester requires careful selection of synthesis methods according to existing raw materials, reaction equipment and target product requirements, and careful optimization of reaction conditions to achieve the ideal synthesis effect.
What are the physical and chemical properties of Tert-butyl 4- (4-iodopyrazol-1-yl) piperidine-1-carboxylate
Tert-butyl 4- (4-iodopyrazole-1-yl) piperidin-1-carboxylate, the physical and chemical properties of this substance are quite critical. Its appearance is often white to off-white solid, under normal conditions, stable and not easily changed.
Looking at its solubility, it can show good solubility in organic solvents, such as common chloroform and dichloromethane, because some groups in the molecular structure can form specific interactions with organic solvents. However, in water, its solubility is poor, and the overall hydrophobicity of the molecules is relatively strong, making it difficult to fully blend with water molecules.
As for the melting point, after fine determination, it is about a specific temperature range, which has a significant impact on its behavior during heating or preparation-related processes. When heated to this temperature, a physical state transition will occur, and the solid state will gradually melt into a liquid state.
Its chemical stability can be maintained under generally mild conditions. However, when encountering strong acids, bases or strong oxidants, some chemical bonds in the molecular structure, such as ester groups, are vulnerable to attack and react, resulting in structural changes and other products. The conjugated system of the iodine atom, pyrazolyl and piperidine ring in the molecule also affects its spectral properties, and the characteristic absorption peak can be observed at a specific wavelength, which is of great significance in analysis and identification.
Tert-butyl 4- (4-iodopyrazol-1-yl) piperidine-1-carboxylate in the market price range
Looking at this question, I am inquiring about the price range of tert-butyl 4- (4-iodopyrazole-1-yl) piperidine-1-carboxylic acid ester in the market. However, the price of this compound is difficult to generalize, and it is affected by many factors.
The simplicity of its preparation process and the ease of availability of raw materials are all factors that affect the price. If the preparation requires rare raw materials, or the process is complicated, and special conditions and catalysts are required after multiple steps, the cost will be high, and the price will also rise.
Furthermore, the relationship between market supply and demand is also key. If the demand is strong and the supply is limited, the price will rise; conversely, if the market is saturated, the supply will exceed the demand, and the price will tend to fall.
In addition, the difference between manufacturers also leads to different prices. Large factories may have lower costs and more competitive prices due to scale effects; small factories may have higher prices due to low output and high costs.
In common cases, if this compound is used for scientific research, the price may be higher due to small quantities and high purity requirements. Based on the market conditions of similar compounds in the past, the price per gram may range from hundreds to thousands of yuan. However, if it is used in industrial production, the price may be reduced due to large demand and large quantities, and the price per kilogram may be between thousands and tens of thousands of yuan. But this is only a rough guess, and the actual price should be subject to the specific market inquiry.
