As a leading Tert-Butyl 5-Iodopyridin-2-Ylcarbamate supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of Tert-butyl 5-iodopyridin-2-ylcarbamate?
The chemical structure of tert-butyl 5-iodopyridin-2-ylcarbamate (Tert-butyl 5-iodopyridin-2-ylcarbamate) is composed of several parts cleverly spliced together.
Pyridine ring, which is a six-membered nitrogen-containing heterocycle, has aromatic properties and plays a key role in organic chemical systems. Its nitrogen atom exhaled ring has unique electronic properties and reactivity. In the structure of tert-butyl 5-iodopyridine-2-ylcarbamate, the pyridine ring is the core skeleton, supporting the entire molecular structure.
5-Iodine substituent, attached to pyridine ring at position 5. Iodine atoms have significant effects on molecular physical and chemical properties due to their large atomic radius and electronegativity. It can change molecular polarity, act as a leaving group in nucleophilic substitution, coupling and other reactions, and participate in many organic synthesis reactions, greatly expanding the reaction possibility of this compound.
2-carbamate moiety, containing carbamate functional group (-NHCOO-). Carbamate compounds have a wide range of uses and biological activities, and are common in the fields of pesticides and medicine. In this molecule, carbamate is connected to the pyridine ring at position 2 at one end, and tert-butyl at the other end.
Tert-butyl, i.e. -C (CH
, is a bulky alkyl group. Due to its large steric barrier, it can protect the groups connected to it, affect the selectivity of molecular reactions, and also affect the physical properties of compounds, such as solubility, melting point, boiling point, etc.
In the chemical structure of tert-butyl 5-iodopyridine-2-ylcarbamate, each part interacts and coordinates, endowing the compound with unique physical and chemical properties and reactivity, and has broad potential applications in organic synthesis, drug development and other fields.
What are the main uses of Tert-butyl 5-iodopyridin-2-ylcarbamate?
Tert-butyl 5-iodopyridine-2-carbamate has a wide range of uses. In the field of organic synthesis, it is often a key intermediate. The characteristics of the structure of Geyne pyridine ring, iodine atom and carbamate can be used to construct many complex organic molecules through various chemical reactions.
In pharmaceutical chemistry, its role cannot be ignored. Pyridine structure is common in many drug molecules, and iodine atoms can enhance the lipophilic properties of molecules and affect the interaction between drugs and targets. Carbamate also has unique biological activities. Using this substance as a starting material may enable the synthesis of new drugs with specific pharmacological activities, providing the possibility for the development of new drugs.
In the field of materials science, it may be involved in the preparation of functional materials. After appropriate reactions, it is introduced into polymer materials, and by virtue of its structural characteristics, or endowing materials with special optical and electrical properties, it provides a path for the development of new functional materials.
And because of its active iodine atom, it can carry out coupling reactions, connect with other organic fragments, expand the molecular structure, and play an important role in the construction of complex organic frameworks. It helps the continuous development of organic synthetic chemistry and provides more novel compound options for various fields.
What is the synthesis method of Tert-butyl 5-iodopyridin-2-ylcarbamate?
The synthesis of tert-butyl 5-iodopyridine-2-carbamate is a key research in the field of organic synthesis. To synthesize this compound, the following steps are usually taken.
The first step is to prepare suitable pyridine derivatives. Pyridine is often used as the starting material, and iodine atoms are introduced at the 2-position of the pyridine ring through a halogenation reaction. This halogenation reaction can be carried out in a suitable solvent, such as acetic acid or dichloromethane, at a certain temperature and time.
In the second step, the obtained 5-iodopyridine derivative is converted into carbamate. In this process, 5-iodopyridine is first reacted with a suitable amination reagent to generate 5-iodopyridine-2-amine. Common amination reagents, such as ammonia derivatives or azide compounds, achieve this conversion through nucleophilic substitution or reduction.
In the last step, 5-iodopyridine-2-amine reacts with tert-butyl chloroformate in the presence of a base to generate tert-butyl 5-iodopyridine-2-carbamate. Commonly used bases, such as triethylamine, potassium carbonate, etc., and the reaction solvent can be dichloromethane, tetrahydrofuran, etc. This reaction should be controlled at a suitable reaction time between low temperature and room temperature to achieve a higher yield.
During the whole synthesis process, the reaction conditions of each step need to be carefully controlled. The proportion of reactants, reaction temperature, time and solvent have a significant impact on the yield and purity of the product. In the synthesis, thin layer chromatography (TLC), nuclear magnetic resonance (NMR), mass spectrometry (MS) and other analytical methods are needed to monitor the reaction process and confirm the structure of the product. In this way, tert-butyl 5-iodopyridine-2-carbamate is obtained.
What are the physical properties of Tert-butyl 5-iodopyridin-2-ylcarbamate?
Tert-butyl 5-iodopyridine-2-carbamate is an organic compound with unique physical properties. Its appearance may be white to off-white crystalline powder, and it presents a specific crystal structure in the solid state, which affects many of its properties.
Discusses the melting point, or in a specific temperature range, the temperature is the critical value for a substance to change from a solid state to a liquid state. This property is crucial for the purification and identification of compounds. For example, in the process of separation and purification, the measurement of melting point can help determine the purity of the substance.
In terms of solubility, it may have a certain solubility in common organic solvents such as dichloromethane and chloroform, but it may have a very low solubility in water. This is because its molecular structure contains hydrophobic groups, which makes it difficult to dissolve in water with strong polarity. This solubility characteristic is of great significance in organic synthesis reactions. For example, the choice of reaction solvent depends on its solubility, so that the reaction can be carried out efficiently.
In addition, the density of tert-butyl 5-iodopyridine-2-carbamate is also an important physical property. Although the exact value needs to be determined experimentally, the density is related to the distribution and behavior of substances in different media. For example, in a mixed solvent system, the density difference will affect its location and diffusion. Its stability cannot be ignored, and it may be relatively stable under normal temperature, pressure and conventional storage conditions. However, in case of extreme conditions such as high temperature, strong acid, and strong base, some chemical bonds in the molecular structure may break, triggering chemical reactions and causing changes in its structure and properties. In short, these physical properties are of great significance for its application in organic synthesis, drug development, and other fields.
Tert-butyl 5-iodopyridin-2-ylcarbamate what to pay attention to when storing and transporting
Tert-butyl 5-iodopyridine-2-carbamate This compound requires attention to many key matters during storage and transportation.
First environmental conditions. This compound is sensitive to temperature and humidity. It should be stored in a cool and dry place to prevent it from decomposing due to excessive temperature or moisture deterioration due to excessive humidity. The temperature should be controlled between 5 and 25 degrees Celsius, and the relative humidity should not exceed 60%.
Furthermore, light will also affect its stability. It should be stored in a dark place, preferably in a brown bottle or a container with a shaded package, so as not to cause its chemical reaction due to light and damage its quality.
When transporting, the packaging must be sturdy. Appropriate packaging materials should be selected to ensure that it will not be damaged and leaked due to bumps and collisions during transportation. If it is packed in a thick plastic bottle or glass bottle, the outer cushioning material, such as foam, sponge, etc., is placed in a sturdy carton.
In addition, tert-butyl 5-iodopyridine-2-carbamate may be toxic and dangerous. During handling, operators should wear appropriate protective equipment, such as gloves, protective glasses, protective clothing, etc., to prevent contact with the skin or inhalation of its dust and endanger health. And during transportation, it is necessary to strictly follow the relevant regulations on the transportation of dangerous chemicals, and to separate them from other items such as food and medicine to ensure safe transportation.
