Tert Butyl S 1 Amino 3 4 Iodophenyl 1 Oxopropan 2 Yl Carbamate

This compound is called tert-butyl [ (S) -1-amino-3- (4-iodophenyl) -1-oxopropyl-2-yl] carbamate. Its chemical structure can be resolved as follows:
First, "tert-butyl" indicates the presence of a group of (CH
. "Carbamate" has a structure of R-O-C (= O) -NH-R '. In this compound, tert-butyl is attached at one end and [ (S) -1-amino-3- (4-iodophenyl) -1-oxopropyl-2-yl] at the other end.
For the [ (S) -1-amino-3- (4-iodophenyl) -1-oxopropyl-2-yl] fraction, " (S) " indicates its configuration is S-type. This part of the main chain has a propyl structure, with an oxygen generation (i.e. carbonyl C = O) at position 2, an amino-NH ² at position 1, and a 4-iodophenyl group at position 3. 4-iodophenyl indicates that the benzene ring has an iodine atom substituted at the para-position (position 4) connected to the main chain.
Overall, the chemical structure of the compound is composed of tert-butyl linked to (S) -1-amino-3- (4-iodophenyl) -1-oxo-propyl-2-yl through carbamate bonds. Tert-butyl provides certain steric resistance and stability, while (S) -1-amino-3- (4-iodophenyl) -1-oxo-propyl-2-yl moiety of amino, carbonyl and iodophenyl may endow the compound with specific reactivity and biological activity properties. The various parts of the whole structure interact with each other and jointly determine the chemical and physical properties of the compound.

Tert-butyl [ (s) -1 - amino - 3- (4 - iodophenyl) -1 - oxopropan - 2 - yl] carbamate, the Chinese name is often (S) -1 - amino - 3- (4 - iodophenyl) -2 - (Boc - amino) acetone, which has a wide range of uses.
First, in the field of pharmaceutical chemistry, it is a key intermediate for the creation of many drugs. Many compounds with specific pharmacological activities need to be synthesized as starting materials. For example, when developing small molecule drugs targeting specific disease targets, their unique structures can be transformed into pharmacoactive groups that are tightly bound to the target through a series of reactions, paving the way for the development of new drugs.
Second, in the field of organic synthetic chemistry, it is an important building block for the construction of complex organic molecular structures. Because it contains multiple reactive functional groups, such as amino, carbonyl and iodophenyl groups, chemists can modify and expand them through various organic reactions, such as nucleophilic substitution, coupling reactions, etc., to construct organic molecules with diverse structures and high complexity, which contribute to the development of organic synthetic chemistry.
Third, in terms of biological activity research, its structure is similar to that of some active substances in living organisms. Researchers can explore the relationship between structure and activity by derivatization, thus uncovering potential biological activities and providing direction for the development of new biological regulators or therapeutic drugs.

To prepare Tert - butyl [ (s) -1 - amino - 3 - (4 - iodophenyl) -1 - oxopropan - 2 - yl] carbamate, the following ancient method can be carried out.
First, (s) -2 - amino - 3 - (4 - iodophenyl) propanoic acid as the starting material. Take an appropriate amount of this acid, place it in a clean reaction vessel, and dissolve it in a suitable organic solvent. Commonly used such as dichloromethane, N, N - dimethylformamide, etc., depending on the specific needs of the reaction.
Secondary acid binding agents, such as triethylamine, pyridine, etc. The amount of acid binding agent needs to be precisely controlled, usually slightly more than the starting acid, in order to neutralize the acid generated by the reaction and promote the positive progress of the reaction.
Then slowly add tert-butoxycarbonylation reagents, such as di-tert-butyl dicarbonate (Boc O2 O). The speed of dropwise addition should be slow to prevent the reaction from being too violent. The reaction temperature is also critical, and it is usually controlled at a low temperature, such as between 0 and 5 ° C, to facilitate the smooth occurrence of the reaction.
After the dropwise addition is completed, the reaction system is gradually warmed to room temperature, and the reaction is continuously stirred to make the reaction fully proceed. This process requires thin-layer chromatography (TLC) to monitor the reaction progress to determine the reaction endpoint. When the raw material point disappears and the product point
After the reaction is completed, pour the reaction solution into a mixed system composed of an appropriate amount of water and an organic solvent, such as ethyl acetate and water. Shake and stratify, and collect the organic phase. The aqueous phase is extracted several times with an organic solvent, and the organic phases are combined.
The organic phase is dried with anhydrous sodium sulfate. After filtering out the desiccant, the organic solvent is removed by vacuum distillation to obtain a crude product.
The crude product needs to be purified by column chromatography. Select an appropriate silica gel column and elute with a suitable eluent. The mixture of petroleum ether and ethyl acetate is commonly used, and the ratio of the two is adjusted according to the polarity of the product. Collect the fractions containing the target product and steam off the solvent to obtain pure Tert-butyl [ (s) -1 -amino-3- (4 -iodophenyl) -1 -oxopropan-2 -yl] carbamate. The whole process requires fine operation and attention to the condition control of each step to obtain the ideal yield and purity.

Tert-butyl [ (S) -1-amino-3- (4-iodophenyl) -1-oxopropyl-2-yl] carbamate, this substance is in the form of white to off-white crystalline powder, stable at room temperature, and has a certain tolerance to light and heat. The melting point is between 110-114 ° C, and the melting point will gradually change from solid to liquid. Its solubility is unique, soluble in organic solvents such as dichloromethane, N, N-dimethylformamide, and has low solubility in water.
This substance has amino, ester, iodophenyl and other active groups, and is chemically active. Amino groups can undergo acylation and alkylation reactions, react with acid chloride and acid anhydride to form amides, and react with halogenated hydrocarbons to obtain secondary amines or tertiary amines; ester groups can be hydrolyzed, and under the catalysis of acids or bases, carboxylic acids and alcohols or carboxylic salts and alcohols are generated respectively; iodine atoms in iodophenyl groups can participate in nucleophilic substitution reactions and are replaced by other groups.
Because of its chemical properties, it is an important intermediate in the field of organic synthesis and is often used to construct complex structural compounds. In drug research and development, it is modified with its active groups to synthesize compounds with specific pharmacological activities, providing key raw materials for the creation of

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