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What is the chemical structure of Uridine, 5-iodo-2 '-o-methyl- (8ci, 9ci)?
This is a question about the chemical structure of "Uridine, 5-iodo-2 '-o-methyl - (8ci, 9ci) ". Let me know in detail.
This substance is called 5-iodo-2' -O-methyluridine. Uridine is a nucleoside compound, which is formed by connecting uracil and ribose through β-glycoside bonds.
Now in its structure, iodine atoms are introduced into the carbon atom at position 5. This iodine atom has a large atomic radius and electronegativity, which has a great impact on the electron cloud distribution and spatial structure of the molecule. Furthermore, the methyl group is attached to the 2 '-O position, that is, the 2' oxygen atom of ribose. The introduction of methyl group changes the lipophilicity of the molecule and affects its solubility in different solvents. And because methyl group is the power supply group, it will affect the electron cloud density of the molecule as a whole, and then change its chemical activity.
In this way, the chemical structure of 5-iodine-2 '-O-methyluridine consists of uracil and ribose to form the basic skeleton, and the 5-iodine atom and the 2' -O-position methyl group are its characteristic substituents. This unique structure endows the compound with different physical and chemical properties.
What are the main uses of Uridine, 5-iodo-2 '-o-methyl- (8ci, 9ci)?
"Tiangong Kaiwu" is a masterpiece of ancient technology, but there is no record of "Uridine, 5-iodo-2 '-o-methyl - (8ci, 9ci) ". The modern chemical name of this substance was not involved in ancient times.
This substance is used in modern times and is mainly widely used. First, in the field of pharmaceutical research, or to develop key intermediates for new drugs. Scientists use this to explore its chemical properties to develop drugs for specific diseases, such as antiviral, anti-tumor drugs, etc. By modifying its chemical structure, drugs with better efficacy and fewer side effects may be obtained. Second, in biochemical experiments, it may be used as a marker or probe. Due to the presence of special atoms such as iodine, they can be used to track the activities of biomolecules, enabling researchers to gain insight into chemical reactions and molecular mechanisms in organisms. For example, in nucleic acid research, it helps to understand nucleic acid synthesis, metabolism and interactions. Third, in the field of organic synthesis, it provides starting materials or key modules for the construction of complex organic molecules. Chemists use various reactions to build organic compounds with diverse structures, expand the boundaries of organic synthesis chemistry, and lay the foundation for the development of materials science, pharmaceutical chemistry and many other fields.
What are the physical properties of Uridine, 5-iodo-2 '-o-methyl- (8ci, 9ci)?
5-Iodine-2 '-O-methyluridine (8CI, 9CI) is one of the organic compounds. Looking at its physical properties, this substance may be a white to off-white crystalline powder under normal conditions. This color state is often possessed by many organic compounds. Because of its orderly arrangement of molecular structures, light scattering presents this state.
When it comes to solubility, it is slightly soluble in organic solvents, such as dichloromethane, N, N-dimethylformamide, etc. This is due to the interaction between the polar groups distributed inside the compound and the organic solvent molecules, such as van der Waals forces and hydrogen bonds. However, in water, its solubility is poor, due to the large proportion of the hydrophobic part of the molecule as a whole, it is difficult to form an effective interaction with water molecules.
In terms of melting point, it has been experimentally determined that it is about a specific temperature range, and this melting point value is determined by the intermolecular force and crystal structure. The intermolecular force is strong, and the crystal structure is regular, so a higher energy is required to destroy the lattice, resulting in a higher melting point.
In addition, the stability of this substance to light and heat is also an important physical property. Under light, functional groups such as iodine atoms in the molecule or excitation cause structural changes; when heated, with the increase of temperature, the molecular vibration intensifies, reaching a certain extent, chemical bonds break, decomposition and other reactions occur. Its physical properties are of great significance in chemical synthesis, drug development and other fields, and are related to the selection of reaction conditions, product separation and purification.
What are the synthesis methods of Uridine, 5-iodo-2 '-o-methyl- (8ci, 9ci)?
To prepare 5-iodine-2 '-O-methyluridine (this name comes from the 8CI, 9CI nomenclature), you can follow the following ancient method.
Take the ribose first, and protect its 2' -hydroxyl group with methyl in an appropriate way. In this step, you need to choose a mild methylating agent, such as dimethyl sulfate, and slowly react in an alkaline environment to control the reaction conditions. Do not methylate other hydroxyl groups of the ribose. Wait for 2 '-O-methylribose to obtain it, and then condensate it with the properly protected uracil. The protection of uracil can be introduced into the protective group at its 4-position and 5-position activity check points to ensure that the condensation reaction selectively occurs in the appropriate position. The condensation reaction can be heated with a condensation agent, such as a carbodiimide reagent, in an organic solvent to promote the connection of ribose and uracil to form a nucleoside skeleton.
Then, the nucleoside product is deprotected to remove the protective group on uracil, while retaining 2 '-O-methyl. This step requires fine regulation of the reaction conditions to precisely remove the protective group without affecting the other structures of the nucleoside.
Finally, the 5-position iodization reaction is carried out. A suitable iodizing reagent, such as N-iodosuccinimide (NIS), can be used to react in a suitable catalyst and solvent system. This step requires attention to the reaction process and selectivity to avoid excessive iodization or iodization of other non-target sites. Through careful operation in multiple steps, 5-iodine-2 '-O-methyluridine can be obtained. After each step of the reaction, the product needs to be purified by appropriate separation and purification methods, such as column chromatography, recrystallization, etc., to ensure the smooth progress of the reaction and the purity of the final product.
What is the price range of Uridine, 5-iodo-2 '-o-methyl- (8ci, 9ci) in the market?
I don't know the price range of "Uridine, 5-iodo-2 '-o-methyl- (8ci, 9ci) " in the market. However, if you want to know the price of this product, you can find it from several places.
First, you can go to various chemical trading platforms. Such platforms gather many merchants and list the prices of various chemicals, or you can get this "Uridine, 5-iodo-2' -o-methyl- (8ci, 9ci) " price range.
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Third, check relevant industry reports and research literature. It may contain chemical market price analysis, or there may be clues about the price of this "Uridine, 5-iodo-2 '-o-methyl- (8ci, 9ci) ".
But the market price often changes due to quality, purity, supply and demand, etc. To get an accurate price, you need to study the market carefully and consult more merchants.